Roles of JNK, p38 and ERK mitogen-activated protein kinases in the growth inhibition and apoptosis induced by cadmium

Cadmium (Cd), a human carcinogen, can induce apoptosis in various cell types. Three major mitogen-activated protein kinases (MAPKs), c-JUN N-terminal kinase (JNK), p38 and extracellular signal-regulated kinase (ERK), have been shown to regulate apoptosis. In this study we explore the ability of Cd t...

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Veröffentlicht in:	Carcinogenesis (New York) 2000-07, Vol.21 (7), p.1423-1432
Hauptverfasser:	CHUANG, S.-M, WANG, I.-C, YANG, J.-L
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - enzymology Adenocarcinoma - pathology Apoptosis - drug effects Apoptosis - physiology Biological and medical sciences Cadmium - toxicity Cell Division - drug effects Cell Division - physiology Cell Survival - drug effects DNA, Neoplasm - metabolism Enzyme Activation - drug effects Enzyme Activators ERK protein Gene Expression Regulation, Neoplastic - drug effects Genes, jun Growth Inhibitors - toxicity Humans JNK Mitogen-Activated Protein Kinases JNK protein lung carcinoma Lung Neoplasms - enzymology Lung Neoplasms - pathology Male MAP Kinase Kinase 4 MAP Kinase Kinase 7 Medical sciences Middle Aged Mitogen-Activated Protein Kinase Kinases - genetics Mitogen-Activated Protein Kinase Kinases - metabolism Mitogen-Activated Protein Kinase Kinases - physiology Mitogen-Activated Protein Kinases - metabolism Mitogen-Activated Protein Kinases - physiology p38 Mitogen-Activated Protein Kinases p38 protein Pneumology Proto-Oncogene Proteins c-jun - biosynthesis Proto-Oncogene Proteins c-jun - genetics Transcription Factor AP-1 - metabolism Transfection Tumor Cells, Cultured Tumors of the respiratory system and mediastinum
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