Heterogeneous Nuclear Ribonucleoprotein F/H Proteins Modulate the Alternative Splicing of the Apoptotic Mediator Bcl-x

Bcl-x is a member of the Bcl-2 family of proteins that are key regulators of apoptosis. The Bcl-x pre-mRNA is alternatively spliced to yield Bcl-x S and Bcl-x L , two isoforms that have been associated, respectively, with the promotion and the prevention of apoptosis. We have investigated some of th...

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Veröffentlicht in:	The Journal of biological chemistry 2005-06, Vol.280 (24), p.22641-22650
Hauptverfasser:	Garneau, Daniel, Revil, Timothée, Fisette, Jean-François, Chabot, Benoit
Format:	Artikel
Sprache:	eng
Schlagworte:	Alternative Splicing Apoptosis bcl-X Protein Blotting, Western DNA, Complementary - metabolism Exons Gene Deletion HeLa Cells Heterogeneous-Nuclear Ribonucleoprotein Group F-H - chemistry Humans Mutagenesis, Site-Directed Plasmids - metabolism Protein Binding Protein Structure, Tertiary Proto-Oncogene Proteins c-bcl-2 - chemistry Proto-Oncogene Proteins c-bcl-2 - genetics Recombinant Proteins - chemistry Reverse Transcriptase Polymerase Chain Reaction RNA Interference RNA, Messenger - metabolism RNA, Small Interfering - metabolism Transcription, Genetic Transfection
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