Calretinin-containing axons and neurons are resistant to an intrastriatal 6-hydroxydopamine lesion
Relative preservation of dopaminergic axons in patches and a subcallosal layer was observed in the dorsal, lateral and caudal striatum 4 weeks after intrastriatal injection of 6-hydroxydopamine (6-OHDA), a neurotoxin selective for catecholaminergic neurons. Since calcium binding proteins are reporte...
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| Veröffentlicht in: | Brain research 2000-06, Vol.866 (1), p.55-64 |
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| creator | Tsuboi, Kyoko Kimber, Teresa A Shults, Clifford W |
| description | Relative preservation of dopaminergic axons in patches and a subcallosal layer was observed in the dorsal, lateral and caudal striatum 4 weeks after intrastriatal injection of 6-hydroxydopamine (6-OHDA), a neurotoxin selective for catecholaminergic neurons. Since calcium binding proteins are reported to provide neuroprotective influence in neurons, differences in the distribution of the calcium binding proteins might be related to the different vulnerabilities of dopaminergic neurons and axons to neurotoxins. To address this possibility, we characterized patches of relatively dense tyrosine hydroxylase-immunoreactive (TH-IR) axons in intrastriatal 6-OHDA lesioned rats, focusing on two calcium binding proteins, calbindin (CB) and calretinin (CR). The patches and subcallosal layer of preserved dopaminergic axons in the striatum of rats lesioned with 6-OHDA contained CR, a 31-kDa calcium-binding protein, but interestingly not CB. Dopaminergic neurons containing CR in the substantia nigra pars compacta (SNpc) were relatively spared compared to those that did not contain CR. Taken together, our data indicate that dopaminergic axons and neurons containing CR in the nigrostriatal pathway are more resistant to 6-OHDA lesion than those that do not contain CR. |
| doi_str_mv | 10.1016/S0006-8993(00)02219-8 |
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Since calcium binding proteins are reported to provide neuroprotective influence in neurons, differences in the distribution of the calcium binding proteins might be related to the different vulnerabilities of dopaminergic neurons and axons to neurotoxins. To address this possibility, we characterized patches of relatively dense tyrosine hydroxylase-immunoreactive (TH-IR) axons in intrastriatal 6-OHDA lesioned rats, focusing on two calcium binding proteins, calbindin (CB) and calretinin (CR). The patches and subcallosal layer of preserved dopaminergic axons in the striatum of rats lesioned with 6-OHDA contained CR, a 31-kDa calcium-binding protein, but interestingly not CB. Dopaminergic neurons containing CR in the substantia nigra pars compacta (SNpc) were relatively spared compared to those that did not contain CR. Taken together, our data indicate that dopaminergic axons and neurons containing CR in the nigrostriatal pathway are more resistant to 6-OHDA lesion than those that do not contain CR.</description><identifier>ISSN: 0006-8993</identifier><identifier>EISSN: 1872-6240</identifier><identifier>DOI: 10.1016/S0006-8993(00)02219-8</identifier><identifier>PMID: 10825480</identifier><identifier>CODEN: BRREAP</identifier><language>eng</language><publisher>London: Elsevier B.V</publisher><subject>6-Hydroxydopamine ; Animals ; Axons - drug effects ; Axons - metabolism ; Axons - pathology ; Biological and medical sciences ; Calbindin 2 ; Calbindins ; Calretinin ; Dopamine - metabolism ; Drug Resistance - physiology ; Female ; Medical sciences ; Neostriatum - drug effects ; Neostriatum - metabolism ; Neostriatum - pathology ; Nerve Degeneration - chemically induced ; Nerve Degeneration - pathology ; Nerve Degeneration - physiopathology ; Neuropharmacology ; Neuroprotective agent ; Neuroprotective Agents - metabolism ; Neurotoxins - toxicity ; Oxidopamine ; Parkinson Disease - pathology ; Parkinson Disease - physiopathology ; Pharmacology. Drug treatments ; Rats ; Rats, Sprague-Dawley ; S100 Calcium Binding Protein G - metabolism ; Striatum ; Substantia Nigra - drug effects ; Substantia Nigra - metabolism ; Substantia Nigra - pathology ; Substantia nigra pars compacta ; Tyrosine 3-Monooxygenase - metabolism ; Tyrosine hydroxylase</subject><ispartof>Brain research, 2000-06, Vol.866 (1), p.55-64</ispartof><rights>2000 Elsevier Science B.V.</rights><rights>2000 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c473t-2b7cfb287a81dcd15682a35118de4b73af79ef14f16975c86ed0b9d614afcc413</citedby><cites>FETCH-LOGICAL-c473t-2b7cfb287a81dcd15682a35118de4b73af79ef14f16975c86ed0b9d614afcc413</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0006899300022198$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1411054$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10825480$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tsuboi, Kyoko</creatorcontrib><creatorcontrib>Kimber, Teresa A</creatorcontrib><creatorcontrib>Shults, Clifford W</creatorcontrib><title>Calretinin-containing axons and neurons are resistant to an intrastriatal 6-hydroxydopamine lesion</title><title>Brain research</title><addtitle>Brain Res</addtitle><description>Relative preservation of dopaminergic axons in patches and a subcallosal layer was observed in the dorsal, lateral and caudal striatum 4 weeks after intrastriatal injection of 6-hydroxydopamine (6-OHDA), a neurotoxin selective for catecholaminergic neurons. Since calcium binding proteins are reported to provide neuroprotective influence in neurons, differences in the distribution of the calcium binding proteins might be related to the different vulnerabilities of dopaminergic neurons and axons to neurotoxins. To address this possibility, we characterized patches of relatively dense tyrosine hydroxylase-immunoreactive (TH-IR) axons in intrastriatal 6-OHDA lesioned rats, focusing on two calcium binding proteins, calbindin (CB) and calretinin (CR). The patches and subcallosal layer of preserved dopaminergic axons in the striatum of rats lesioned with 6-OHDA contained CR, a 31-kDa calcium-binding protein, but interestingly not CB. Dopaminergic neurons containing CR in the substantia nigra pars compacta (SNpc) were relatively spared compared to those that did not contain CR. Taken together, our data indicate that dopaminergic axons and neurons containing CR in the nigrostriatal pathway are more resistant to 6-OHDA lesion than those that do not contain CR.</description><subject>6-Hydroxydopamine</subject><subject>Animals</subject><subject>Axons - drug effects</subject><subject>Axons - metabolism</subject><subject>Axons - pathology</subject><subject>Biological and medical sciences</subject><subject>Calbindin 2</subject><subject>Calbindins</subject><subject>Calretinin</subject><subject>Dopamine - metabolism</subject><subject>Drug Resistance - physiology</subject><subject>Female</subject><subject>Medical sciences</subject><subject>Neostriatum - drug effects</subject><subject>Neostriatum - metabolism</subject><subject>Neostriatum - pathology</subject><subject>Nerve Degeneration - chemically induced</subject><subject>Nerve Degeneration - pathology</subject><subject>Nerve Degeneration - physiopathology</subject><subject>Neuropharmacology</subject><subject>Neuroprotective agent</subject><subject>Neuroprotective Agents - metabolism</subject><subject>Neurotoxins - toxicity</subject><subject>Oxidopamine</subject><subject>Parkinson Disease - pathology</subject><subject>Parkinson Disease - physiopathology</subject><subject>Pharmacology. Drug treatments</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>S100 Calcium Binding Protein G - metabolism</subject><subject>Striatum</subject><subject>Substantia Nigra - drug effects</subject><subject>Substantia Nigra - metabolism</subject><subject>Substantia Nigra - pathology</subject><subject>Substantia nigra pars compacta</subject><subject>Tyrosine 3-Monooxygenase - metabolism</subject><subject>Tyrosine hydroxylase</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtv1DAQgC3Uii6FnwDKoaroIeBxnNg5IbSCUqlSD8DZmtgTcJW1F9uLuv--2YcKt55mRvPNQx9jb4F_AA7dx--c867Wfd-85_yKCwF9rV-wBWgl6k5IfsIWT8gZe5Xz_Vw2Tc9fsjPgWrRS8wUbljglKj74UNsYCu6yXxU-xJArDK4KtEn7PFGVKPtcMJSqxLlZ-VAS5pI8Fpyqrv69dSk-bF1c48oHqqaZj-E1Ox1xyvTmGM_Zz69ffiy_1bd31zfLz7e1laoptRiUHQehFWpw1kHbaYFNC6AdyUE1OKqeRpAjdL1qre7I8aF3HUgcrZXQnLPLw951in82lItZ-WxpmjBQ3GQDqm2FEGoG2wNoU8w50WjWya8wbQ1ws5Nr9nLNzpzh3OzlGj3PvTse2Awrcv9NHWzOwMURwGxxGhMG6_M_TgLwVs7YpwNGs42_npLJ1lOw5HwiW4yL_plPHgHPLpfj</recordid><startdate>20000602</startdate><enddate>20000602</enddate><creator>Tsuboi, Kyoko</creator><creator>Kimber, Teresa A</creator><creator>Shults, Clifford W</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TK</scope></search><sort><creationdate>20000602</creationdate><title>Calretinin-containing axons and neurons are resistant to an intrastriatal 6-hydroxydopamine lesion</title><author>Tsuboi, Kyoko ; Kimber, Teresa A ; Shults, Clifford W</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c473t-2b7cfb287a81dcd15682a35118de4b73af79ef14f16975c86ed0b9d614afcc413</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>6-Hydroxydopamine</topic><topic>Animals</topic><topic>Axons - drug effects</topic><topic>Axons - metabolism</topic><topic>Axons - pathology</topic><topic>Biological and medical sciences</topic><topic>Calbindin 2</topic><topic>Calbindins</topic><topic>Calretinin</topic><topic>Dopamine - metabolism</topic><topic>Drug Resistance - physiology</topic><topic>Female</topic><topic>Medical sciences</topic><topic>Neostriatum - drug effects</topic><topic>Neostriatum - metabolism</topic><topic>Neostriatum - pathology</topic><topic>Nerve Degeneration - chemically induced</topic><topic>Nerve Degeneration - pathology</topic><topic>Nerve Degeneration - physiopathology</topic><topic>Neuropharmacology</topic><topic>Neuroprotective agent</topic><topic>Neuroprotective Agents - metabolism</topic><topic>Neurotoxins - toxicity</topic><topic>Oxidopamine</topic><topic>Parkinson Disease - pathology</topic><topic>Parkinson Disease - physiopathology</topic><topic>Pharmacology. Drug treatments</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>S100 Calcium Binding Protein G - metabolism</topic><topic>Striatum</topic><topic>Substantia Nigra - drug effects</topic><topic>Substantia Nigra - metabolism</topic><topic>Substantia Nigra - pathology</topic><topic>Substantia nigra pars compacta</topic><topic>Tyrosine 3-Monooxygenase - metabolism</topic><topic>Tyrosine hydroxylase</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tsuboi, Kyoko</creatorcontrib><creatorcontrib>Kimber, Teresa A</creatorcontrib><creatorcontrib>Shults, Clifford W</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tsuboi, Kyoko</au><au>Kimber, Teresa A</au><au>Shults, Clifford W</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Calretinin-containing axons and neurons are resistant to an intrastriatal 6-hydroxydopamine lesion</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>2000-06-02</date><risdate>2000</risdate><volume>866</volume><issue>1</issue><spage>55</spage><epage>64</epage><pages>55-64</pages><issn>0006-8993</issn><eissn>1872-6240</eissn><coden>BRREAP</coden><abstract>Relative preservation of dopaminergic axons in patches and a subcallosal layer was observed in the dorsal, lateral and caudal striatum 4 weeks after intrastriatal injection of 6-hydroxydopamine (6-OHDA), a neurotoxin selective for catecholaminergic neurons. Since calcium binding proteins are reported to provide neuroprotective influence in neurons, differences in the distribution of the calcium binding proteins might be related to the different vulnerabilities of dopaminergic neurons and axons to neurotoxins. To address this possibility, we characterized patches of relatively dense tyrosine hydroxylase-immunoreactive (TH-IR) axons in intrastriatal 6-OHDA lesioned rats, focusing on two calcium binding proteins, calbindin (CB) and calretinin (CR). The patches and subcallosal layer of preserved dopaminergic axons in the striatum of rats lesioned with 6-OHDA contained CR, a 31-kDa calcium-binding protein, but interestingly not CB. Dopaminergic neurons containing CR in the substantia nigra pars compacta (SNpc) were relatively spared compared to those that did not contain CR. Taken together, our data indicate that dopaminergic axons and neurons containing CR in the nigrostriatal pathway are more resistant to 6-OHDA lesion than those that do not contain CR.</abstract><cop>London</cop><cop>Amsterdam</cop><cop>New York, NY</cop><pub>Elsevier B.V</pub><pmid>10825480</pmid><doi>10.1016/S0006-8993(00)02219-8</doi><tpages>10</tpages></addata></record> |
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| subjects | 6-Hydroxydopamine Animals Axons - drug effects Axons - metabolism Axons - pathology Biological and medical sciences Calbindin 2 Calbindins Calretinin Dopamine - metabolism Drug Resistance - physiology Female Medical sciences Neostriatum - drug effects Neostriatum - metabolism Neostriatum - pathology Nerve Degeneration - chemically induced Nerve Degeneration - pathology Nerve Degeneration - physiopathology Neuropharmacology Neuroprotective agent Neuroprotective Agents - metabolism Neurotoxins - toxicity Oxidopamine Parkinson Disease - pathology Parkinson Disease - physiopathology Pharmacology. Drug treatments Rats Rats, Sprague-Dawley S100 Calcium Binding Protein G - metabolism Striatum Substantia Nigra - drug effects Substantia Nigra - metabolism Substantia Nigra - pathology Substantia nigra pars compacta Tyrosine 3-Monooxygenase - metabolism Tyrosine hydroxylase |
| title | Calretinin-containing axons and neurons are resistant to an intrastriatal 6-hydroxydopamine lesion |
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