No association of oral lichen planus and hepatitis C virus infection in central Germany

No association of oral lichen planus and hepatitis C virus infection in central Germany

Objectives Co-occurrence of oral lichen planus (OLP) and chronic hepatitis C virus (HCV) infection suggests a strong association, but the relation between mucocutaneus, autoimmune lichen planus and HCV infection remains unclear. In areas with higher prevalence of HCV infection in general population,...

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Veröffentlicht in:Clinical oral investigations 2016-01, Vol.20 (1), p.193-197
Hauptverfasser: Remmerbach, Torsten W., Liese, Jan, Krause, Sarah, Schiefke, Ingolf, Schiefke, Franziska, Maier, Melanie, Liebert, Uwe G.
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Sprache:eng
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Cross-Sectional Studies
Dentistry
Female
Germany - epidemiology
Hepatitis C - epidemiology
Humans
Lichen Planus, Oral - epidemiology
Male
Medicine
Middle Aged
Prevalence
Real-Time Polymerase Chain Reaction
Short Communication
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container_end_page 197
container_issue 1
container_start_page 193
container_title Clinical oral investigations
container_volume 20
creator Remmerbach, Torsten W.
Liese, Jan
Krause, Sarah
Schiefke, Ingolf
Schiefke, Franziska
Maier, Melanie
Liebert, Uwe G.
description Objectives Co-occurrence of oral lichen planus (OLP) and chronic hepatitis C virus (HCV) infection suggests a strong association, but the relation between mucocutaneus, autoimmune lichen planus and HCV infection remains unclear. In areas with higher prevalence of HCV infection in general population, like Japan and southern Europe, 20 to 40 % of patients with OLP test positive for anti-HCV antibodies, whereas in German populations, a co-occurrence of 4.2 to 16 % was reported. Material and methods We screened 143 patients with histopathologically proven OLP for prevalence of anti-HCV antibodies. Additionally, we examined 51 anti-HCV-positive subjects with current or past HCV infection for clinical symptoms of OLP. In all patients, confirmatory diagnosis was made by the detection of HCV RNA via reverse transcription-polymerase chain reaction (RT-PCR). A randomized control group comprised 109 blood sera samples of patients without any characteristics of OLP. Results The results of all patients showed no co-occurrence in either cohort. Conclusion In conclusion, no association between oral lichen planus and chronic HCV infection in our study population was found. Clinical relevance Anti-HCV antibody screening in patients with confirmed oral lichen planus is not indicated routinely in central Germany.
doi_str_mv 10.1007/s00784-015-1602-5
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In areas with higher prevalence of HCV infection in general population, like Japan and southern Europe, 20 to 40 % of patients with OLP test positive for anti-HCV antibodies, whereas in German populations, a co-occurrence of 4.2 to 16 % was reported. Material and methods We screened 143 patients with histopathologically proven OLP for prevalence of anti-HCV antibodies. Additionally, we examined 51 anti-HCV-positive subjects with current or past HCV infection for clinical symptoms of OLP. In all patients, confirmatory diagnosis was made by the detection of HCV RNA via reverse transcription-polymerase chain reaction (RT-PCR). A randomized control group comprised 109 blood sera samples of patients without any characteristics of OLP. Results The results of all patients showed no co-occurrence in either cohort. Conclusion In conclusion, no association between oral lichen planus and chronic HCV infection in our study population was found. Clinical relevance Anti-HCV antibody screening in patients with confirmed oral lichen planus is not indicated routinely in central Germany.</description><identifier>ISSN: 1432-6981</identifier><identifier>EISSN: 1436-3771</identifier><identifier>DOI: 10.1007/s00784-015-1602-5</identifier><identifier>PMID: 26411858</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Cross-Sectional Studies ; Dentistry ; Female ; Germany - epidemiology ; Hepatitis C - epidemiology ; Humans ; Lichen Planus, Oral - epidemiology ; Male ; Medicine ; Middle Aged ; Prevalence ; Real-Time Polymerase Chain Reaction ; Short Communication</subject><ispartof>Clinical oral investigations, 2016-01, Vol.20 (1), p.193-197</ispartof><rights>Springer-Verlag Berlin Heidelberg 2015</rights><rights>Springer-Verlag Berlin Heidelberg 2016</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c442t-99b220ff467927ef4ab53103972e9a8ff1c8ba4ad05da0f1ad18607432406ffc3</citedby><cites>FETCH-LOGICAL-c442t-99b220ff467927ef4ab53103972e9a8ff1c8ba4ad05da0f1ad18607432406ffc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00784-015-1602-5$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00784-015-1602-5$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26411858$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Remmerbach, Torsten W.</creatorcontrib><creatorcontrib>Liese, Jan</creatorcontrib><creatorcontrib>Krause, Sarah</creatorcontrib><creatorcontrib>Schiefke, Ingolf</creatorcontrib><creatorcontrib>Schiefke, Franziska</creatorcontrib><creatorcontrib>Maier, Melanie</creatorcontrib><creatorcontrib>Liebert, Uwe G.</creatorcontrib><title>No association of oral lichen planus and hepatitis C virus infection in central Germany</title><title>Clinical oral investigations</title><addtitle>Clin Oral Invest</addtitle><addtitle>Clin Oral Investig</addtitle><description>Objectives Co-occurrence of oral lichen planus (OLP) and chronic hepatitis C virus (HCV) infection suggests a strong association, but the relation between mucocutaneus, autoimmune lichen planus and HCV infection remains unclear. In areas with higher prevalence of HCV infection in general population, like Japan and southern Europe, 20 to 40 % of patients with OLP test positive for anti-HCV antibodies, whereas in German populations, a co-occurrence of 4.2 to 16 % was reported. Material and methods We screened 143 patients with histopathologically proven OLP for prevalence of anti-HCV antibodies. Additionally, we examined 51 anti-HCV-positive subjects with current or past HCV infection for clinical symptoms of OLP. In all patients, confirmatory diagnosis was made by the detection of HCV RNA via reverse transcription-polymerase chain reaction (RT-PCR). A randomized control group comprised 109 blood sera samples of patients without any characteristics of OLP. Results The results of all patients showed no co-occurrence in either cohort. Conclusion In conclusion, no association between oral lichen planus and chronic HCV infection in our study population was found. 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Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical oral investigations</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Remmerbach, Torsten W.</au><au>Liese, Jan</au><au>Krause, Sarah</au><au>Schiefke, Ingolf</au><au>Schiefke, Franziska</au><au>Maier, Melanie</au><au>Liebert, Uwe G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>No association of oral lichen planus and hepatitis C virus infection in central Germany</atitle><jtitle>Clinical oral investigations</jtitle><stitle>Clin Oral Invest</stitle><addtitle>Clin Oral Investig</addtitle><date>2016-01-01</date><risdate>2016</risdate><volume>20</volume><issue>1</issue><spage>193</spage><epage>197</epage><pages>193-197</pages><issn>1432-6981</issn><eissn>1436-3771</eissn><abstract>Objectives Co-occurrence of oral lichen planus (OLP) and chronic hepatitis C virus (HCV) infection suggests a strong association, but the relation between mucocutaneus, autoimmune lichen planus and HCV infection remains unclear. In areas with higher prevalence of HCV infection in general population, like Japan and southern Europe, 20 to 40 % of patients with OLP test positive for anti-HCV antibodies, whereas in German populations, a co-occurrence of 4.2 to 16 % was reported. Material and methods We screened 143 patients with histopathologically proven OLP for prevalence of anti-HCV antibodies. Additionally, we examined 51 anti-HCV-positive subjects with current or past HCV infection for clinical symptoms of OLP. In all patients, confirmatory diagnosis was made by the detection of HCV RNA via reverse transcription-polymerase chain reaction (RT-PCR). A randomized control group comprised 109 blood sera samples of patients without any characteristics of OLP. Results The results of all patients showed no co-occurrence in either cohort. Conclusion In conclusion, no association between oral lichen planus and chronic HCV infection in our study population was found. Clinical relevance Anti-HCV antibody screening in patients with confirmed oral lichen planus is not indicated routinely in central Germany.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>26411858</pmid><doi>10.1007/s00784-015-1602-5</doi><tpages>5</tpages></addata></record>
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subjects Cross-Sectional Studies
Dentistry
Female
Germany - epidemiology
Hepatitis C - epidemiology
Humans
Lichen Planus, Oral - epidemiology
Male
Medicine
Middle Aged
Prevalence
Real-Time Polymerase Chain Reaction
Short Communication
title No association of oral lichen planus and hepatitis C virus infection in central Germany
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