aph-2 encodes a novel extracellular protein required for GLP-1-mediated signaling

In animal development, numerous cell-cell interactions are mediated by the GLP-1/LIN-12/NOTCH family of transmembrane receptors. These proteins function in a signaling pathway that appears to be conserved from nematodes to humans. We show here that the aph-2 gene is a new component of the GLP-1 sign...

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Veröffentlicht in:	Development (Cambridge) 2000-06, Vol.127 (11), p.2481-2492
Hauptverfasser:	Goutte, C, Hepler, W, Mickey, K M, Priess, J R
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals aph-2 gene APH-2 protein Base Sequence Blastomeres Caenorhabditis elegans Caenorhabditis elegans - embryology Caenorhabditis elegans Proteins DNA, Helminth GLP-1 protein Helminth Proteins - genetics Helminth Proteins - metabolism Humans Membrane Glycoproteins - metabolism Membrane Proteins - genetics Membrane Proteins - metabolism Molecular Sequence Data Mutagenesis Rabbits Receptors, Notch Signal Transduction
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