The Transcriptional Landscape of the Mammalian Genome: The FANTOM Consortium

The Transcriptional Landscape of the Mammalian Genome: The FANTOM Consortium

This study describes comprehensive polling of transcription start and termination sites and analysis of previously unidentified full-length complementary DNAs derived from the mouse genome. We identify the 5' and 3' boundaries of 181,047 transcripts with extensive variation in transcripts...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Science (American Association for the Advancement of Science) 2005-09, Vol.309 (5740), p.1559-1563
Hauptverfasser: Carninci, P, Kasukawa, T, Katayama, S, Gough, J, Frith, M C, Maeda, N, Oyama, R, Ravasi, T, Lenhard, B, Wells, C, Kodzius, R, Shimokawa, K, Bajic, V B, Brenner, SE, Batalov, S, rest, ARR, Zavolan, M, Davis, MJ, Wilming, L G, Aidinis, V, Allen, JE, Ambesi-Impiombato, A, Apweiler, R, Aturaliya, R N, Bailey, T L, Bansal, M, Baxter, L, Beisel, K W, Bersano, T, Bono, H, Chalk, A M, Chiu, K P, Choudhary, V, Christoffels, A, Clutterbuck, DR, Crowe, M L, Dalla, E, Dalrymple, B P
Format: Artikel
Sprache:eng
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:This study describes comprehensive polling of transcription start and termination sites and analysis of previously unidentified full-length complementary DNAs derived from the mouse genome. We identify the 5' and 3' boundaries of 181,047 transcripts with extensive variation in transcripts arising from alternative promoter usage, splicing, and polyadenylation. There are 16,247 new mouse protein-coding transcripts, including 5154 encoding previously unidentified proteins. Genomic mapping of the transcriptome reveals transcriptional forests, with overlapping transcription on both strands, separated by deserts in which few transcripts are observed. The data provide a comprehensive platform for the comparative analysis of mammalian transcriptional regulation in differentiation and development.
ISSN:0036-8075
DOI:10.1126/science.1112014