Impact of aging and comorbidity on the efficacy of low-intensity shock wave therapy for erectile dysfunction
Objectives To evaluate the efficacy of low‐intensity shock wave therapy and to identify the predictive factors of its efficacy in Japanese patients with erectile dysfunction. Methods The present study included 57 patients with erectile dysfunction who satisfied all the following conditions: more tha...
Gespeichert in:
| Veröffentlicht in: | International journal of urology 2016-01, Vol.23 (1), p.80-84 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 84 |
|---|---|
| container_issue | 1 |
| container_start_page | 80 |
| container_title | International journal of urology |
| container_volume | 23 |
| creator | Hisasue, Shin-ichi China, Toshiyuki Horiuchi, Akira Kimura, Masaki Saito, Keisuke Isotani, Shuji Ide, Hisamitsu Muto, Satoru Yamaguchi, Raizo Horie, Shigeo |
| description | Objectives
To evaluate the efficacy of low‐intensity shock wave therapy and to identify the predictive factors of its efficacy in Japanese patients with erectile dysfunction.
Methods
The present study included 57 patients with erectile dysfunction who satisfied all the following conditions: more than 6‐months history of erectile dysfunction, sexual health inventory for men score of ≤12 without phosphodiesterase type‐5 inhibitor, erection hardness score grade 1 or 2, mean penile circumferential change by erectometer assessing sleep related erection of |
| doi_str_mv | 10.1111/iju.12955 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1754525188</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1754525188</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5235-ef03618dfe5bb7e0bb8f17c995f740ff83d5f825e771af8b211a89c8ea49c97e3</originalsourceid><addsrcrecordid>eNp10MFO3DAQBmCrKioL7aEvUPnYHgIeJ17bxwoV2BZRVSpqb5bjjMGQxIudsOTtm-0CN3wZH775pfkJ-QjsCOZ3HG7HI-BaiDdkAVXFC84q_pYsmAZdKJB8nxzkfMsYlBzUO7LPl4KB1nxB2lW3tm6g0VN7HfpravuGutjFVIcmDBONPR1ukKL3wVk3bWEbN0XoB-zzFuSb6O7oxj7gFia7nqiPiWJCN4QWaTNlP_bzP_bvyZ63bcYPT_OQXJ1--31yXlz8PFudfL0onOClKNCzcgmq8SjqWiKra-VBOq2FlxXzXpWN8IoLlBKsVzUHsEo7hbbSTkssD8nnXe46xfsR82C6kB22re0xjtmAFJXgApSa6ZcddSnmnNCbdQqdTZMBZrblmrlc87_c2X56ih3rDpsX-dzmDI53YDMfPr2eZFbfr54ji91GyAM-vmzYdGeWspTC_Lk8M79O2fLyb_nDiPIfF3aUbg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1754525188</pqid></control><display><type>article</type><title>Impact of aging and comorbidity on the efficacy of low-intensity shock wave therapy for erectile dysfunction</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Hisasue, Shin-ichi ; China, Toshiyuki ; Horiuchi, Akira ; Kimura, Masaki ; Saito, Keisuke ; Isotani, Shuji ; Ide, Hisamitsu ; Muto, Satoru ; Yamaguchi, Raizo ; Horie, Shigeo</creator><creatorcontrib>Hisasue, Shin-ichi ; China, Toshiyuki ; Horiuchi, Akira ; Kimura, Masaki ; Saito, Keisuke ; Isotani, Shuji ; Ide, Hisamitsu ; Muto, Satoru ; Yamaguchi, Raizo ; Horie, Shigeo</creatorcontrib><description>Objectives
To evaluate the efficacy of low‐intensity shock wave therapy and to identify the predictive factors of its efficacy in Japanese patients with erectile dysfunction.
Methods
The present study included 57 patients with erectile dysfunction who satisfied all the following conditions: more than 6‐months history of erectile dysfunction, sexual health inventory for men score of ≤12 without phosphodiesterase type‐5 inhibitor, erection hardness score grade 1 or 2, mean penile circumferential change by erectometer assessing sleep related erection of <25 mm and non‐neurological pathology. Patients were treated by a low‐energy shock waves generator (ED1000; Medispec, Gaithersburg, MD, USA). A total of 12 shock wave treatments were applied. Sexual health inventory for men score, erection hardness score with or without phosphodiesterase type‐5 inhibitor, and mean penile circumferential change were assessed at baseline, 1, 3 and 6 months after the termination of low‐intensity shock wave therapy.
Results
Of 57 patients who were assigned for the low‐intensity shock wave therapy trial, 56 patients were analyzed. Patients had a median age of 64 years. The sexual health inventory for men and erection hardness score (with and without phosphodiesterase type‐5 inhibitor) were significantly increased (P < 0.001) at each time‐point. The mean penile circumferential change was also increased from 13.1 to 20.2 mm after low‐intensity shock wave therapy (P < 0.001). In the multivariate analysis, age and the number of concomitant comorbidities were statistically significant predictors for the efficacy.
Conclusions
Low‐intensity shock wave therapy seems to be an effective physical therapy for erectile dysfunction. Age and comorbidities are negative predictive factors of therapeutic response.</description><identifier>ISSN: 0919-8172</identifier><identifier>EISSN: 1442-2042</identifier><identifier>DOI: 10.1111/iju.12955</identifier><identifier>PMID: 26501992</identifier><language>eng</language><publisher>Australia: Blackwell Publishing Ltd</publisher><subject>Adult ; Age Factors ; Aged ; Aged, 80 and over ; Aging - physiology ; Diabetes Complications - complications ; Dyslipidemias - complications ; erectile dysfunction ; Erectile Dysfunction - complications ; Erectile Dysfunction - physiopathology ; Erectile Dysfunction - therapy ; Humans ; Hypertension - complications ; low intensity shock wave treatment ; low-intensity shock wave therapy ; Male ; Middle Aged ; Myocardial Ischemia - complications ; Penile Erection - physiology ; Phosphodiesterase 5 Inhibitors - therapeutic use ; predictive factor ; Prospective Studies ; Severity of Illness Index ; Surveys and Questionnaires ; Treatment Outcome ; Ultrasonic Therapy</subject><ispartof>International journal of urology, 2016-01, Vol.23 (1), p.80-84</ispartof><rights>2015 The Japanese Urological Association</rights><rights>2015 The Japanese Urological Association.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5235-ef03618dfe5bb7e0bb8f17c995f740ff83d5f825e771af8b211a89c8ea49c97e3</citedby><cites>FETCH-LOGICAL-c5235-ef03618dfe5bb7e0bb8f17c995f740ff83d5f825e771af8b211a89c8ea49c97e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fiju.12955$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fiju.12955$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26501992$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hisasue, Shin-ichi</creatorcontrib><creatorcontrib>China, Toshiyuki</creatorcontrib><creatorcontrib>Horiuchi, Akira</creatorcontrib><creatorcontrib>Kimura, Masaki</creatorcontrib><creatorcontrib>Saito, Keisuke</creatorcontrib><creatorcontrib>Isotani, Shuji</creatorcontrib><creatorcontrib>Ide, Hisamitsu</creatorcontrib><creatorcontrib>Muto, Satoru</creatorcontrib><creatorcontrib>Yamaguchi, Raizo</creatorcontrib><creatorcontrib>Horie, Shigeo</creatorcontrib><title>Impact of aging and comorbidity on the efficacy of low-intensity shock wave therapy for erectile dysfunction</title><title>International journal of urology</title><addtitle>Int. J. Urol</addtitle><description>Objectives
To evaluate the efficacy of low‐intensity shock wave therapy and to identify the predictive factors of its efficacy in Japanese patients with erectile dysfunction.
Methods
The present study included 57 patients with erectile dysfunction who satisfied all the following conditions: more than 6‐months history of erectile dysfunction, sexual health inventory for men score of ≤12 without phosphodiesterase type‐5 inhibitor, erection hardness score grade 1 or 2, mean penile circumferential change by erectometer assessing sleep related erection of <25 mm and non‐neurological pathology. Patients were treated by a low‐energy shock waves generator (ED1000; Medispec, Gaithersburg, MD, USA). A total of 12 shock wave treatments were applied. Sexual health inventory for men score, erection hardness score with or without phosphodiesterase type‐5 inhibitor, and mean penile circumferential change were assessed at baseline, 1, 3 and 6 months after the termination of low‐intensity shock wave therapy.
Results
Of 57 patients who were assigned for the low‐intensity shock wave therapy trial, 56 patients were analyzed. Patients had a median age of 64 years. The sexual health inventory for men and erection hardness score (with and without phosphodiesterase type‐5 inhibitor) were significantly increased (P < 0.001) at each time‐point. The mean penile circumferential change was also increased from 13.1 to 20.2 mm after low‐intensity shock wave therapy (P < 0.001). In the multivariate analysis, age and the number of concomitant comorbidities were statistically significant predictors for the efficacy.
Conclusions
Low‐intensity shock wave therapy seems to be an effective physical therapy for erectile dysfunction. Age and comorbidities are negative predictive factors of therapeutic response.</description><subject>Adult</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Aging - physiology</subject><subject>Diabetes Complications - complications</subject><subject>Dyslipidemias - complications</subject><subject>erectile dysfunction</subject><subject>Erectile Dysfunction - complications</subject><subject>Erectile Dysfunction - physiopathology</subject><subject>Erectile Dysfunction - therapy</subject><subject>Humans</subject><subject>Hypertension - complications</subject><subject>low intensity shock wave treatment</subject><subject>low-intensity shock wave therapy</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Myocardial Ischemia - complications</subject><subject>Penile Erection - physiology</subject><subject>Phosphodiesterase 5 Inhibitors - therapeutic use</subject><subject>predictive factor</subject><subject>Prospective Studies</subject><subject>Severity of Illness Index</subject><subject>Surveys and Questionnaires</subject><subject>Treatment Outcome</subject><subject>Ultrasonic Therapy</subject><issn>0919-8172</issn><issn>1442-2042</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10MFO3DAQBmCrKioL7aEvUPnYHgIeJ17bxwoV2BZRVSpqb5bjjMGQxIudsOTtm-0CN3wZH775pfkJ-QjsCOZ3HG7HI-BaiDdkAVXFC84q_pYsmAZdKJB8nxzkfMsYlBzUO7LPl4KB1nxB2lW3tm6g0VN7HfpravuGutjFVIcmDBONPR1ukKL3wVk3bWEbN0XoB-zzFuSb6O7oxj7gFia7nqiPiWJCN4QWaTNlP_bzP_bvyZ63bcYPT_OQXJ1--31yXlz8PFudfL0onOClKNCzcgmq8SjqWiKra-VBOq2FlxXzXpWN8IoLlBKsVzUHsEo7hbbSTkssD8nnXe46xfsR82C6kB22re0xjtmAFJXgApSa6ZcddSnmnNCbdQqdTZMBZrblmrlc87_c2X56ih3rDpsX-dzmDI53YDMfPr2eZFbfr54ji91GyAM-vmzYdGeWspTC_Lk8M79O2fLyb_nDiPIfF3aUbg</recordid><startdate>201601</startdate><enddate>201601</enddate><creator>Hisasue, Shin-ichi</creator><creator>China, Toshiyuki</creator><creator>Horiuchi, Akira</creator><creator>Kimura, Masaki</creator><creator>Saito, Keisuke</creator><creator>Isotani, Shuji</creator><creator>Ide, Hisamitsu</creator><creator>Muto, Satoru</creator><creator>Yamaguchi, Raizo</creator><creator>Horie, Shigeo</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201601</creationdate><title>Impact of aging and comorbidity on the efficacy of low-intensity shock wave therapy for erectile dysfunction</title><author>Hisasue, Shin-ichi ; China, Toshiyuki ; Horiuchi, Akira ; Kimura, Masaki ; Saito, Keisuke ; Isotani, Shuji ; Ide, Hisamitsu ; Muto, Satoru ; Yamaguchi, Raizo ; Horie, Shigeo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5235-ef03618dfe5bb7e0bb8f17c995f740ff83d5f825e771af8b211a89c8ea49c97e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adult</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Aging - physiology</topic><topic>Diabetes Complications - complications</topic><topic>Dyslipidemias - complications</topic><topic>erectile dysfunction</topic><topic>Erectile Dysfunction - complications</topic><topic>Erectile Dysfunction - physiopathology</topic><topic>Erectile Dysfunction - therapy</topic><topic>Humans</topic><topic>Hypertension - complications</topic><topic>low intensity shock wave treatment</topic><topic>low-intensity shock wave therapy</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Myocardial Ischemia - complications</topic><topic>Penile Erection - physiology</topic><topic>Phosphodiesterase 5 Inhibitors - therapeutic use</topic><topic>predictive factor</topic><topic>Prospective Studies</topic><topic>Severity of Illness Index</topic><topic>Surveys and Questionnaires</topic><topic>Treatment Outcome</topic><topic>Ultrasonic Therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hisasue, Shin-ichi</creatorcontrib><creatorcontrib>China, Toshiyuki</creatorcontrib><creatorcontrib>Horiuchi, Akira</creatorcontrib><creatorcontrib>Kimura, Masaki</creatorcontrib><creatorcontrib>Saito, Keisuke</creatorcontrib><creatorcontrib>Isotani, Shuji</creatorcontrib><creatorcontrib>Ide, Hisamitsu</creatorcontrib><creatorcontrib>Muto, Satoru</creatorcontrib><creatorcontrib>Yamaguchi, Raizo</creatorcontrib><creatorcontrib>Horie, Shigeo</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of urology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hisasue, Shin-ichi</au><au>China, Toshiyuki</au><au>Horiuchi, Akira</au><au>Kimura, Masaki</au><au>Saito, Keisuke</au><au>Isotani, Shuji</au><au>Ide, Hisamitsu</au><au>Muto, Satoru</au><au>Yamaguchi, Raizo</au><au>Horie, Shigeo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impact of aging and comorbidity on the efficacy of low-intensity shock wave therapy for erectile dysfunction</atitle><jtitle>International journal of urology</jtitle><addtitle>Int. J. Urol</addtitle><date>2016-01</date><risdate>2016</risdate><volume>23</volume><issue>1</issue><spage>80</spage><epage>84</epage><pages>80-84</pages><issn>0919-8172</issn><eissn>1442-2042</eissn><abstract>Objectives
To evaluate the efficacy of low‐intensity shock wave therapy and to identify the predictive factors of its efficacy in Japanese patients with erectile dysfunction.
Methods
The present study included 57 patients with erectile dysfunction who satisfied all the following conditions: more than 6‐months history of erectile dysfunction, sexual health inventory for men score of ≤12 without phosphodiesterase type‐5 inhibitor, erection hardness score grade 1 or 2, mean penile circumferential change by erectometer assessing sleep related erection of <25 mm and non‐neurological pathology. Patients were treated by a low‐energy shock waves generator (ED1000; Medispec, Gaithersburg, MD, USA). A total of 12 shock wave treatments were applied. Sexual health inventory for men score, erection hardness score with or without phosphodiesterase type‐5 inhibitor, and mean penile circumferential change were assessed at baseline, 1, 3 and 6 months after the termination of low‐intensity shock wave therapy.
Results
Of 57 patients who were assigned for the low‐intensity shock wave therapy trial, 56 patients were analyzed. Patients had a median age of 64 years. The sexual health inventory for men and erection hardness score (with and without phosphodiesterase type‐5 inhibitor) were significantly increased (P < 0.001) at each time‐point. The mean penile circumferential change was also increased from 13.1 to 20.2 mm after low‐intensity shock wave therapy (P < 0.001). In the multivariate analysis, age and the number of concomitant comorbidities were statistically significant predictors for the efficacy.
Conclusions
Low‐intensity shock wave therapy seems to be an effective physical therapy for erectile dysfunction. Age and comorbidities are negative predictive factors of therapeutic response.</abstract><cop>Australia</cop><pub>Blackwell Publishing Ltd</pub><pmid>26501992</pmid><doi>10.1111/iju.12955</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0919-8172 |
| ispartof | International journal of urology, 2016-01, Vol.23 (1), p.80-84 |
| issn | 0919-8172 1442-2042 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1754525188 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adult Age Factors Aged Aged, 80 and over Aging - physiology Diabetes Complications - complications Dyslipidemias - complications erectile dysfunction Erectile Dysfunction - complications Erectile Dysfunction - physiopathology Erectile Dysfunction - therapy Humans Hypertension - complications low intensity shock wave treatment low-intensity shock wave therapy Male Middle Aged Myocardial Ischemia - complications Penile Erection - physiology Phosphodiesterase 5 Inhibitors - therapeutic use predictive factor Prospective Studies Severity of Illness Index Surveys and Questionnaires Treatment Outcome Ultrasonic Therapy |
| title | Impact of aging and comorbidity on the efficacy of low-intensity shock wave therapy for erectile dysfunction |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-26T18%3A48%3A51IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Impact%20of%20aging%20and%20comorbidity%20on%20the%20efficacy%20of%20low-intensity%20shock%20wave%20therapy%20for%20erectile%20dysfunction&rft.jtitle=International%20journal%20of%20urology&rft.au=Hisasue,%20Shin-ichi&rft.date=2016-01&rft.volume=23&rft.issue=1&rft.spage=80&rft.epage=84&rft.pages=80-84&rft.issn=0919-8172&rft.eissn=1442-2042&rft_id=info:doi/10.1111/iju.12955&rft_dat=%3Cproquest_cross%3E1754525188%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1754525188&rft_id=info:pmid/26501992&rfr_iscdi=true |