SV40-dependent AKT activity drives mesothelial cell transformation after asbestos exposure

Human malignant mesothelioma is an aggressive cancer generally associated with exposure to asbestos, although SV40 virus has been involved as a possible cofactor by a number of studies. Asbestos fibers induce cytotoxicity in human mesothelial cells (HMC), although cell survival activated by key sign...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2005-06, Vol.65 (12), p.5256-5262
Hauptverfasser:	CACCIOTTI, Paola, BARBONE, Dario, PORTA, Camillo, ALTOMARE, Deborah A, TESTA, Joseph R, MUTTI, Luciano, GAUDINO, Giovanni
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Apoptosis - physiology Asbestos - toxicity Biological and medical sciences Cell Transformation, Viral Cocarcinogenesis Epithelial Cells - cytology Epithelial Cells - drug effects Epithelial Cells - enzymology Epithelial Cells - virology Humans Medical sciences Mesothelioma - enzymology Mesothelioma - etiology Mesothelioma - pathology Mesothelioma - virology Pharmacology. Drug treatments Phosphatidylinositol 3-Kinases - metabolism Phosphorylation Protein-Serine-Threonine Kinases - metabolism Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins c-akt Simian virus 40 Simian virus 40 - physiology Tumors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!