Successful Hand Transplantation — One-Year Follow-up
In 1996, the Louisville Hand Transplant Team was formed to examine the possibility of performing a human hand transplantation. One of our first goals was to develop procedures for the transplantation of allografts of extremities in large animals. 1 , 2 In contrast to prior studies of hand transplant...
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| Veröffentlicht in: | The New England journal of medicine 2000-08, Vol.343 (7), p.468-473 |
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| container_end_page | 473 |
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| container_title | The New England journal of medicine |
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| creator | Jones, Jon W Gruber, Scott A Barker, John H Breidenbach, Warren C |
| description | In 1996, the Louisville Hand Transplant Team was formed to examine the possibility of performing a human hand transplantation. One of our first goals was to develop procedures for the transplantation of allografts of extremities in large animals.
1
,
2
In contrast to prior studies of hand transplantation in primates, in which very high doses of cyclosporine and prednisone did not prevent rejection episodes and had many adverse effects,
3
–
5
we found that in pigs that received extremity transplants, rejection could be delayed with a regimen of cyclosporine, mycophenolate mofetil, and prednisone or a regimen of tacrolimus, mycophenolate mofetil, and prednisone. . . . |
| doi_str_mv | 10.1056/NEJM200008173430704 |
| format | Article |
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1
,
2
In contrast to prior studies of hand transplantation in primates, in which very high doses of cyclosporine and prednisone did not prevent rejection episodes and had many adverse effects,
3
–
5
we found that in pigs that received extremity transplants, rejection could be delayed with a regimen of cyclosporine, mycophenolate mofetil, and prednisone or a regimen of tacrolimus, mycophenolate mofetil, and prednisone. . . .</description><identifier>ISSN: 0028-4793</identifier><identifier>EISSN: 1533-4406</identifier><identifier>DOI: 10.1056/NEJM200008173430704</identifier><identifier>CODEN: NEJMAG</identifier><language>eng</language><publisher>Boston, MA: Massachusetts Medical Society</publisher><subject>basiliximab ; Biological and medical sciences ; Medical sciences ; mycophenolate mofetil ; Orthopedic surgery ; prednisone ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; tacrolimus</subject><ispartof>The New England journal of medicine, 2000-08, Vol.343 (7), p.468-473</ispartof><rights>Copyright © 2000 Massachusetts Medical Society. All rights reserved.</rights><rights>2000 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c541t-6dbaa6c35ffc07d41e4078901c4ba892c1bdc77c37ed04118b86aabfc3acfcdd3</citedby><cites>FETCH-LOGICAL-c541t-6dbaa6c35ffc07d41e4078901c4ba892c1bdc77c37ed04118b86aabfc3acfcdd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.nejm.org/doi/pdf/10.1056/NEJM200008173430704$$EPDF$$P50$$Gmms$$H</linktopdf><linktohtml>$$Uhttps://www.nejm.org/doi/full/10.1056/NEJM200008173430704$$EHTML$$P50$$Gmms$$H</linktohtml><link.rule.ids>314,776,780,2746,2747,26080,27901,27902,52357,54039</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1456912$$DView record in Pascal Francis$$Hfree_for_read</backlink></links><search><creatorcontrib>Jones, Jon W</creatorcontrib><creatorcontrib>Gruber, Scott A</creatorcontrib><creatorcontrib>Barker, John H</creatorcontrib><creatorcontrib>Breidenbach, Warren C</creatorcontrib><title>Successful Hand Transplantation — One-Year Follow-up</title><title>The New England journal of medicine</title><description>In 1996, the Louisville Hand Transplant Team was formed to examine the possibility of performing a human hand transplantation. One of our first goals was to develop procedures for the transplantation of allografts of extremities in large animals.
1
,
2
In contrast to prior studies of hand transplantation in primates, in which very high doses of cyclosporine and prednisone did not prevent rejection episodes and had many adverse effects,
3
–
5
we found that in pigs that received extremity transplants, rejection could be delayed with a regimen of cyclosporine, mycophenolate mofetil, and prednisone or a regimen of tacrolimus, mycophenolate mofetil, and prednisone. . . .</description><subject>basiliximab</subject><subject>Biological and medical sciences</subject><subject>Medical sciences</subject><subject>mycophenolate mofetil</subject><subject>Orthopedic surgery</subject><subject>prednisone</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>tacrolimus</subject><issn>0028-4793</issn><issn>1533-4406</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><recordid>eNp9kL9OwzAQhy0EEqXwBCwZEAsK2LFjJyOqWgoqdKAMTNblYkup8g87EWLjIXhCnoRUqcSCuOWW7_fp7kfIOaPXjMby5mn-8BjRYRKmuOBUUXFAJizmPBSCykMyoTRKQqFSfkxOvN_uWCbSCZHPPaLx3vZlsIQ6DzYOat-WUHfQFU0dfH9-BevahK8GXLBoyrJ5D_v2lBxZKL052-8peVnMN7NluFrf3c9uVyHGgnWhzDMAiTy2FqnKBTOCqiSlDEUGSRohy3JUCrkyORWMJVkiATKLHNBinvMpuRy9rWveeuM7XRUeTTncZ5rea6ZiKSKpBpCPILrGe2esbl1RgfvQjOpdR_qPjobUxV4PHqG0w-9Y-N-oiGXKogG7GrGq8ro22-pf6Q8wUHM6</recordid><startdate>20000817</startdate><enddate>20000817</enddate><creator>Jones, Jon W</creator><creator>Gruber, Scott A</creator><creator>Barker, John H</creator><creator>Breidenbach, Warren C</creator><general>Massachusetts Medical Society</general><scope>IQODW</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>20000817</creationdate><title>Successful Hand Transplantation — One-Year Follow-up</title><author>Jones, Jon W ; Gruber, Scott A ; Barker, John H ; Breidenbach, Warren C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c541t-6dbaa6c35ffc07d41e4078901c4ba892c1bdc77c37ed04118b86aabfc3acfcdd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>basiliximab</topic><topic>Biological and medical sciences</topic><topic>Medical sciences</topic><topic>mycophenolate mofetil</topic><topic>Orthopedic surgery</topic><topic>prednisone</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>tacrolimus</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jones, Jon W</creatorcontrib><creatorcontrib>Gruber, Scott A</creatorcontrib><creatorcontrib>Barker, John H</creatorcontrib><creatorcontrib>Breidenbach, Warren C</creatorcontrib><collection>Pascal-Francis</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>The New England journal of medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jones, Jon W</au><au>Gruber, Scott A</au><au>Barker, John H</au><au>Breidenbach, Warren C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Successful Hand Transplantation — One-Year Follow-up</atitle><jtitle>The New England journal of medicine</jtitle><date>2000-08-17</date><risdate>2000</risdate><volume>343</volume><issue>7</issue><spage>468</spage><epage>473</epage><pages>468-473</pages><issn>0028-4793</issn><eissn>1533-4406</eissn><coden>NEJMAG</coden><abstract>In 1996, the Louisville Hand Transplant Team was formed to examine the possibility of performing a human hand transplantation. One of our first goals was to develop procedures for the transplantation of allografts of extremities in large animals.
1
,
2
In contrast to prior studies of hand transplantation in primates, in which very high doses of cyclosporine and prednisone did not prevent rejection episodes and had many adverse effects,
3
–
5
we found that in pigs that received extremity transplants, rejection could be delayed with a regimen of cyclosporine, mycophenolate mofetil, and prednisone or a regimen of tacrolimus, mycophenolate mofetil, and prednisone. . . .</abstract><cop>Boston, MA</cop><pub>Massachusetts Medical Society</pub><doi>10.1056/NEJM200008173430704</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | The New England journal of medicine, 2000-08, Vol.343 (7), p.468-473 |
| issn | 0028-4793 1533-4406 |
| language | eng |
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| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; New England Journal of Medicine |
| subjects | basiliximab Biological and medical sciences Medical sciences mycophenolate mofetil Orthopedic surgery prednisone Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases tacrolimus |
| title | Successful Hand Transplantation — One-Year Follow-up |
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