Trimethylated chitosans as non-viral gene delivery vectors: Cytotoxicity and transfection efficiency

Chitosans are linear polysaccharides of natural origin that show potential as carriers in drug and gene delivery. Introducing quaternisation on the chitosan backbone renders the polymer soluble over a wider pH range and confers controlled cationic character. This study aims to investigate the effect...

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Veröffentlicht in:	Journal of controlled release 2005-04, Vol.103 (3), p.643-653
Hauptverfasser:	Kean, Thomas, Roth, Susanne, Thanou, Maya
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cell Line, Tumor Cell Survival - drug effects Cercopithecus aethiops Chitosan - chemistry Chitosan - toxicity COS Cells Cytotoxicity DNA - administration & dosage DNA - chemistry Dose-Response Relationship, Drug Excipients Female Gene delivery Gene Transfer Techniques General pharmacology Genes, Reporter Humans Luciferases - genetics Medical sciences Methylation Neoplasms - genetics Neoplasms - therapy Oligomers Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Polymers Transfection Trimethyl chitosan
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