Effect of vitamin E on lipid peroxidation and liver monooxygenase activity in experimental influenza virus infection
Influenza virus infection was associated with development of oxidative stress in liver of mice, viz. increase in amount of lipid peroxidation products, decrease in cytochrome P-450 and NADP.H-cytochrome c-reductase activity, and inhibition of liver monooxygenases (aniline hydroxylase, ethylmorphine-...
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| Veröffentlicht in: | Toxicology letters 2000-04, Vol.114 (1-3), p.39-45 |
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| container_end_page | 45 |
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| container_issue | 1-3 |
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| container_title | Toxicology letters |
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| creator | MILEVA, M TANCHEVA, L BAKALOVA, R GALABOV, A SAVOV, V RIBAROV, S |
| description | Influenza virus infection was associated with development of oxidative stress in liver of mice, viz. increase in amount of lipid peroxidation products, decrease in cytochrome P-450 and NADP.H-cytochrome c-reductase activity, and inhibition of liver monooxygenases (aniline hydroxylase, ethylmorphine-N-demethylase, amidopyrine-N-demethylase and analgin-N-demethylase). These effects were most pronounced on the 7th day after virus inoculation as compared to the 5th one. Supplementation of mice with vitamin E before virus inoculation leads to liver protection against oxidative stress and toxicosis. A marked decrease of lipid peroxidation products and an increase of cytochrome P-450 and activities of monooxygenases was established. The stabilizing effect of vitamin E was dose-dependent and was most pronounced on the 5th day after virus inoculation as compared to the 7th one. |
| doi_str_mv | 10.1016/S0378-4274(99)00265-9 |
| format | Article |
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These effects were most pronounced on the 7th day after virus inoculation as compared to the 5th one. Supplementation of mice with vitamin E before virus inoculation leads to liver protection against oxidative stress and toxicosis. A marked decrease of lipid peroxidation products and an increase of cytochrome P-450 and activities of monooxygenases was established. The stabilizing effect of vitamin E was dose-dependent and was most pronounced on the 5th day after virus inoculation as compared to the 7th one.</description><identifier>ISSN: 0378-4274</identifier><identifier>EISSN: 1879-3169</identifier><identifier>DOI: 10.1016/S0378-4274(99)00265-9</identifier><identifier>CODEN: TOLED5</identifier><language>eng</language><publisher>Shannon: Elsevier Science</publisher><subject>a-Tocopherol ; Biological and medical sciences ; Experimental viral diseases and models ; Infectious diseases ; Influenza virus ; Medical sciences ; monooxygenase ; monooxygenases ; Viral diseases</subject><ispartof>Toxicology letters, 2000-04, Vol.114 (1-3), p.39-45</ispartof><rights>2000 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1321445$$DView record in Pascal Francis$$Hfree_for_read</backlink></links><search><creatorcontrib>MILEVA, M</creatorcontrib><creatorcontrib>TANCHEVA, L</creatorcontrib><creatorcontrib>BAKALOVA, R</creatorcontrib><creatorcontrib>GALABOV, A</creatorcontrib><creatorcontrib>SAVOV, V</creatorcontrib><creatorcontrib>RIBAROV, S</creatorcontrib><title>Effect of vitamin E on lipid peroxidation and liver monooxygenase activity in experimental influenza virus infection</title><title>Toxicology letters</title><description>Influenza virus infection was associated with development of oxidative stress in liver of mice, viz. increase in amount of lipid peroxidation products, decrease in cytochrome P-450 and NADP.H-cytochrome c-reductase activity, and inhibition of liver monooxygenases (aniline hydroxylase, ethylmorphine-N-demethylase, amidopyrine-N-demethylase and analgin-N-demethylase). These effects were most pronounced on the 7th day after virus inoculation as compared to the 5th one. Supplementation of mice with vitamin E before virus inoculation leads to liver protection against oxidative stress and toxicosis. A marked decrease of lipid peroxidation products and an increase of cytochrome P-450 and activities of monooxygenases was established. The stabilizing effect of vitamin E was dose-dependent and was most pronounced on the 5th day after virus inoculation as compared to the 7th one.</description><subject>a-Tocopherol</subject><subject>Biological and medical sciences</subject><subject>Experimental viral diseases and models</subject><subject>Infectious diseases</subject><subject>Influenza virus</subject><subject>Medical sciences</subject><subject>monooxygenase</subject><subject>monooxygenases</subject><subject>Viral diseases</subject><issn>0378-4274</issn><issn>1879-3169</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><recordid>eNo9j0tLxDAUhYMoOI7-BCELEV1U82raLEXGBwy4UNflNk0k0ia1SYcZf70RB1eXc_jOuRyEzim5oYTK21fCq7oQrBJXSl0TwmRZqAO0oHWlCk6lOkSLf-QYncT4SQiRQpYLlFbWGp1wsHjjEgzO4xUOHvdudB0ezRS2roPksgW-y_bGTHgIPoTt7sN4iAaDTi5ndzhnzTZH3GB8gj5r28_Gf0Ounub4q_OrXHWKjiz00Zzt7xK9P6ze7p-K9cvj8_3duhipKFOhK14rYbpWys4yS9uKUNDQ2pozrsC2ivCaktpyAFYS05aaWkIE66o81Gq-RJd_veMUvmYTUzO4qE3fgzdhjg2tSi4llxm82IMQNfR2Aq9dbMY8BaZdQzmjQpT8ByVJbwI</recordid><startdate>20000403</startdate><enddate>20000403</enddate><creator>MILEVA, M</creator><creator>TANCHEVA, L</creator><creator>BAKALOVA, R</creator><creator>GALABOV, A</creator><creator>SAVOV, V</creator><creator>RIBAROV, S</creator><general>Elsevier Science</general><scope>IQODW</scope><scope>7U7</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope></search><sort><creationdate>20000403</creationdate><title>Effect of vitamin E on lipid peroxidation and liver monooxygenase activity in experimental influenza virus infection</title><author>MILEVA, M ; TANCHEVA, L ; BAKALOVA, R ; GALABOV, A ; SAVOV, V ; RIBAROV, S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p145t-c73894edb66df2f1b701acabf83239afb9038108f3aa250eb5c1f0042d7274fc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>a-Tocopherol</topic><topic>Biological and medical sciences</topic><topic>Experimental viral diseases and models</topic><topic>Infectious diseases</topic><topic>Influenza virus</topic><topic>Medical sciences</topic><topic>monooxygenase</topic><topic>monooxygenases</topic><topic>Viral diseases</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MILEVA, M</creatorcontrib><creatorcontrib>TANCHEVA, L</creatorcontrib><creatorcontrib>BAKALOVA, R</creatorcontrib><creatorcontrib>GALABOV, A</creatorcontrib><creatorcontrib>SAVOV, V</creatorcontrib><creatorcontrib>RIBAROV, S</creatorcontrib><collection>Pascal-Francis</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Toxicology letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MILEVA, M</au><au>TANCHEVA, L</au><au>BAKALOVA, R</au><au>GALABOV, A</au><au>SAVOV, V</au><au>RIBAROV, S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of vitamin E on lipid peroxidation and liver monooxygenase activity in experimental influenza virus infection</atitle><jtitle>Toxicology letters</jtitle><date>2000-04-03</date><risdate>2000</risdate><volume>114</volume><issue>1-3</issue><spage>39</spage><epage>45</epage><pages>39-45</pages><issn>0378-4274</issn><eissn>1879-3169</eissn><coden>TOLED5</coden><abstract>Influenza virus infection was associated with development of oxidative stress in liver of mice, viz. increase in amount of lipid peroxidation products, decrease in cytochrome P-450 and NADP.H-cytochrome c-reductase activity, and inhibition of liver monooxygenases (aniline hydroxylase, ethylmorphine-N-demethylase, amidopyrine-N-demethylase and analgin-N-demethylase). These effects were most pronounced on the 7th day after virus inoculation as compared to the 5th one. Supplementation of mice with vitamin E before virus inoculation leads to liver protection against oxidative stress and toxicosis. A marked decrease of lipid peroxidation products and an increase of cytochrome P-450 and activities of monooxygenases was established. The stabilizing effect of vitamin E was dose-dependent and was most pronounced on the 5th day after virus inoculation as compared to the 7th one.</abstract><cop>Shannon</cop><cop>Amsterdam</cop><pub>Elsevier Science</pub><doi>10.1016/S0378-4274(99)00265-9</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Toxicology letters, 2000-04, Vol.114 (1-3), p.39-45 |
| issn | 0378-4274 1879-3169 |
| language | eng |
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| source | ScienceDirect Journals (5 years ago - present) |
| subjects | a-Tocopherol Biological and medical sciences Experimental viral diseases and models Infectious diseases Influenza virus Medical sciences monooxygenase monooxygenases Viral diseases |
| title | Effect of vitamin E on lipid peroxidation and liver monooxygenase activity in experimental influenza virus infection |
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