Prognostic Impact of Novel Molecular Subtypes of Small Intestinal Neuroendocrine Tumor

Small intestinal neuroendocrine tumors (SINET) are the commonest malignancy of the small intestine; however, underlying pathogenic mechanisms remain poorly characterized. Whole-genome and -exome sequencing has demonstrated that SINETs are mutationally quiet, with the most frequent known mutation in...

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Veröffentlicht in:	Clinical cancer research 2016-01, Vol.22 (1), p.250-258
Hauptverfasser:	Karpathakis, Anna, Dibra, Harpreet, Pipinikas, Chistodoulos, Feber, Andrew, Morris, Tiffany, Francis, Joshua, Oukrif, Dahmane, Mandair, Dalvinder, Pericleous, Marinos, Mohmaduvesh, Mullan, Serra, Stefano, Ogunbiyi, Olagunju, Novelli, Marco, Luong, TuVinh, Asa, Sylvia L, Kulke, Matthew, Toumpanakis, Christos, Meyer, Tim, Caplin, Martyn, Meyerson, Matthew, Beck, Stephan, Thirlwell, Christina
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Chromosomes, Human, Pair 18 Cluster Analysis Computational Biology - methods Cyclin-Dependent Kinase Inhibitor p27 - genetics DNA Copy Number Variations DNA Methylation DNA Mutational Analysis Epigenesis, Genetic Exome Female Gene Expression Profiling High-Throughput Nucleotide Sequencing Humans Intestinal Neoplasms - diagnosis Intestinal Neoplasms - genetics Intestinal Neoplasms - mortality Intestine, Small - metabolism Intestine, Small - pathology Male Middle Aged Mutation Neoplasm Metastasis Neoplasm Staging Neuroendocrine Tumors - diagnosis Neuroendocrine Tumors - genetics Neuroendocrine Tumors - mortality Prognosis Reproducibility of Results
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