Importance of the Sgs1 helicase activity in DNA repair of Saccharomyces cerevisiae

The Saccharomyces cerevisiae Sgs1 protein, together with Schizosaccharomyces pombe Rqh1 and the human Bloom and Werner proteins, is a DNA helicase of the Escherichia coli RecQ family. Mutation of SGS1 causes premature aging in yeast cells, including the accumulation of extrachromosomal rDNA circles....

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Veröffentlicht in:	Current genetics 2000-02, Vol.37 (2), p.75-78
Hauptverfasser:	Saffi, J, Pereira, V.R, Henriques, J.A.P
Format:	Artikel
Sprache:	eng
Schlagworte:	4-Nitroquinoline-1-oxide - pharmacology Cell Division - drug effects Cell Division - genetics Cell Division - radiation effects DNA Helicases - genetics DNA Helicases - metabolism DNA Repair DNA-binding proteins enzyme activity enzymes epistasis hydrogen peroxide Hydrogen Peroxide - pharmacology hydroxycarbamide hydroxyurea Hydroxyurea - pharmacology interactions Mechlorethamine - pharmacology methyl methanesulfonate Methyl Methanesulfonate - pharmacology mutagenicity Mutagens - pharmacology mutants Mutation Quinolones - pharmacology Rad16 protein RecQ Helicases rRNA Saccharomyces cerevisiae Saccharomyces cerevisiae - drug effects Saccharomyces cerevisiae - enzymology Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae Proteins SGS1 gene Sgs1 protein ultraviolet radiation Ultraviolet Rays
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