Malignant transformation of diffuse astrocytoma to glioblastoma associated with newly developed BRAF V600E mutation

A 29-year-old man presented with scintillation scotoma. MR imaging demonstrated a diffuse lesion in right parahippocampal gyrus. He underwent a biopsy, and the diagnosis was diffuse astrocytoma. Because of enlargement and new areas of gadolinium enhancement, the tumor was resected 18 months after bi...

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Veröffentlicht in:	Brain tumor pathology 2016-01, Vol.33 (1), p.50-56
Hauptverfasser:	Kanamori, Masayuki, Suzuki, Hiroyoshi, Takei, Hidehiro, Sonoda, Yukihiko, Uenohara, Hiroshi, Tominaga, Teiji
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Astrocytoma - diagnosis Astrocytoma - genetics Brain Neoplasms - diagnosis Brain Neoplasms - genetics Brain Neoplasms - pathology Cell Transformation, Neoplastic - genetics Cell Transformation, Neoplastic - pathology Cyclin-Dependent Kinase Inhibitor p16 - genetics Gene Deletion Glioblastoma - diagnosis Glioblastoma - genetics Humans Magnetic Resonance Imaging Male Mutation Proto-Oncogene Proteins B-raf - genetics
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