Reproductive Toxicity of 1-Bromopropane, a Newly Introduced Alternative to Ozone Layer Depleting Solvents, in Male Rats

1-Bromopropane has been newly introduced as an alternative to ozone-depleting solvents. We aimed to clarify its dose-dependent reproductive toxicity in male rats. Thirty-six Wistar male rats were randomly divided into 4 groups of 9. The groups were exposed to 200, 400, or 800 ppm 1-bromopropane or o...

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Veröffentlicht in:	Toxicological sciences 2000-04, Vol.54 (2), p.416-423
Hauptverfasser:	Ichihara, Gaku, Yu, Xiaozhong, Kitoh, Junzoh, Asaeda, Nobuyuki, Kumazawa, Toshihiko, Iwai, Hisakazu, Shibata, Eiji, Yamada, Tetsuya, Wang, Hailan, Xie, Zhenlin, Maeda, Kei-ichiro, Tsukamura, Hiroko, Takeuchi, Yasuhiro
Format:	Artikel
Sprache:	eng
Schlagworte:	1-bromopropane Administration, Inhalation alternative to chlorofluorocarbons Animals banana-like head Biological and medical sciences Chemical and industrial products toxicology. Toxic occupational diseases Dose-Response Relationship, Drug Hydrocarbons, Brominated - administration & dosage Hydrocarbons, Brominated - toxicity Male Medical sciences Organ Size - drug effects propyl bromide Prostate - drug effects Prostate - pathology Rats Rats, Wistar Reproduction - drug effects reproductive toxicity retention of elongated spermatid seminal vesicle Sertoli cell Solvents - administration & dosage Solvents - toxicity Specific Pathogen-Free Organisms Sperm Count - drug effects Sperm Motility - drug effects Spermatozoa - drug effects Spermatozoa - pathology Spermatozoa - physiology spermiation failure spermiogenesis Testis - drug effects Testis - pathology testosterone Testosterone - blood Toxicology Various organic compounds
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