A combination of benznidazole and ketoconazole enhances efficacy of chemotherapy of experimental Chagas' disease

Despite the large number of patients infected with Trypanosoma cruzi, there are no commercial drugs available with high efficacy for use in the clinical treatment of Chagas' disease (American trypanosomiasis). As the prospects of the introduction of new compounds by the pharmaceutical industry...

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Veröffentlicht in:	Journal of antimicrobial chemotherapy 2000-06, Vol.45 (6), p.819-824
Hauptverfasser:	Araújo, M. S. S., Martins-Filho, O. A., Pereira, M. E. S., Brener, Z.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Infective Agents - therapeutic use Antibiotics. Antiinfectious agents. Antiparasitic agents Antifungal Agents - therapeutic use Antiparasitic agents benznidazole Biological and medical sciences Chagas Disease - blood Chagas Disease - drug therapy Chagas Disease - parasitology Drug Combinations Drug Synergism Female ketoconazole Ketoconazole - therapeutic use Medical sciences Mice Nitroimidazoles - therapeutic use Ofloxacin - therapeutic use Pharmacology. Drug treatments Time Factors Trypanocidal Agents - therapeutic use Trypanosoma cruzi Trypanosoma cruzi - drug effects
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