Measurement of plasma gentamicin concentrations postchemical ciliary body ablation in dogs with chronic glaucoma
Objective To investigate the absorption of gentamicin into the plasma after an intravitreal injection in dogs and to report the success rate of this procedure in lowering the intraocular pressure. Animals Twenty‐four client‐owned dogs with chronic, end‐stage glaucoma. Procedures Dogs received a unil...
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| Veröffentlicht in: | Veterinary ophthalmology 2016-01, Vol.19 (1), p.57-62 |
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| creator | Rankin, Amy J. Lanuza, Rick KuKanich, Butch Crumley, William C. Pucket, Jonathan D. Allbaugh, Rachel A. Meekins, Jessica M. |
| description | Objective
To investigate the absorption of gentamicin into the plasma after an intravitreal injection in dogs and to report the success rate of this procedure in lowering the intraocular pressure.
Animals
Twenty‐four client‐owned dogs with chronic, end‐stage glaucoma.
Procedures
Dogs received a unilateral (22) or bilateral (2) intravitreal injection of 25–40 mg of gentamicin (mean ± SD dose 2.57 ± 1.65 mg/kg and range 0.61–7.50 mg/kg) and 1 mg of dexamethasone per eye. Blood samples were collected at various time points following the intravitreal injection. Plasma concentrations of gentamicin were determined by liquid chromatography and mass spectrometry.
Results
The total plasma concentration of gentamicin ranged from 0.21 to 9.71 μg/mL (mean ± SD 2.15 ± 2.03). The mean gentamicin CMAX was 2.29 μg/mL at 2.54 h with a terminal half‐life of 9.8 h. The success rate of the chemical ablation procedure was 86.4% (19/22 eyes) in dogs that had at least 1 month of follow‐up.
Conclusions
Intravitreal injection of gentamicin in eyes with chronic glaucoma resulted in detectable plasma levels in dogs and was successful in lowering the intraocular pressure in 86.4% of the eyes after the first procedure. |
| doi_str_mv | 10.1111/vop.12258 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1754525904</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1754525904</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3638-16d280db965c89a1b9aeed639d49972aa00c9dfc6a0778bba7b90351407aaa013</originalsourceid><addsrcrecordid>eNp1kE1P3DAQhq2qqHy0h_4B5GN7CNhxbMfHCtGFiq8iPo7WxPHumjpxaieF_fc1LOyNucyM5nlfaV6EvlJyQHMd_gvDAS1LXn9AO7QSrOBlWX3czFRso92UHgghjBP5CW2XXNR1zdkOGs4tpCnazvYjDnM8eEgd4EVeoXPG9diE3uQtwuhCn_AQ0miWNt_AY-O8g7jCTWhXGBr_wuAsasMi4Uc3LrFZxtA7gxceJhM6-Iy25uCT_fLa99Dtz-Obo5Pi7HJ2evTjrDBMsLqgoi1r0jZKcFMroI0Ca1vBVFspJUsAQoxq50YAkbJuGpCNyt_RikjIR8r20Le17xDD38mmUXcuGes99DZMSVPJK15yRaqMfl-jJoaUop3rIbou_6Up0c8B6xywfgk4s_uvtlPT2XZDviWagcM18Oi8Xb3vpO8ur94si7XCpdE-bRQQ_2ghmeT6_mKmf99dk4r-utc37D_MLZaE</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1754525904</pqid></control><display><type>article</type><title>Measurement of plasma gentamicin concentrations postchemical ciliary body ablation in dogs with chronic glaucoma</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Rankin, Amy J. ; Lanuza, Rick ; KuKanich, Butch ; Crumley, William C. ; Pucket, Jonathan D. ; Allbaugh, Rachel A. ; Meekins, Jessica M.</creator><creatorcontrib>Rankin, Amy J. ; Lanuza, Rick ; KuKanich, Butch ; Crumley, William C. ; Pucket, Jonathan D. ; Allbaugh, Rachel A. ; Meekins, Jessica M.</creatorcontrib><description>Objective
To investigate the absorption of gentamicin into the plasma after an intravitreal injection in dogs and to report the success rate of this procedure in lowering the intraocular pressure.
Animals
Twenty‐four client‐owned dogs with chronic, end‐stage glaucoma.
Procedures
Dogs received a unilateral (22) or bilateral (2) intravitreal injection of 25–40 mg of gentamicin (mean ± SD dose 2.57 ± 1.65 mg/kg and range 0.61–7.50 mg/kg) and 1 mg of dexamethasone per eye. Blood samples were collected at various time points following the intravitreal injection. Plasma concentrations of gentamicin were determined by liquid chromatography and mass spectrometry.
Results
The total plasma concentration of gentamicin ranged from 0.21 to 9.71 μg/mL (mean ± SD 2.15 ± 2.03). The mean gentamicin CMAX was 2.29 μg/mL at 2.54 h with a terminal half‐life of 9.8 h. The success rate of the chemical ablation procedure was 86.4% (19/22 eyes) in dogs that had at least 1 month of follow‐up.
Conclusions
Intravitreal injection of gentamicin in eyes with chronic glaucoma resulted in detectable plasma levels in dogs and was successful in lowering the intraocular pressure in 86.4% of the eyes after the first procedure.</description><identifier>ISSN: 1463-5216</identifier><identifier>EISSN: 1463-5224</identifier><identifier>DOI: 10.1111/vop.12258</identifier><identifier>PMID: 25688853</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>Animals ; Anti-Bacterial Agents - administration & dosage ; Anti-Bacterial Agents - blood ; Anti-Bacterial Agents - pharmacokinetics ; Anti-Bacterial Agents - therapeutic use ; Area Under Curve ; canine ; chemical ablation ; Ciliary Body - pathology ; ciliary body ablation ; Dog Diseases - blood ; Dog Diseases - therapy ; Dogs ; Female ; gentamicin ; Gentamicins - administration & dosage ; Gentamicins - blood ; Gentamicins - pharmacokinetics ; Gentamicins - therapeutic use ; glaucoma ; Glaucoma - therapy ; Glaucoma - veterinary ; Half-Life ; Intravitreal Injections - veterinary ; Male ; plasma</subject><ispartof>Veterinary ophthalmology, 2016-01, Vol.19 (1), p.57-62</ispartof><rights>2015 American College of Veterinary Ophthalmologists</rights><rights>2015 American College of Veterinary Ophthalmologists.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3638-16d280db965c89a1b9aeed639d49972aa00c9dfc6a0778bba7b90351407aaa013</citedby><cites>FETCH-LOGICAL-c3638-16d280db965c89a1b9aeed639d49972aa00c9dfc6a0778bba7b90351407aaa013</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fvop.12258$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fvop.12258$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25688853$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rankin, Amy J.</creatorcontrib><creatorcontrib>Lanuza, Rick</creatorcontrib><creatorcontrib>KuKanich, Butch</creatorcontrib><creatorcontrib>Crumley, William C.</creatorcontrib><creatorcontrib>Pucket, Jonathan D.</creatorcontrib><creatorcontrib>Allbaugh, Rachel A.</creatorcontrib><creatorcontrib>Meekins, Jessica M.</creatorcontrib><title>Measurement of plasma gentamicin concentrations postchemical ciliary body ablation in dogs with chronic glaucoma</title><title>Veterinary ophthalmology</title><addtitle>Vet Ophthalmol</addtitle><description>Objective
To investigate the absorption of gentamicin into the plasma after an intravitreal injection in dogs and to report the success rate of this procedure in lowering the intraocular pressure.
Animals
Twenty‐four client‐owned dogs with chronic, end‐stage glaucoma.
Procedures
Dogs received a unilateral (22) or bilateral (2) intravitreal injection of 25–40 mg of gentamicin (mean ± SD dose 2.57 ± 1.65 mg/kg and range 0.61–7.50 mg/kg) and 1 mg of dexamethasone per eye. Blood samples were collected at various time points following the intravitreal injection. Plasma concentrations of gentamicin were determined by liquid chromatography and mass spectrometry.
Results
The total plasma concentration of gentamicin ranged from 0.21 to 9.71 μg/mL (mean ± SD 2.15 ± 2.03). The mean gentamicin CMAX was 2.29 μg/mL at 2.54 h with a terminal half‐life of 9.8 h. The success rate of the chemical ablation procedure was 86.4% (19/22 eyes) in dogs that had at least 1 month of follow‐up.
Conclusions
Intravitreal injection of gentamicin in eyes with chronic glaucoma resulted in detectable plasma levels in dogs and was successful in lowering the intraocular pressure in 86.4% of the eyes after the first procedure.</description><subject>Animals</subject><subject>Anti-Bacterial Agents - administration & dosage</subject><subject>Anti-Bacterial Agents - blood</subject><subject>Anti-Bacterial Agents - pharmacokinetics</subject><subject>Anti-Bacterial Agents - therapeutic use</subject><subject>Area Under Curve</subject><subject>canine</subject><subject>chemical ablation</subject><subject>Ciliary Body - pathology</subject><subject>ciliary body ablation</subject><subject>Dog Diseases - blood</subject><subject>Dog Diseases - therapy</subject><subject>Dogs</subject><subject>Female</subject><subject>gentamicin</subject><subject>Gentamicins - administration & dosage</subject><subject>Gentamicins - blood</subject><subject>Gentamicins - pharmacokinetics</subject><subject>Gentamicins - therapeutic use</subject><subject>glaucoma</subject><subject>Glaucoma - therapy</subject><subject>Glaucoma - veterinary</subject><subject>Half-Life</subject><subject>Intravitreal Injections - veterinary</subject><subject>Male</subject><subject>plasma</subject><issn>1463-5216</issn><issn>1463-5224</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kE1P3DAQhq2qqHy0h_4B5GN7CNhxbMfHCtGFiq8iPo7WxPHumjpxaieF_fc1LOyNucyM5nlfaV6EvlJyQHMd_gvDAS1LXn9AO7QSrOBlWX3czFRso92UHgghjBP5CW2XXNR1zdkOGs4tpCnazvYjDnM8eEgd4EVeoXPG9diE3uQtwuhCn_AQ0miWNt_AY-O8g7jCTWhXGBr_wuAsasMi4Uc3LrFZxtA7gxceJhM6-Iy25uCT_fLa99Dtz-Obo5Pi7HJ2evTjrDBMsLqgoi1r0jZKcFMroI0Ca1vBVFspJUsAQoxq50YAkbJuGpCNyt_RikjIR8r20Le17xDD38mmUXcuGes99DZMSVPJK15yRaqMfl-jJoaUop3rIbou_6Up0c8B6xywfgk4s_uvtlPT2XZDviWagcM18Oi8Xb3vpO8ur94si7XCpdE-bRQQ_2ghmeT6_mKmf99dk4r-utc37D_MLZaE</recordid><startdate>201601</startdate><enddate>201601</enddate><creator>Rankin, Amy J.</creator><creator>Lanuza, Rick</creator><creator>KuKanich, Butch</creator><creator>Crumley, William C.</creator><creator>Pucket, Jonathan D.</creator><creator>Allbaugh, Rachel A.</creator><creator>Meekins, Jessica M.</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201601</creationdate><title>Measurement of plasma gentamicin concentrations postchemical ciliary body ablation in dogs with chronic glaucoma</title><author>Rankin, Amy J. ; Lanuza, Rick ; KuKanich, Butch ; Crumley, William C. ; Pucket, Jonathan D. ; Allbaugh, Rachel A. ; Meekins, Jessica M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3638-16d280db965c89a1b9aeed639d49972aa00c9dfc6a0778bba7b90351407aaa013</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Animals</topic><topic>Anti-Bacterial Agents - administration & dosage</topic><topic>Anti-Bacterial Agents - blood</topic><topic>Anti-Bacterial Agents - pharmacokinetics</topic><topic>Anti-Bacterial Agents - therapeutic use</topic><topic>Area Under Curve</topic><topic>canine</topic><topic>chemical ablation</topic><topic>Ciliary Body - pathology</topic><topic>ciliary body ablation</topic><topic>Dog Diseases - blood</topic><topic>Dog Diseases - therapy</topic><topic>Dogs</topic><topic>Female</topic><topic>gentamicin</topic><topic>Gentamicins - administration & dosage</topic><topic>Gentamicins - blood</topic><topic>Gentamicins - pharmacokinetics</topic><topic>Gentamicins - therapeutic use</topic><topic>glaucoma</topic><topic>Glaucoma - therapy</topic><topic>Glaucoma - veterinary</topic><topic>Half-Life</topic><topic>Intravitreal Injections - veterinary</topic><topic>Male</topic><topic>plasma</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rankin, Amy J.</creatorcontrib><creatorcontrib>Lanuza, Rick</creatorcontrib><creatorcontrib>KuKanich, Butch</creatorcontrib><creatorcontrib>Crumley, William C.</creatorcontrib><creatorcontrib>Pucket, Jonathan D.</creatorcontrib><creatorcontrib>Allbaugh, Rachel A.</creatorcontrib><creatorcontrib>Meekins, Jessica M.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Veterinary ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rankin, Amy J.</au><au>Lanuza, Rick</au><au>KuKanich, Butch</au><au>Crumley, William C.</au><au>Pucket, Jonathan D.</au><au>Allbaugh, Rachel A.</au><au>Meekins, Jessica M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Measurement of plasma gentamicin concentrations postchemical ciliary body ablation in dogs with chronic glaucoma</atitle><jtitle>Veterinary ophthalmology</jtitle><addtitle>Vet Ophthalmol</addtitle><date>2016-01</date><risdate>2016</risdate><volume>19</volume><issue>1</issue><spage>57</spage><epage>62</epage><pages>57-62</pages><issn>1463-5216</issn><eissn>1463-5224</eissn><abstract>Objective
To investigate the absorption of gentamicin into the plasma after an intravitreal injection in dogs and to report the success rate of this procedure in lowering the intraocular pressure.
Animals
Twenty‐four client‐owned dogs with chronic, end‐stage glaucoma.
Procedures
Dogs received a unilateral (22) or bilateral (2) intravitreal injection of 25–40 mg of gentamicin (mean ± SD dose 2.57 ± 1.65 mg/kg and range 0.61–7.50 mg/kg) and 1 mg of dexamethasone per eye. Blood samples were collected at various time points following the intravitreal injection. Plasma concentrations of gentamicin were determined by liquid chromatography and mass spectrometry.
Results
The total plasma concentration of gentamicin ranged from 0.21 to 9.71 μg/mL (mean ± SD 2.15 ± 2.03). The mean gentamicin CMAX was 2.29 μg/mL at 2.54 h with a terminal half‐life of 9.8 h. The success rate of the chemical ablation procedure was 86.4% (19/22 eyes) in dogs that had at least 1 month of follow‐up.
Conclusions
Intravitreal injection of gentamicin in eyes with chronic glaucoma resulted in detectable plasma levels in dogs and was successful in lowering the intraocular pressure in 86.4% of the eyes after the first procedure.</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>25688853</pmid><doi>10.1111/vop.12258</doi><tpages>6</tpages></addata></record> |
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| ispartof | Veterinary ophthalmology, 2016-01, Vol.19 (1), p.57-62 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Animals Anti-Bacterial Agents - administration & dosage Anti-Bacterial Agents - blood Anti-Bacterial Agents - pharmacokinetics Anti-Bacterial Agents - therapeutic use Area Under Curve canine chemical ablation Ciliary Body - pathology ciliary body ablation Dog Diseases - blood Dog Diseases - therapy Dogs Female gentamicin Gentamicins - administration & dosage Gentamicins - blood Gentamicins - pharmacokinetics Gentamicins - therapeutic use glaucoma Glaucoma - therapy Glaucoma - veterinary Half-Life Intravitreal Injections - veterinary Male plasma |
| title | Measurement of plasma gentamicin concentrations postchemical ciliary body ablation in dogs with chronic glaucoma |
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