Diverse Effect of Tributyltin on Apoptosis in PC12 Cells
It has not been fully elucidated how endocrine-disrupting chemicals disrupt hormone functions or how strong their effects are compared with natural hormones. There is little information concerning the effects of tributyltin (TBT), one of the endocrine disrupters on living organisms. Although TBT at...
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| Veröffentlicht in: | Biochemical and biophysical research communications 2000-06, Vol.272 (2), p.557-562 |
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| container_title | Biochemical and biophysical research communications |
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| creator | Yamanoshita, Osamu Kurasaki, Masaaki Saito, Takeshi Takahasi, Kyoko Sasaki, Hiroko Hosokawa, Toshiyuki Okabe, Masashi Mochida, Jyunko Iwakuma, Toshio |
| description | It has not been fully elucidated how endocrine-disrupting chemicals disrupt hormone functions or how strong their effects are compared with natural hormones. There is little information concerning the effects of tributyltin (TBT), one of the endocrine disrupters on living organisms. Although TBT at high cocentration induced apoptosis in PC12 cells, TBT at low concentration inhibited the DNA fragmentation in the cells cultured in serum-free medium or in medium containing 6-hydroxydopamine. The cell viability grown in both medium conditions increased after treatment with TBT. These findings suggest that TBT exerted a apoptosis-inducing and -inhibiting effect. These diverse effect of TBT on apoptosis would cause serious damages on cell differentiation. |
| doi_str_mv | 10.1006/bbrc.2000.2810 |
| format | Article |
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There is little information concerning the effects of tributyltin (TBT), one of the endocrine disrupters on living organisms. Although TBT at high cocentration induced apoptosis in PC12 cells, TBT at low concentration inhibited the DNA fragmentation in the cells cultured in serum-free medium or in medium containing 6-hydroxydopamine. The cell viability grown in both medium conditions increased after treatment with TBT. These findings suggest that TBT exerted a apoptosis-inducing and -inhibiting effect. These diverse effect of TBT on apoptosis would cause serious damages on cell differentiation.</description><identifier>ISSN: 0006-291X</identifier><identifier>EISSN: 1090-2104</identifier><identifier>DOI: 10.1006/bbrc.2000.2810</identifier><identifier>PMID: 10833451</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; apoptosis ; Apoptosis - drug effects ; bcl-2-Associated X Protein ; bcl-Associated Death Protein ; Carrier Proteins - metabolism ; Cell Differentiation - drug effects ; Cell Nucleus - drug effects ; Cell Nucleus - metabolism ; Cell Survival - drug effects ; Culture Media, Serum-Free ; differentiation ; DNA Fragmentation - drug effects ; Dose-Response Relationship, Drug ; endocrine disrupter ; Oxidopamine - antagonists & inhibitors ; Oxidopamine - pharmacology ; PC12 ; PC12 Cells ; Proto-Oncogene Proteins - metabolism ; Proto-Oncogene Proteins c-bcl-2 - metabolism ; Rats ; Tin - metabolism ; Trialkyltin Compounds - toxicity ; tributyltin ; Tumor Suppressor Protein p53 - metabolism ; TUNEL</subject><ispartof>Biochemical and biophysical research communications, 2000-06, Vol.272 (2), p.557-562</ispartof><rights>2000 Academic Press</rights><rights>Copyright 2000 Academic Press.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c437t-c25fc4885ba54cd8f959f35a3f8648730574edc2f82825ba26df327856376be93</citedby><cites>FETCH-LOGICAL-c437t-c25fc4885ba54cd8f959f35a3f8648730574edc2f82825ba26df327856376be93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1006/bbrc.2000.2810$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3541,27915,27916,45986</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10833451$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yamanoshita, Osamu</creatorcontrib><creatorcontrib>Kurasaki, Masaaki</creatorcontrib><creatorcontrib>Saito, Takeshi</creatorcontrib><creatorcontrib>Takahasi, Kyoko</creatorcontrib><creatorcontrib>Sasaki, Hiroko</creatorcontrib><creatorcontrib>Hosokawa, Toshiyuki</creatorcontrib><creatorcontrib>Okabe, Masashi</creatorcontrib><creatorcontrib>Mochida, Jyunko</creatorcontrib><creatorcontrib>Iwakuma, Toshio</creatorcontrib><title>Diverse Effect of Tributyltin on Apoptosis in PC12 Cells</title><title>Biochemical and biophysical research communications</title><addtitle>Biochem Biophys Res Commun</addtitle><description>It has not been fully elucidated how endocrine-disrupting chemicals disrupt hormone functions or how strong their effects are compared with natural hormones. There is little information concerning the effects of tributyltin (TBT), one of the endocrine disrupters on living organisms. Although TBT at high cocentration induced apoptosis in PC12 cells, TBT at low concentration inhibited the DNA fragmentation in the cells cultured in serum-free medium or in medium containing 6-hydroxydopamine. The cell viability grown in both medium conditions increased after treatment with TBT. These findings suggest that TBT exerted a apoptosis-inducing and -inhibiting effect. These diverse effect of TBT on apoptosis would cause serious damages on cell differentiation.</description><subject>Animals</subject><subject>apoptosis</subject><subject>Apoptosis - drug effects</subject><subject>bcl-2-Associated X Protein</subject><subject>bcl-Associated Death Protein</subject><subject>Carrier Proteins - metabolism</subject><subject>Cell Differentiation - drug effects</subject><subject>Cell Nucleus - drug effects</subject><subject>Cell Nucleus - metabolism</subject><subject>Cell Survival - drug effects</subject><subject>Culture Media, Serum-Free</subject><subject>differentiation</subject><subject>DNA Fragmentation - drug effects</subject><subject>Dose-Response Relationship, Drug</subject><subject>endocrine disrupter</subject><subject>Oxidopamine - antagonists & inhibitors</subject><subject>Oxidopamine - pharmacology</subject><subject>PC12</subject><subject>PC12 Cells</subject><subject>Proto-Oncogene Proteins - metabolism</subject><subject>Proto-Oncogene Proteins c-bcl-2 - metabolism</subject><subject>Rats</subject><subject>Tin - metabolism</subject><subject>Trialkyltin Compounds - toxicity</subject><subject>tributyltin</subject><subject>Tumor Suppressor Protein p53 - metabolism</subject><subject>TUNEL</subject><issn>0006-291X</issn><issn>1090-2104</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kD1PwzAQhi0EoqWwMqJMbAnnr8QZq1I-pEowFInNShxbMkrjYCeV-Pc4SgcWFp98eu7V3YPQLYYMA-QPde1VRgAgIwLDGVpiKCElGNg5WsZ2npISfy7QVQhfABizvLxECwyCUsbxEolHe9Q-6GRrjFZD4kyy97Yeh592sF3iumTdu35wwYYk_t83mCQb3bbhGl2Yqg365lRX6ONpu9-8pLu359fNepcqRoshVYQbxYTgdcWZaoQpeWkor6gRORMFBV4w3ShiBBEkQiRvDCWF4Dkt8lqXdIXu59zeu-9Rh0EebFBxg6rTbgwSF5yR-EQwm0HlXQheG9l7e6j8j8QgJ1dyciUnV3JyFQfuTsljfdDNH3yWEwExAzred7Tay6Cs7pRurI-uZOPsf9m_Qcd1yw</recordid><startdate>20000607</startdate><enddate>20000607</enddate><creator>Yamanoshita, Osamu</creator><creator>Kurasaki, Masaaki</creator><creator>Saito, Takeshi</creator><creator>Takahasi, Kyoko</creator><creator>Sasaki, Hiroko</creator><creator>Hosokawa, Toshiyuki</creator><creator>Okabe, Masashi</creator><creator>Mochida, Jyunko</creator><creator>Iwakuma, Toshio</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope></search><sort><creationdate>20000607</creationdate><title>Diverse Effect of Tributyltin on Apoptosis in PC12 Cells</title><author>Yamanoshita, Osamu ; 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There is little information concerning the effects of tributyltin (TBT), one of the endocrine disrupters on living organisms. Although TBT at high cocentration induced apoptosis in PC12 cells, TBT at low concentration inhibited the DNA fragmentation in the cells cultured in serum-free medium or in medium containing 6-hydroxydopamine. The cell viability grown in both medium conditions increased after treatment with TBT. These findings suggest that TBT exerted a apoptosis-inducing and -inhibiting effect. These diverse effect of TBT on apoptosis would cause serious damages on cell differentiation.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>10833451</pmid><doi>10.1006/bbrc.2000.2810</doi><tpages>6</tpages></addata></record> |
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| subjects | Animals apoptosis Apoptosis - drug effects bcl-2-Associated X Protein bcl-Associated Death Protein Carrier Proteins - metabolism Cell Differentiation - drug effects Cell Nucleus - drug effects Cell Nucleus - metabolism Cell Survival - drug effects Culture Media, Serum-Free differentiation DNA Fragmentation - drug effects Dose-Response Relationship, Drug endocrine disrupter Oxidopamine - antagonists & inhibitors Oxidopamine - pharmacology PC12 PC12 Cells Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins c-bcl-2 - metabolism Rats Tin - metabolism Trialkyltin Compounds - toxicity tributyltin Tumor Suppressor Protein p53 - metabolism TUNEL |
| title | Diverse Effect of Tributyltin on Apoptosis in PC12 Cells |
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