Activation of NMDA receptors drives action potentials in superficial dorsal horn from neonatal rats

We have investigated the role of NMDA receptors in mediating synaptic transmission in spinal cord lamina II over the first 2 weeks of postnatal development. High intensity root stimulation evoked D-APV-sensitive slow synaptic activity in lamina II neurons that drove action potential firing. This NMD...

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Veröffentlicht in:	Neuroreport 2000-06, Vol.11 (8), p.1721-1727
Hauptverfasser:	Bardoni, Rita, Magherini, Pier Cosimo, MacDermott, Amy B
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials - physiology Animals Animals, Newborn - physiology Bicuculline - pharmacology Biological and medical sciences Central nervous system Central neurotransmission. Neuromudulation. Pathways and receptors Electric Stimulation - methods Excitatory Postsynaptic Potentials - drug effects Excitatory Postsynaptic Potentials - physiology Fundamental and applied biological sciences. Psychology GABA Antagonists - pharmacology Glycine Agents - pharmacology In Vitro Techniques Neural Inhibition - drug effects Neural Inhibition - physiology Patch-Clamp Techniques Rats Receptors, N-Methyl-D-Aspartate - physiology Spinal Cord - physiology Spinal Nerve Roots - physiology Strychnine - pharmacology Synapses - drug effects Synapses - physiology Vertebrates: nervous system and sense organs
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