Constitutive expression of insulin-like growth factor-1 in epidermal basal cells of transgenic mice leads to spontaneous tumor promotion

Transgenic mice overexpressing insulin-like growth factor-1 (IGF-1) in the basal layer of skin epidermis were generated using the bovine keratin 5 promoter (BK5). Neonatal transgenic mice were slightly smaller at birth and exhibited early ear unfolding, wrinkled and thickened skin, and slightly enla...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2000-03, Vol.60 (6), p.1561-1570
Hauptverfasser:	DIGIOVANNI, J, BOL, D. K, WILKER, E, BELTRAN, L, CARBAJAL, S, MOATS, S, RAMIREZ, A, JORCANO, J, KIGUCHI, K
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cattle Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Epidermis - cytology Epidermis - metabolism Female Fundamental and applied biological sciences. Psychology Gene Expression Regulation Humans Insulin-Like Growth Factor I - genetics Keratins - genetics Male Mice Mice, Transgenic Mitogen-Activated Protein Kinases - metabolism Molecular and cellular biology Phosphatidylinositol 3-Kinases - metabolism Promoter Regions, Genetic - genetics Protein-Serine-Threonine Kinases Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins c-akt Receptor, IGF Type 1 - metabolism Recombinant Fusion Proteins - genetics Skin - drug effects Skin - metabolism Skin - pathology Skin Neoplasms - etiology Skin Neoplasms - genetics Tetradecanoylphorbol Acetate - pharmacology Transgenes - genetics
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