Three-year outcomes of dietary fatty acid modification and house dust mite reduction in the Childhood Asthma Prevention Study
Two factors thought to influence the risk of asthma are the promoting effect of sensitization to house dust mites and the preventive effect of increased omega-3 fatty acids. Although house dust mite allergen avoidance has been used as a preventive strategy in several trials, the effect of omega-3 fa...
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| Veröffentlicht in: | Journal of allergy and clinical immunology 2004-10, Vol.114 (4), p.807-813 |
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| container_title | Journal of allergy and clinical immunology |
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| creator | Peat, Jennifer K. Mihrshahi, Seema Kemp, Andrew S. Marks, Guy B. Tovey, Euan R. Webb, Karen Mellis, Craig M. Leeder, Stephen R. |
| description | Two factors thought to influence the risk of asthma are the promoting effect of sensitization to house dust mites and the preventive effect of increased omega-3 fatty acids. Although house dust mite allergen avoidance has been used as a preventive strategy in several trials, the effect of omega-3 fatty acid supplementation in the primary prevention of asthma and allergic disease is not known.
To measure the effects of dietary supplementation with omega-3 fatty acids and house dust mite allergen avoidance in children with a family history of asthma.
A total of 616 children at high risk of asthma were enrolled antenatally in a randomized controlled trial, and 526 children remained in the trial at age 3 years. The outcomes were symptoms of allergic disease and allergen sensitization.
There was a significant 10.0% (95% CI, 3.7-16.4) reduction in the prevalence of cough in atopic children in the active diet group (
P
=
.003; number needed to treat, 10) but a negligible 1.1% (95% CI, −7.1 to 9.5) reduction cough among nonatopic children. There was a 7.2% (95% CI, 10.11-14.3) reduction in sensitization to house dust mite in the active allergen avoidance group (
P
=
.05; number needed to treat, 14). No significant differences in wheeze were found with either intervention.
These results suggest that our interventions, designed to be used in simple public health campaigns, may have a role in preventing the development of allergic sensitization and airways disease in early childhood. This offers the prospect of reducing allergic disease in later life. |
| doi_str_mv | 10.1016/j.jaci.2004.06.057 |
| format | Article |
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To measure the effects of dietary supplementation with omega-3 fatty acids and house dust mite allergen avoidance in children with a family history of asthma.
A total of 616 children at high risk of asthma were enrolled antenatally in a randomized controlled trial, and 526 children remained in the trial at age 3 years. The outcomes were symptoms of allergic disease and allergen sensitization.
There was a significant 10.0% (95% CI, 3.7-16.4) reduction in the prevalence of cough in atopic children in the active diet group (
P
=
.003; number needed to treat, 10) but a negligible 1.1% (95% CI, −7.1 to 9.5) reduction cough among nonatopic children. There was a 7.2% (95% CI, 10.11-14.3) reduction in sensitization to house dust mite in the active allergen avoidance group (
P
=
.05; number needed to treat, 14). No significant differences in wheeze were found with either intervention.
These results suggest that our interventions, designed to be used in simple public health campaigns, may have a role in preventing the development of allergic sensitization and airways disease in early childhood. This offers the prospect of reducing allergic disease in later life.</description><identifier>ISSN: 0091-6749</identifier><identifier>EISSN: 1097-6825</identifier><identifier>DOI: 10.1016/j.jaci.2004.06.057</identifier><identifier>PMID: 15480319</identifier><identifier>CODEN: JACIBY</identifier><language>eng</language><publisher>New York, NY: Mosby, Inc</publisher><subject>Adult ; Air Pollution, Indoor - prevention & control ; Allergen avoidance ; Allergens - immunology ; Allergies ; allergy ; Asthma ; Asthma - diet therapy ; Asthma - prevention & control ; atopy ; Bedding and Linens ; Biological and medical sciences ; Child, Preschool ; Children & youth ; Cohort Studies ; Dietary Fats - therapeutic use ; Dietary Supplements ; Eczema ; Fatty acids ; Fatty Acids, Omega-3 - therapeutic use ; Female ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; house dust mite ; Humans ; Immunopathology ; Infant ; Infant, Newborn ; Male ; Medical sciences ; omega-3 fatty acids ; Pregnancy ; primary prevention ; Pyroglyphidae - immunology ; Treatment Outcome</subject><ispartof>Journal of allergy and clinical immunology, 2004-10, Vol.114 (4), p.807-813</ispartof><rights>2004 American Academy of Allergy, Asthma and Immunology</rights><rights>2004 INIST-CNRS</rights><rights>Copyright Elsevier Limited Oct 2004</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c507t-d3fc791c8b1d91979c9762b8a3d17463bfa7fbd270ea523c16a12b0087e180403</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0091674904020135$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16198805$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15480319$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Peat, Jennifer K.</creatorcontrib><creatorcontrib>Mihrshahi, Seema</creatorcontrib><creatorcontrib>Kemp, Andrew S.</creatorcontrib><creatorcontrib>Marks, Guy B.</creatorcontrib><creatorcontrib>Tovey, Euan R.</creatorcontrib><creatorcontrib>Webb, Karen</creatorcontrib><creatorcontrib>Mellis, Craig M.</creatorcontrib><creatorcontrib>Leeder, Stephen R.</creatorcontrib><creatorcontrib>for the Childhood Asthma Prevention Study Team</creatorcontrib><title>Three-year outcomes of dietary fatty acid modification and house dust mite reduction in the Childhood Asthma Prevention Study</title><title>Journal of allergy and clinical immunology</title><addtitle>J Allergy Clin Immunol</addtitle><description>Two factors thought to influence the risk of asthma are the promoting effect of sensitization to house dust mites and the preventive effect of increased omega-3 fatty acids. Although house dust mite allergen avoidance has been used as a preventive strategy in several trials, the effect of omega-3 fatty acid supplementation in the primary prevention of asthma and allergic disease is not known.
To measure the effects of dietary supplementation with omega-3 fatty acids and house dust mite allergen avoidance in children with a family history of asthma.
A total of 616 children at high risk of asthma were enrolled antenatally in a randomized controlled trial, and 526 children remained in the trial at age 3 years. The outcomes were symptoms of allergic disease and allergen sensitization.
There was a significant 10.0% (95% CI, 3.7-16.4) reduction in the prevalence of cough in atopic children in the active diet group (
P
=
.003; number needed to treat, 10) but a negligible 1.1% (95% CI, −7.1 to 9.5) reduction cough among nonatopic children. There was a 7.2% (95% CI, 10.11-14.3) reduction in sensitization to house dust mite in the active allergen avoidance group (
P
=
.05; number needed to treat, 14). No significant differences in wheeze were found with either intervention.
These results suggest that our interventions, designed to be used in simple public health campaigns, may have a role in preventing the development of allergic sensitization and airways disease in early childhood. This offers the prospect of reducing allergic disease in later life.</description><subject>Adult</subject><subject>Air Pollution, Indoor - prevention & control</subject><subject>Allergen avoidance</subject><subject>Allergens - immunology</subject><subject>Allergies</subject><subject>allergy</subject><subject>Asthma</subject><subject>Asthma - diet therapy</subject><subject>Asthma - prevention & control</subject><subject>atopy</subject><subject>Bedding and Linens</subject><subject>Biological and medical sciences</subject><subject>Child, Preschool</subject><subject>Children & youth</subject><subject>Cohort Studies</subject><subject>Dietary Fats - therapeutic use</subject><subject>Dietary Supplements</subject><subject>Eczema</subject><subject>Fatty acids</subject><subject>Fatty Acids, Omega-3 - therapeutic use</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>house dust mite</subject><subject>Humans</subject><subject>Immunopathology</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Male</subject><subject>Medical sciences</subject><subject>omega-3 fatty acids</subject><subject>Pregnancy</subject><subject>primary prevention</subject><subject>Pyroglyphidae - immunology</subject><subject>Treatment Outcome</subject><issn>0091-6749</issn><issn>1097-6825</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kUtr3DAURk1paSZp_0AXRVCand0rP_SAbsLQFwRaaLoWsnSNZWwrleTALPrfq8kMBLroSgid-9B3iuINhYoCZR-matLGVTVAWwGroOPPih0FyUsm6u55sQOQtGS8lRfFZYwT5Hsj5MvignatgIbKXfHnbgyI5QF1IH5Lxi8YiR-IdZh0OJBBp3QgeYwli7ducEYn51eiV0tGv0UkdouJLC4hCWg38_jqVpJGJPvRzXb03pKbmMZFkx8BH3B9RH6mzR5eFS8GPUd8fT6vil-fP93tv5a3379829_clqYDnkrbDIZLakRPraSSSyM5q3uhG0t5y5p-0Hzobc0BdVc3hjJN6x5AcKQCWmiuiutT3_vgf28Yk1pcNDjPesX8CUV51wnR8gy--wec_BbWvJuiHbQix8e6TNUnygQfY8BB3Qe35LgUBXVUoyZ1VKOOahQwldXkorfn1lu_oH0qObvIwPszoKPR8xD0alx84hiVQsBx-scThzmxB4dBReNwNWhdQJOU9e5_e_wFHKKtJw</recordid><startdate>20041001</startdate><enddate>20041001</enddate><creator>Peat, Jennifer K.</creator><creator>Mihrshahi, Seema</creator><creator>Kemp, Andrew S.</creator><creator>Marks, Guy B.</creator><creator>Tovey, Euan R.</creator><creator>Webb, Karen</creator><creator>Mellis, Craig M.</creator><creator>Leeder, Stephen R.</creator><general>Mosby, Inc</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SS</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope></search><sort><creationdate>20041001</creationdate><title>Three-year outcomes of dietary fatty acid modification and house dust mite reduction in the Childhood Asthma Prevention Study</title><author>Peat, Jennifer K. ; Mihrshahi, Seema ; Kemp, Andrew S. ; Marks, Guy B. ; Tovey, Euan R. ; Webb, Karen ; Mellis, Craig M. ; Leeder, Stephen R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c507t-d3fc791c8b1d91979c9762b8a3d17463bfa7fbd270ea523c16a12b0087e180403</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adult</topic><topic>Air Pollution, Indoor - prevention & control</topic><topic>Allergen avoidance</topic><topic>Allergens - immunology</topic><topic>Allergies</topic><topic>allergy</topic><topic>Asthma</topic><topic>Asthma - diet therapy</topic><topic>Asthma - prevention & control</topic><topic>atopy</topic><topic>Bedding and Linens</topic><topic>Biological and medical sciences</topic><topic>Child, Preschool</topic><topic>Children & youth</topic><topic>Cohort Studies</topic><topic>Dietary Fats - therapeutic use</topic><topic>Dietary Supplements</topic><topic>Eczema</topic><topic>Fatty acids</topic><topic>Fatty Acids, Omega-3 - therapeutic use</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>house dust mite</topic><topic>Humans</topic><topic>Immunopathology</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Male</topic><topic>Medical sciences</topic><topic>omega-3 fatty acids</topic><topic>Pregnancy</topic><topic>primary prevention</topic><topic>Pyroglyphidae - immunology</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Peat, Jennifer K.</creatorcontrib><creatorcontrib>Mihrshahi, Seema</creatorcontrib><creatorcontrib>Kemp, Andrew S.</creatorcontrib><creatorcontrib>Marks, Guy B.</creatorcontrib><creatorcontrib>Tovey, Euan R.</creatorcontrib><creatorcontrib>Webb, Karen</creatorcontrib><creatorcontrib>Mellis, Craig M.</creatorcontrib><creatorcontrib>Leeder, Stephen R.</creatorcontrib><creatorcontrib>for the Childhood Asthma Prevention Study Team</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><jtitle>Journal of allergy and clinical immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Peat, Jennifer K.</au><au>Mihrshahi, Seema</au><au>Kemp, Andrew S.</au><au>Marks, Guy B.</au><au>Tovey, Euan R.</au><au>Webb, Karen</au><au>Mellis, Craig M.</au><au>Leeder, Stephen R.</au><aucorp>for the Childhood Asthma Prevention Study Team</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Three-year outcomes of dietary fatty acid modification and house dust mite reduction in the Childhood Asthma Prevention Study</atitle><jtitle>Journal of allergy and clinical immunology</jtitle><addtitle>J Allergy Clin Immunol</addtitle><date>2004-10-01</date><risdate>2004</risdate><volume>114</volume><issue>4</issue><spage>807</spage><epage>813</epage><pages>807-813</pages><issn>0091-6749</issn><eissn>1097-6825</eissn><coden>JACIBY</coden><abstract>Two factors thought to influence the risk of asthma are the promoting effect of sensitization to house dust mites and the preventive effect of increased omega-3 fatty acids. Although house dust mite allergen avoidance has been used as a preventive strategy in several trials, the effect of omega-3 fatty acid supplementation in the primary prevention of asthma and allergic disease is not known.
To measure the effects of dietary supplementation with omega-3 fatty acids and house dust mite allergen avoidance in children with a family history of asthma.
A total of 616 children at high risk of asthma were enrolled antenatally in a randomized controlled trial, and 526 children remained in the trial at age 3 years. The outcomes were symptoms of allergic disease and allergen sensitization.
There was a significant 10.0% (95% CI, 3.7-16.4) reduction in the prevalence of cough in atopic children in the active diet group (
P
=
.003; number needed to treat, 10) but a negligible 1.1% (95% CI, −7.1 to 9.5) reduction cough among nonatopic children. There was a 7.2% (95% CI, 10.11-14.3) reduction in sensitization to house dust mite in the active allergen avoidance group (
P
=
.05; number needed to treat, 14). No significant differences in wheeze were found with either intervention.
These results suggest that our interventions, designed to be used in simple public health campaigns, may have a role in preventing the development of allergic sensitization and airways disease in early childhood. This offers the prospect of reducing allergic disease in later life.</abstract><cop>New York, NY</cop><pub>Mosby, Inc</pub><pmid>15480319</pmid><doi>10.1016/j.jaci.2004.06.057</doi><tpages>7</tpages></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adult Air Pollution, Indoor - prevention & control Allergen avoidance Allergens - immunology Allergies allergy Asthma Asthma - diet therapy Asthma - prevention & control atopy Bedding and Linens Biological and medical sciences Child, Preschool Children & youth Cohort Studies Dietary Fats - therapeutic use Dietary Supplements Eczema Fatty acids Fatty Acids, Omega-3 - therapeutic use Female Fundamental and applied biological sciences. Psychology Fundamental immunology house dust mite Humans Immunopathology Infant Infant, Newborn Male Medical sciences omega-3 fatty acids Pregnancy primary prevention Pyroglyphidae - immunology Treatment Outcome |
| title | Three-year outcomes of dietary fatty acid modification and house dust mite reduction in the Childhood Asthma Prevention Study |
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