Allium vegetables and upper aerodigestive tract cancers: a meta-analysis of observational studies
Scope To provide updated quantitative overall estimations of the relation between total allium, garlic, and onion intake on the risk of cancer of the upper aerodigestive tract (UADT). Methods and results We combined data of published observational studies (21 case–control and four cohort studies), u...
Gespeichert in:
| Veröffentlicht in: | Molecular nutrition & food research 2016-01, Vol.60 (1), p.212-222 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 222 |
|---|---|
| container_issue | 1 |
| container_start_page | 212 |
| container_title | Molecular nutrition & food research |
| container_volume | 60 |
| creator | Guercio, Valentina Turati, Federica La Vecchia, Carlo Galeone, Carlotta Tavani, Alessandra |
| description | Scope
To provide updated quantitative overall estimations of the relation between total allium, garlic, and onion intake on the risk of cancer of the upper aerodigestive tract (UADT).
Methods and results
We combined data of published observational studies (21 case–control and four cohort studies), using a meta‐analytic approach and random effects models. The overall relative risks (RR) and 95% confidence intervals (CIs) for the squamous cell carcinoma of the UADT were 0.79 (95% CI 0.56–1.11) for total allium, 0.74 (95% CI 0.57–0.95) for garlic, and 0.72 (95% CI 0.57–0.91) for onion for the highest versus the lowest consumption. The inverse relation was apparently stronger in case–control studies (RR 0.56, 95% CI 0.38–0.83 for total allium), in Chinese studies (RR 0.67, 95% CI 0.45–0.98 for garlic intake), and for esophageal than for head and neck cancers. Apparently, there was no relation between allium vegetable intake and adenocarcinoma of the esophagus.
Conclusion
We found a moderate inverse association between allium vegetable intake and the risk of squamous cell carcinoma of the UADT in case–control studies. The relation was unclear in cohort studies and for adenocarcinoma of the esophagus. |
| doi_str_mv | 10.1002/mnfr.201500587 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1754086806</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1754086806</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4487-e427281aea9a9feb3ab75b3e0684c0cf6f9384211a130fc62d4deb59df8a18e63</originalsourceid><addsrcrecordid>eNqFkElvFDEQRi0EIuuVI_KRSw_e280tCswEKQQJZTla1e5yZOhlsLsnmX-fHk2YK6cqld73qfQI-cDZgjMmPnd9SAvBuGZM2_INOeaGy0JxKd8edqGPyEnOvxmTXCj5nhwJo4xiRh8TuGjbOHV0g484Qt1iptA3dFqvMVHANDTxEfMYN0jHBH6kHnqPKX-hQLs5UUAP7TbHTIdAhzpj2sAYh_lI8zg1EfMZeRegzXj-Ok_J3fLb7eVVcf1z9f3y4rrwStmyQCVKYTkgVFAFrCXUpa4lMmOVZz6YUEmrBOfAJQveiEY1WOuqCRa4RSNPyad97zoNf6f5Z9fF7LFtocdhyo6XWjFrLNuhiz3q05BzwuDWKXaQto4zt9PqdlrdQesc-PjaPdUdNgf8n8cZUHvgKba4_U-d-3Gz_CU03_UW-1jMIz4fYpD-OFPKUruHm5Vbfb1fsluuXSVfAN9ZlBM</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1754086806</pqid></control><display><type>article</type><title>Allium vegetables and upper aerodigestive tract cancers: a meta-analysis of observational studies</title><source>MEDLINE</source><source>Wiley Online Library All Journals</source><creator>Guercio, Valentina ; Turati, Federica ; La Vecchia, Carlo ; Galeone, Carlotta ; Tavani, Alessandra</creator><creatorcontrib>Guercio, Valentina ; Turati, Federica ; La Vecchia, Carlo ; Galeone, Carlotta ; Tavani, Alessandra</creatorcontrib><description>Scope
To provide updated quantitative overall estimations of the relation between total allium, garlic, and onion intake on the risk of cancer of the upper aerodigestive tract (UADT).
Methods and results
We combined data of published observational studies (21 case–control and four cohort studies), using a meta‐analytic approach and random effects models. The overall relative risks (RR) and 95% confidence intervals (CIs) for the squamous cell carcinoma of the UADT were 0.79 (95% CI 0.56–1.11) for total allium, 0.74 (95% CI 0.57–0.95) for garlic, and 0.72 (95% CI 0.57–0.91) for onion for the highest versus the lowest consumption. The inverse relation was apparently stronger in case–control studies (RR 0.56, 95% CI 0.38–0.83 for total allium), in Chinese studies (RR 0.67, 95% CI 0.45–0.98 for garlic intake), and for esophageal than for head and neck cancers. Apparently, there was no relation between allium vegetable intake and adenocarcinoma of the esophagus.
Conclusion
We found a moderate inverse association between allium vegetable intake and the risk of squamous cell carcinoma of the UADT in case–control studies. The relation was unclear in cohort studies and for adenocarcinoma of the esophagus.</description><identifier>ISSN: 1613-4125</identifier><identifier>EISSN: 1613-4133</identifier><identifier>DOI: 10.1002/mnfr.201500587</identifier><identifier>PMID: 26464065</identifier><language>eng</language><publisher>Germany: Blackwell Publishing Ltd</publisher><subject>Allium - chemistry ; Allium vegetables ; Databases, Factual ; Diet ; Epidemiology ; Esophageal Neoplasms - epidemiology ; Gastrointestinal Neoplasms - epidemiology ; Head and Neck Neoplasms - epidemiology ; Humans ; Observational Studies as Topic ; Risk Factors ; Squamous cell carcinoma ; Upper aerodigestive tract cancer</subject><ispartof>Molecular nutrition & food research, 2016-01, Vol.60 (1), p.212-222</ispartof><rights>2015 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim</rights><rights>2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4487-e427281aea9a9feb3ab75b3e0684c0cf6f9384211a130fc62d4deb59df8a18e63</citedby><cites>FETCH-LOGICAL-c4487-e427281aea9a9feb3ab75b3e0684c0cf6f9384211a130fc62d4deb59df8a18e63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fmnfr.201500587$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fmnfr.201500587$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,27922,27923,45572,45573</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26464065$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Guercio, Valentina</creatorcontrib><creatorcontrib>Turati, Federica</creatorcontrib><creatorcontrib>La Vecchia, Carlo</creatorcontrib><creatorcontrib>Galeone, Carlotta</creatorcontrib><creatorcontrib>Tavani, Alessandra</creatorcontrib><title>Allium vegetables and upper aerodigestive tract cancers: a meta-analysis of observational studies</title><title>Molecular nutrition & food research</title><addtitle>Mol. Nutr. Food Res</addtitle><description>Scope
To provide updated quantitative overall estimations of the relation between total allium, garlic, and onion intake on the risk of cancer of the upper aerodigestive tract (UADT).
Methods and results
We combined data of published observational studies (21 case–control and four cohort studies), using a meta‐analytic approach and random effects models. The overall relative risks (RR) and 95% confidence intervals (CIs) for the squamous cell carcinoma of the UADT were 0.79 (95% CI 0.56–1.11) for total allium, 0.74 (95% CI 0.57–0.95) for garlic, and 0.72 (95% CI 0.57–0.91) for onion for the highest versus the lowest consumption. The inverse relation was apparently stronger in case–control studies (RR 0.56, 95% CI 0.38–0.83 for total allium), in Chinese studies (RR 0.67, 95% CI 0.45–0.98 for garlic intake), and for esophageal than for head and neck cancers. Apparently, there was no relation between allium vegetable intake and adenocarcinoma of the esophagus.
Conclusion
We found a moderate inverse association between allium vegetable intake and the risk of squamous cell carcinoma of the UADT in case–control studies. The relation was unclear in cohort studies and for adenocarcinoma of the esophagus.</description><subject>Allium - chemistry</subject><subject>Allium vegetables</subject><subject>Databases, Factual</subject><subject>Diet</subject><subject>Epidemiology</subject><subject>Esophageal Neoplasms - epidemiology</subject><subject>Gastrointestinal Neoplasms - epidemiology</subject><subject>Head and Neck Neoplasms - epidemiology</subject><subject>Humans</subject><subject>Observational Studies as Topic</subject><subject>Risk Factors</subject><subject>Squamous cell carcinoma</subject><subject>Upper aerodigestive tract cancer</subject><issn>1613-4125</issn><issn>1613-4133</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkElvFDEQRi0EIuuVI_KRSw_e280tCswEKQQJZTla1e5yZOhlsLsnmX-fHk2YK6cqld73qfQI-cDZgjMmPnd9SAvBuGZM2_INOeaGy0JxKd8edqGPyEnOvxmTXCj5nhwJo4xiRh8TuGjbOHV0g484Qt1iptA3dFqvMVHANDTxEfMYN0jHBH6kHnqPKX-hQLs5UUAP7TbHTIdAhzpj2sAYh_lI8zg1EfMZeRegzXj-Ok_J3fLb7eVVcf1z9f3y4rrwStmyQCVKYTkgVFAFrCXUpa4lMmOVZz6YUEmrBOfAJQveiEY1WOuqCRa4RSNPyad97zoNf6f5Z9fF7LFtocdhyo6XWjFrLNuhiz3q05BzwuDWKXaQto4zt9PqdlrdQesc-PjaPdUdNgf8n8cZUHvgKba4_U-d-3Gz_CU03_UW-1jMIz4fYpD-OFPKUruHm5Vbfb1fsluuXSVfAN9ZlBM</recordid><startdate>201601</startdate><enddate>201601</enddate><creator>Guercio, Valentina</creator><creator>Turati, Federica</creator><creator>La Vecchia, Carlo</creator><creator>Galeone, Carlotta</creator><creator>Tavani, Alessandra</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201601</creationdate><title>Allium vegetables and upper aerodigestive tract cancers: a meta-analysis of observational studies</title><author>Guercio, Valentina ; Turati, Federica ; La Vecchia, Carlo ; Galeone, Carlotta ; Tavani, Alessandra</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4487-e427281aea9a9feb3ab75b3e0684c0cf6f9384211a130fc62d4deb59df8a18e63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Allium - chemistry</topic><topic>Allium vegetables</topic><topic>Databases, Factual</topic><topic>Diet</topic><topic>Epidemiology</topic><topic>Esophageal Neoplasms - epidemiology</topic><topic>Gastrointestinal Neoplasms - epidemiology</topic><topic>Head and Neck Neoplasms - epidemiology</topic><topic>Humans</topic><topic>Observational Studies as Topic</topic><topic>Risk Factors</topic><topic>Squamous cell carcinoma</topic><topic>Upper aerodigestive tract cancer</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Guercio, Valentina</creatorcontrib><creatorcontrib>Turati, Federica</creatorcontrib><creatorcontrib>La Vecchia, Carlo</creatorcontrib><creatorcontrib>Galeone, Carlotta</creatorcontrib><creatorcontrib>Tavani, Alessandra</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Molecular nutrition & food research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Guercio, Valentina</au><au>Turati, Federica</au><au>La Vecchia, Carlo</au><au>Galeone, Carlotta</au><au>Tavani, Alessandra</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Allium vegetables and upper aerodigestive tract cancers: a meta-analysis of observational studies</atitle><jtitle>Molecular nutrition & food research</jtitle><addtitle>Mol. Nutr. Food Res</addtitle><date>2016-01</date><risdate>2016</risdate><volume>60</volume><issue>1</issue><spage>212</spage><epage>222</epage><pages>212-222</pages><issn>1613-4125</issn><eissn>1613-4133</eissn><abstract>Scope
To provide updated quantitative overall estimations of the relation between total allium, garlic, and onion intake on the risk of cancer of the upper aerodigestive tract (UADT).
Methods and results
We combined data of published observational studies (21 case–control and four cohort studies), using a meta‐analytic approach and random effects models. The overall relative risks (RR) and 95% confidence intervals (CIs) for the squamous cell carcinoma of the UADT were 0.79 (95% CI 0.56–1.11) for total allium, 0.74 (95% CI 0.57–0.95) for garlic, and 0.72 (95% CI 0.57–0.91) for onion for the highest versus the lowest consumption. The inverse relation was apparently stronger in case–control studies (RR 0.56, 95% CI 0.38–0.83 for total allium), in Chinese studies (RR 0.67, 95% CI 0.45–0.98 for garlic intake), and for esophageal than for head and neck cancers. Apparently, there was no relation between allium vegetable intake and adenocarcinoma of the esophagus.
Conclusion
We found a moderate inverse association between allium vegetable intake and the risk of squamous cell carcinoma of the UADT in case–control studies. The relation was unclear in cohort studies and for adenocarcinoma of the esophagus.</abstract><cop>Germany</cop><pub>Blackwell Publishing Ltd</pub><pmid>26464065</pmid><doi>10.1002/mnfr.201500587</doi><tpages>11</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1613-4125 |
| ispartof | Molecular nutrition & food research, 2016-01, Vol.60 (1), p.212-222 |
| issn | 1613-4125 1613-4133 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1754086806 |
| source | MEDLINE; Wiley Online Library All Journals |
| subjects | Allium - chemistry Allium vegetables Databases, Factual Diet Epidemiology Esophageal Neoplasms - epidemiology Gastrointestinal Neoplasms - epidemiology Head and Neck Neoplasms - epidemiology Humans Observational Studies as Topic Risk Factors Squamous cell carcinoma Upper aerodigestive tract cancer |
| title | Allium vegetables and upper aerodigestive tract cancers: a meta-analysis of observational studies |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-13T20%3A56%3A20IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Allium%20vegetables%20and%20upper%20aerodigestive%20tract%20cancers:%20a%20meta-analysis%20of%20observational%20studies&rft.jtitle=Molecular%20nutrition%20&%20food%20research&rft.au=Guercio,%20Valentina&rft.date=2016-01&rft.volume=60&rft.issue=1&rft.spage=212&rft.epage=222&rft.pages=212-222&rft.issn=1613-4125&rft.eissn=1613-4133&rft_id=info:doi/10.1002/mnfr.201500587&rft_dat=%3Cproquest_cross%3E1754086806%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1754086806&rft_id=info:pmid/26464065&rfr_iscdi=true |