WRN or telomerase constructs reverse 4-nitroquinoline 1-oxide sensitivity in transformed Werner syndrome fibroblasts

WRN encodes a RecQ helicase, which is mutated in Werner syndrome. Werner syndrome is a genetic condition of young adults characterized by premature aging, limited replicative capacity of cells in vitro, and increased cancer risk. Telomerase is a reverse transcriptase that extends the G-rich strand o...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2000-05, Vol.60 (9), p.2372-2376
Hauptverfasser:	HISAMA, F. M, CHEN, Y.-H, MEYN, M. S, OSHIMA, J, WEISSMAN, S. M
Format:	Artikel
Sprache:	eng
Schlagworte:	4-nitroquinoline 1-oxide 4-Nitroquinoline-1-oxide - metabolism Animals Biological and medical sciences Blotting, Western Cell Line, Transformed COS Cells Dermatology DNA helicase DNA Helicases - genetics DNA Helicases - metabolism DNA, Complementary - metabolism DNA-Binding Proteins Dose-Response Relationship, Drug Exodeoxyribonucleases Fibroblasts - metabolism HeLa Cells Hereditary diseases of the skin. Congenital diseases of the skin. Haemangioma of the skin, of mucosae and of soft tissue Humans Medical sciences Miscellaneous Models, Genetic Molecular Sequence Data Mutagens - metabolism Mutation Ophthalmology RecQ Helicases RNA Sequence Analysis, DNA Simian virus 40 Telomerase - genetics Telomerase - metabolism Telomere - genetics TERT gene Transfection Werner Syndrome - enzymology Werner Syndrome - genetics Werner Syndrome Helicase Werner's syndrome WRN gene
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