Recombinant Interleukin-2 Enhanced the Antitumor Effect of ADV/RSV-HSV-tk/ACV Therapy in a Murine Bladder Cancer Model

Background: Previous studies demonstrated the antitumor effects of IL-2 and ADV/RSV-HSV-tk in bladder tumor models. In our study, we employed the intramuscular injection of recombinant IL-2 combined with ADV/RSV-HSV-tk gene therapy in the MBT-2 murine bladder tumor model. Materials and Methods: In t...

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Veröffentlicht in:	Anticancer research 2005-07, Vol.25 (4), p.2757-2760
Hauptverfasser:	TERAO, Shuji, SHIRAKAWA, Toshiro, GODA, Kazumasa, KAMIDONO, Sadao, FUJISAWA, Masato, GOTOH, Akinobu
Format:	Artikel
Sprache:	eng
Schlagworte:	Acyclovir - pharmacokinetics Acyclovir - pharmacology Adenoviridae - genetics Animals Biological and medical sciences Cell Growth Processes - drug effects Cell Growth Processes - genetics Cell Line, Tumor Combined Modality Therapy Disease Models, Animal Drug Synergism Genetic Therapy - methods Genetic Vectors - genetics Interleukin-2 - pharmacology Medical sciences Mice Mice, Inbred C3H Nephrology. Urinary tract diseases Recombinant Proteins - pharmacology Simplexvirus - enzymology Simplexvirus - growth & development Thymidine Kinase - genetics Thymidine Kinase - metabolism Transduction, Genetic Tumors Tumors of the urinary system Urinary Bladder Neoplasms - drug therapy Urinary Bladder Neoplasms - genetics Urinary Bladder Neoplasms - pathology Urinary Bladder Neoplasms - therapy Urinary tract. Prostate gland
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