Gas phase oxidants of cigarette smoke increase nitric oxide synthase and xanthine oxidase activities of rabbit brain synaptosomes

In the present study we demonstrated that NO synthase and xanthine oxidase of synaptosomes isolated from rabbit brain cortex can be activated by the gas phase of cigarette smoke to produce nitric oxide and superoxide which react together to form peroxynitrite. Expose of synaptosomes, up to 3 hours,...

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Veröffentlicht in:	Neurochemical research 2000-06, Vol.25 (6), p.769-774
Hauptverfasser:	DELICONSTANTINOS, G, VILLIOTOU, V
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Brain - drug effects Brain - enzymology Medical sciences Membrane Fluidity Nicotiana Nitric Oxide Synthase - metabolism Oxidants - pharmacology oxypurinol Plants, Toxic Rabbits Smoke Synaptosomes - drug effects Synaptosomes - enzymology Tobacco, tobacco smoking Toxicology Xanthine Oxidase - metabolism
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