Induction of Stem-Cell-Derived Functional Neurons by NanoScript-Based Gene Repression

Even though gene repression is a powerful approach to exogenously regulate cellular behavior, developing a platform to effectively repress targeted genes, especially for stem‐cell applications, remains elusive. Herein, we introduce a nanomaterial‐based platform that is capable of mimicking the funct...

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Veröffentlicht in:	Angewandte Chemie International Edition 2015-10, Vol.54 (41), p.11983-11988
Hauptverfasser:	Patel, Sahishnu, Chueng, Sy-Tsong Dean, Yin, Perry T., Dardir, Kholud, Song, Zhichao, Pasquale, Nicholas, Kwan, Kelvin, Sugiyama, Hiroshi, Lee, Ki-Bum
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomimetic Materials - chemistry Biomimetic Materials - metabolism Biomimetics - methods Differentiation Gene Expression gene knockdown Gene Knockdown Techniques - methods Genes Green Fluorescent Proteins - genetics Humans Knock nanoparticles Nanoparticles - chemistry Nanoparticles - metabolism NanoScript Nanostructure Neural Stem Cells - cytology Neural Stem Cells - metabolism Neurogenesis neuronal differentiation Neurons Neurons - cytology Neurons - metabolism Nylons - chemistry Nylons - metabolism Platforms Promoter Regions, Genetic Repressor Proteins - chemistry Repressor Proteins - metabolism SOX9 Transcription Factor - genetics Stem cells transcription repressor proteins
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