A role for the p38 mitogen-activated protein kinase pathway in the transcriptional activation of p53 on genotoxic stress by chemotherapeutic agents

The tumor suppressor p53 plays a central role in sensing damaged DNA and orchestrating the consequent cellular responses. However, how DNA damage leads to the activation of p53 is still poorly understood. In this study, we have found that the p38 mitogen-activated protein kinase (MAPK) plays a key r...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2000-05, Vol.60 (9), p.2464-2472
Hauptverfasser:	SANCHEZ-PRIETO, R, ROJAS, J. M, TAYA, Y, GUTKIND, J. S
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Biological and medical sciences Chemotherapy Medical sciences mitogen-activated protein kinase p38 protein Pharmacology. Drug treatments transcription activation
Online-Zugang:	Volltext
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