Aβ25–35 Suppresses Mitochondrial Biogenesis in Primary Hippocampal Neurons

Mitochondrial biogenesis is involved in the regulation of mitochondrial content, morphology, and function. Impaired mitochondrial biogenesis has been observed in Alzheimer’s disease. Amyloid-β (Aβ) has been shown to cause mitochondrial dysfunction in cultured neurons, but its role in mitochondrial b...

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Veröffentlicht in:	Cellular and molecular neurobiology 2016, Vol.36 (1), p.83-91
Hauptverfasser:	Dong, Weiguo, Wang, Feng, Guo, Wanqing, Zheng, Xuehua, Chen, Yue, Zhang, Wenguang, Shi, Hong
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation - drug effects AMP-Activated Protein Kinases - metabolism Amyloid beta-Peptides - toxicity Animals Biomedical and Life Sciences Biomedicine Cell Biology Cell Death - drug effects Cell Survival - drug effects Cells, Cultured DNA, Mitochondrial - genetics Down-Regulation - drug effects Gene Dosage Hippocampus - cytology Mitochondria - drug effects Mitochondria - metabolism Neurobiology Neurons - cytology Neurons - drug effects Neurons - metabolism Neurosciences Organelle Biogenesis Original Research Peptide Fragments - toxicity Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha Phosphorylation - drug effects Rats, Sprague-Dawley RNA, Messenger - genetics RNA, Messenger - metabolism Sirtuin 1 - metabolism Transcription Factors - metabolism
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