Evidence for zinc protection against 2,5-hexanedione toxicity by co-exposure of rats to zinc chloride
The protective role of zinc against the toxic effects of 2,5‐hexanedione (2,5‐HD), the main neurotoxic metabolite of n‐hexane, was investigated by studying the interference of zinc on the toxicokinetics of 2,5‐HD. Six groups of Wistar rats were exposed for 3 days to diets containing 2,5‐HD, zinc chl...
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| Veröffentlicht in: | Journal of applied toxicology 2000-05, Vol.20 (3), p.211-214 |
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| creator | Mateus, M. L. Santos, A. P. M. Dos Batoreu, M. C. |
| description | The protective role of zinc against the toxic effects of 2,5‐hexanedione (2,5‐HD), the main neurotoxic metabolite of n‐hexane, was investigated by studying the interference of zinc on the toxicokinetics of 2,5‐HD. Six groups of Wistar rats were exposed for 3 days to diets containing 2,5‐HD, zinc chloride and 2,5‐HD+zinc chloride.
The amounts of pyrroles and free and total 2,5‐HD in urine were determined using Ehrlichs's reagent and gas chromatography/flame ionization detection, respectively. The results show that after the first day of co‐exposure (ZnCl2+2,5‐HD) there was a significant decrease in the excretion of pyrroles and free 2,5‐HD in rats exposed to the chemical mixture when compared to the pyrroles and free 2,5‐HD excreted in rats exposed to 2,5‐HD alone. However, no significant decrease was observed in the urinary excretion of total 2,5‐HD (free 2,5‐HD + preformed 2,5‐HD). Suggestions are made about the role played by this metal ion in inhibiting pyrrole formation. Copyright © 2000 John Wiley & Sons, Ltd. |
| doi_str_mv | 10.1002/(SICI)1099-1263(200005/06)20:3<211::AID-JAT636>3.0.CO;2-O |
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The amounts of pyrroles and free and total 2,5‐HD in urine were determined using Ehrlichs's reagent and gas chromatography/flame ionization detection, respectively. The results show that after the first day of co‐exposure (ZnCl2+2,5‐HD) there was a significant decrease in the excretion of pyrroles and free 2,5‐HD in rats exposed to the chemical mixture when compared to the pyrroles and free 2,5‐HD excreted in rats exposed to 2,5‐HD alone. However, no significant decrease was observed in the urinary excretion of total 2,5‐HD (free 2,5‐HD + preformed 2,5‐HD). Suggestions are made about the role played by this metal ion in inhibiting pyrrole formation. Copyright © 2000 John Wiley & Sons, Ltd.</description><identifier>ISSN: 0260-437X</identifier><identifier>EISSN: 1099-1263</identifier><identifier>DOI: 10.1002/(SICI)1099-1263(200005/06)20:3<211::AID-JAT636>3.0.CO;2-O</identifier><identifier>PMID: 10797474</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>2,5-Hexanedione ; 5-hexanedione ; Animals ; Chlorides - therapeutic use ; excretion ; Hexanones - antagonists & inhibitors ; Hexanones - pharmacokinetics ; Hexanones - toxicity ; Male ; n-Hexane ; Neurotoxicity Syndromes - prevention & control ; pyrroles ; Pyrroles - urine ; Rats ; Rats, Wistar ; Spectrophotometry, Atomic ; urine ; zinc ; zinc chloride ; Zinc Compounds - therapeutic use</subject><ispartof>Journal of applied toxicology, 2000-05, Vol.20 (3), p.211-214</ispartof><rights>Copyright © 2000 John Wiley & Sons, Ltd.</rights><rights>Copyright 2000 John Wiley & Sons, Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c4056-7d5793dd7d10efbb421a260f9ff0edc75829825c5e854edb605d013f37ae83993</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2F%28SICI%291099-1263%28200005%2F06%2920%3A3%3C211%3A%3AAID-JAT636%3E3.0.CO%3B2-O$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2F%28SICI%291099-1263%28200005%2F06%2920%3A3%3C211%3A%3AAID-JAT636%3E3.0.CO%3B2-O$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10797474$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mateus, M. L.</creatorcontrib><creatorcontrib>Santos, A. P. M. Dos</creatorcontrib><creatorcontrib>Batoreu, M. C.</creatorcontrib><title>Evidence for zinc protection against 2,5-hexanedione toxicity by co-exposure of rats to zinc chloride</title><title>Journal of applied toxicology</title><addtitle>J. Appl. Toxicol</addtitle><description>The protective role of zinc against the toxic effects of 2,5‐hexanedione (2,5‐HD), the main neurotoxic metabolite of n‐hexane, was investigated by studying the interference of zinc on the toxicokinetics of 2,5‐HD. Six groups of Wistar rats were exposed for 3 days to diets containing 2,5‐HD, zinc chloride and 2,5‐HD+zinc chloride.
The amounts of pyrroles and free and total 2,5‐HD in urine were determined using Ehrlichs's reagent and gas chromatography/flame ionization detection, respectively. The results show that after the first day of co‐exposure (ZnCl2+2,5‐HD) there was a significant decrease in the excretion of pyrroles and free 2,5‐HD in rats exposed to the chemical mixture when compared to the pyrroles and free 2,5‐HD excreted in rats exposed to 2,5‐HD alone. However, no significant decrease was observed in the urinary excretion of total 2,5‐HD (free 2,5‐HD + preformed 2,5‐HD). Suggestions are made about the role played by this metal ion in inhibiting pyrrole formation. Copyright © 2000 John Wiley & Sons, Ltd.</description><subject>2,5-Hexanedione</subject><subject>5-hexanedione</subject><subject>Animals</subject><subject>Chlorides - therapeutic use</subject><subject>excretion</subject><subject>Hexanones - antagonists & inhibitors</subject><subject>Hexanones - pharmacokinetics</subject><subject>Hexanones - toxicity</subject><subject>Male</subject><subject>n-Hexane</subject><subject>Neurotoxicity Syndromes - prevention & control</subject><subject>pyrroles</subject><subject>Pyrroles - urine</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Spectrophotometry, Atomic</subject><subject>urine</subject><subject>zinc</subject><subject>zinc chloride</subject><subject>Zinc Compounds - therapeutic use</subject><issn>0260-437X</issn><issn>1099-1263</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkV1v0zAUhiMEYmXwF1Cu0CaRzh-xnXQIqQpjFE0EiaENuDhKnBNmSONip9Dy63GVakICab6xffz6OR9vFM0pmVJC2MnRh0WxOKYkzxPKJD9iJCxxQuQxIzP-glE6m80Xr5K380vJ5Us-JdOiPGVJeS-a3P66H00IkyRJubo-iB55_y1A8pxlD6MDSlSuUpVOIjz7aRrsNcatdfFv0-t45eyAejC2j6uvlen9ELPnIrnBTdVjE8IYD3ZjtBm2cb2NtU1ws7J-7TC2beyqwYf3EaVvOusC_3H0oK06j0_2-2H08fXZZfEmuSjPF8X8ItEpETJRjVA5bxrVUIJtXaeMVqGFNm9bgo1WImN5xoQWmIkUm1oS0RDKW64qzHie88Po2cgNPfxYox9gabzGrguV27UHqgSXmaR3C1ORcsZIEH4ahdpZ7x22sHJmWbktUAI7swB2ZsFu7LAbO4xmAZHhBOFKKUAwC0azQoRAUQKDMrCf7otY10ts_iKP7gTBl1Hwy3S4_Sfz3Yn_m3cfCfRkpBs_4OaWXrnvIBVXAq7enYN4z7PPV9cCBP8DVkTAAQ</recordid><startdate>200005</startdate><enddate>200005</enddate><creator>Mateus, M. L.</creator><creator>Santos, A. P. M. Dos</creator><creator>Batoreu, M. C.</creator><general>John Wiley & Sons, Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7ST</scope><scope>C1K</scope><scope>SOI</scope><scope>7U7</scope></search><sort><creationdate>200005</creationdate><title>Evidence for zinc protection against 2,5-hexanedione toxicity by co-exposure of rats to zinc chloride</title><author>Mateus, M. L. ; Santos, A. P. M. Dos ; Batoreu, M. C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4056-7d5793dd7d10efbb421a260f9ff0edc75829825c5e854edb605d013f37ae83993</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>2,5-Hexanedione</topic><topic>5-hexanedione</topic><topic>Animals</topic><topic>Chlorides - therapeutic use</topic><topic>excretion</topic><topic>Hexanones - antagonists & inhibitors</topic><topic>Hexanones - pharmacokinetics</topic><topic>Hexanones - toxicity</topic><topic>Male</topic><topic>n-Hexane</topic><topic>Neurotoxicity Syndromes - prevention & control</topic><topic>pyrroles</topic><topic>Pyrroles - urine</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Spectrophotometry, Atomic</topic><topic>urine</topic><topic>zinc</topic><topic>zinc chloride</topic><topic>Zinc Compounds - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mateus, M. L.</creatorcontrib><creatorcontrib>Santos, A. P. M. Dos</creatorcontrib><creatorcontrib>Batoreu, M. C.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Environment Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Environment Abstracts</collection><collection>Toxicology Abstracts</collection><jtitle>Journal of applied toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mateus, M. L.</au><au>Santos, A. P. M. Dos</au><au>Batoreu, M. C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evidence for zinc protection against 2,5-hexanedione toxicity by co-exposure of rats to zinc chloride</atitle><jtitle>Journal of applied toxicology</jtitle><addtitle>J. Appl. Toxicol</addtitle><date>2000-05</date><risdate>2000</risdate><volume>20</volume><issue>3</issue><spage>211</spage><epage>214</epage><pages>211-214</pages><issn>0260-437X</issn><eissn>1099-1263</eissn><abstract>The protective role of zinc against the toxic effects of 2,5‐hexanedione (2,5‐HD), the main neurotoxic metabolite of n‐hexane, was investigated by studying the interference of zinc on the toxicokinetics of 2,5‐HD. Six groups of Wistar rats were exposed for 3 days to diets containing 2,5‐HD, zinc chloride and 2,5‐HD+zinc chloride.
The amounts of pyrroles and free and total 2,5‐HD in urine were determined using Ehrlichs's reagent and gas chromatography/flame ionization detection, respectively. The results show that after the first day of co‐exposure (ZnCl2+2,5‐HD) there was a significant decrease in the excretion of pyrroles and free 2,5‐HD in rats exposed to the chemical mixture when compared to the pyrroles and free 2,5‐HD excreted in rats exposed to 2,5‐HD alone. However, no significant decrease was observed in the urinary excretion of total 2,5‐HD (free 2,5‐HD + preformed 2,5‐HD). Suggestions are made about the role played by this metal ion in inhibiting pyrrole formation. Copyright © 2000 John Wiley & Sons, Ltd.</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>10797474</pmid><doi>10.1002/(SICI)1099-1263(200005/06)20:3<211::AID-JAT636>3.0.CO;2-O</doi><tpages>4</tpages></addata></record> |
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| subjects | 2,5-Hexanedione 5-hexanedione Animals Chlorides - therapeutic use excretion Hexanones - antagonists & inhibitors Hexanones - pharmacokinetics Hexanones - toxicity Male n-Hexane Neurotoxicity Syndromes - prevention & control pyrroles Pyrroles - urine Rats Rats, Wistar Spectrophotometry, Atomic urine zinc zinc chloride Zinc Compounds - therapeutic use |
| title | Evidence for zinc protection against 2,5-hexanedione toxicity by co-exposure of rats to zinc chloride |
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