Tribromomethane exposure and dietary folate deficiency in the formation of aberrant crypt foci in the colons of F344/N rats

Folate and folic acid are forms of the B vitamin that are involved in the synthesis, repair, and functioning of DNA and are required for the production and maintenance of cells. Low levels of folate have been associated with several forms of cancer, including colon cancer. Aberrant crypt foci (ACF),...

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Veröffentlicht in:	Food and chemical toxicology 2005-09, Vol.43 (9), p.1405-1412
Hauptverfasser:	Geter, David R., Moore, Tanya M., George, Michael H., Kilburn, Steve R., Allen, James W., Nelson, Gail M., Winkfield, Ernest, DeAngelo, Anthony B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aberrant crypt foci Animals Biological and medical sciences Body Weight - drug effects Bromoform byproducts carcinogenesis carcinogens chloroform Colon cancer Colonic Neoplasms - chemically induced Colonic Neoplasms - etiology Colonic Neoplasms - pathology colorectal neoplasms Diet disinfectants Disinfectants - toxicity DNA damage Dose-Response Relationship, Drug Drinking water Eating - drug effects Folate folic acid Folic Acid - blood Folic Acid Deficiency - pathology genotoxicity Homocysteine - blood Male Medical sciences Rats Rats, Inbred F344 risk factors Toxicology Trihalomethane Trihalomethanes - toxicity vitamin deficiencies Water Supply
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