Effects of lonidamine on testicular and epididymal proteins in the rat

The mechanism responsible for the antispermatogenic activity of lonidamine (LND) [1-(2,4-dichlorobenzyl)-1H-indazole-3-carboxylic acid], a drug with low systemic toxicity and lack of significant hormonal effects, is still unclear but may be related to alterations of Sertoli cell proteins. Here, we c...

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Veröffentlicht in:	Reproductive toxicology (Elmsford, N.Y.) N.Y.), 2000-05, Vol.14 (3), p.257-263
Hauptverfasser:	Leone, Maria Grazia, Grippa, Eleonora, Guidolin, Diego, Tita, Beatrice, Abdel–Haq, Hanin, Gatto, Maria Teresa, Bordi, Federica, Cheng, C.Yan, Silvestrini, Bruno, Saso, Luciano
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute-Phase Proteins - metabolism alpha-Macroglobulins - metabolism Animals Antispermatogenic Agents - toxicity Antispermatogenic drugs Biological and medical sciences Concanavalin A Electrophoresis, Polyacrylamide Gel Genital system. Reproduction Indazoles - toxicity Lonidamine macroglobulins Macroglobulins - metabolism Male Medical sciences Orchitis - chemically induced Orchitis - metabolism Orchitis - pathology Organ Size - drug effects Pharmacology. Drug treatments Rats Rats, Sprague-Dawley SDS-PAGE Spermatogenesis - drug effects Testicular and epididymal proteins Testis - drug effects Testis - metabolism Testis - pathology α 1-Inhibitor-3 α 1-Macroglobulin α 2-Macroglobulin
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