Ro60 Peptides Induce Antibodies to Similar Epitopes Shared Among Lupus-Related Autoantigens

The coexistence of autoantibodies to ribonucleoproteins (RNP) in sera of patients with systemic lupus erythematosus has been attributed to intermolecular determinant spreading among physically associated proteins. Recently, we showed that murine Ab responses to rRo60 or Ro60 peptides were diversifie...

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Veröffentlicht in:	The Journal of immunology (1950) 2000-06, Vol.164 (12), p.6655-6661
Hauptverfasser:	Deshmukh, Umesh S, Lewis, Janet E, Gaskin, Felicia, Dhakephalkar, Prashant K, Kannapell, Carol C, Waters, Samuel T, Fu, Shu Man
Format:	Artikel
Sprache:	eng
Schlagworte:	Absorption Amino Acid Sequence Animals Antigens, Heterophile - administration & dosage Antigens, Heterophile - immunology Antigens, Heterophile - metabolism Autoantibodies - biosynthesis Autoantibodies - metabolism Autoantigens - administration & dosage Autoantigens - immunology Autoantigens - metabolism Cross Reactions Crosses, Genetic Epitopes, B-Lymphocyte - immunology Epitopes, B-Lymphocyte - metabolism Female Humans Lupus Erythematosus, Systemic - immunology Mice Mice, Inbred A Mice, Inbred BALB C Mice, Inbred NZB Molecular Sequence Data Peptide Fragments - administration & dosage Peptide Fragments - immunology Peptide Fragments - metabolism Ribonucleoproteins - administration & dosage Ribonucleoproteins - immunology Ribonucleoproteins - metabolism RNA, Small Cytoplasmic Ro60 antigen
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