Dithiocarbamates Inhibit Hematopoiesis via a Copper-Dependent Mechanism

Dithiocarbamates (DTC), an important class of therapeutic and industrial chemicals, have alternatively been reported to be either beneficial or toxic to the hematopoietic and immune systems. In the present study, we investigated the potential of dimethyl- and diethyl-dithiocarbamate to alter clonoge...

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Veröffentlicht in:	Biochemical and biophysical research communications 2000-08, Vol.274 (2), p.513-518
Hauptverfasser:	Pyatt, David W., Yang, Yanzhu, Le, Anh, Stillman, Wayne S., Irons, Richard D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens, CD34 - metabolism Apoptosis bone marrow bone marrow cells Bone Marrow Cells - cytology Bone Marrow Cells - drug effects Bone Marrow Cells - metabolism CD34 antigen Cell Separation Cells, Cultured Chelating Agents - pharmacology Colony-Forming Units Assay Copper - metabolism Copper - pharmacology Dimethyldithiocarbamate - pharmacology dithiocarbamate dithiocarbamates Ditiocarb - pharmacology Dose-Response Relationship, Drug Drug Synergism Hematopoiesis - drug effects Humans In Situ Nick-End Labeling NF-^KB protein NF-B protein NF-kappa B - metabolism
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