Application of the pulsed light technology to mycotoxin degradation and inactivation
ABSTRACT The persistence of mycotoxins and their metabolites in agricultural products is a major safety concern because of their high resistance to all kinds of decontamination techniques. In this study, we evaluated the effectiveness of the pulsed light technology for the degradation of mycotoxins....
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| Veröffentlicht in: | Journal of applied toxicology 2013-05, Vol.33 (5), p.357-363 |
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| creator | Moreau, Morgane Lescure, Geoffroy Agoulon, Adrien Svinareff, Pascal Orange, Nicole Feuilloley, Marc |
| description | ABSTRACT
The persistence of mycotoxins and their metabolites in agricultural products is a major safety concern because of their high resistance to all kinds of decontamination techniques. In this study, we evaluated the effectiveness of the pulsed light technology for the degradation of mycotoxins. We report that eight flashes of pulsed light destroyed of 84.5 ± 1.9, 72.5 ± 1.1, 92.7 ± 0.8 and 98.1 ± 0.2% of zearalenone, deoxynivalenol, aflatoxin B1 and ochratoxin in solution. The degradation of the molecules was monitored by HPLC and LC‐MS/MS analysis. We estimated the potential toxicity of zearalenone and deoxynivelenol after exposure to a pulsed light treatment using the Caenorhabditis elegans survival tests. The genotoxicity of aflatoxin B1 was also investigated using a complete Ames test. The results show that the treatment of zearalenone and deoxynivelenol by single or multiple flashes of pulsed light is associated with a stagnation or marginal decrease of the toxicity of the mycotoxins and that treatment of aflatoxin B1 by pulsed light can completely eliminate the mutagenic potential of this mycotoxin. This work provides the first demonstration of a nonthermal technology allowing mycotoxin destruction and inactivation of their mutagenic activity. Copyright © 2011 John Wiley & Sons, Ltd.
Pulsed light technology is an efficient tool for mycotoxin inactivation. This paper shows that the fragmentation of four mycotoxins is rapidly observed after a short number of pulses of light and that the toxicity of some mycotoxins can be inhibited. Moreover the mutagenic potential of aflatoxin B1 seems to be abolished by this technique. |
| doi_str_mv | 10.1002/jat.1749 |
| format | Article |
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The persistence of mycotoxins and their metabolites in agricultural products is a major safety concern because of their high resistance to all kinds of decontamination techniques. In this study, we evaluated the effectiveness of the pulsed light technology for the degradation of mycotoxins. We report that eight flashes of pulsed light destroyed of 84.5 ± 1.9, 72.5 ± 1.1, 92.7 ± 0.8 and 98.1 ± 0.2% of zearalenone, deoxynivalenol, aflatoxin B1 and ochratoxin in solution. The degradation of the molecules was monitored by HPLC and LC‐MS/MS analysis. We estimated the potential toxicity of zearalenone and deoxynivelenol after exposure to a pulsed light treatment using the Caenorhabditis elegans survival tests. The genotoxicity of aflatoxin B1 was also investigated using a complete Ames test. The results show that the treatment of zearalenone and deoxynivelenol by single or multiple flashes of pulsed light is associated with a stagnation or marginal decrease of the toxicity of the mycotoxins and that treatment of aflatoxin B1 by pulsed light can completely eliminate the mutagenic potential of this mycotoxin. This work provides the first demonstration of a nonthermal technology allowing mycotoxin destruction and inactivation of their mutagenic activity. Copyright © 2011 John Wiley & Sons, Ltd.
Pulsed light technology is an efficient tool for mycotoxin inactivation. This paper shows that the fragmentation of four mycotoxins is rapidly observed after a short number of pulses of light and that the toxicity of some mycotoxins can be inhibited. Moreover the mutagenic potential of aflatoxin B1 seems to be abolished by this technique.</description><identifier>ISSN: 0260-437X</identifier><identifier>EISSN: 1099-1263</identifier><identifier>DOI: 10.1002/jat.1749</identifier><identifier>PMID: 22025267</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>Aflatoxin B1 - chemistry ; Aflatoxin B1 - radiation effects ; Aflatoxins ; Biodegradation ; Caenorhabditis elegans ; Chromatography, High Pressure Liquid ; Chromatography, Liquid ; cytotoxicity ; Degradation ; Inactivation ; Metabolites ; mutagenicity ; Mycotoxins ; Ochratoxins - chemistry ; Ochratoxins - radiation effects ; pulsed light ; Reproduction ; Tandem Mass Spectrometry ; Technology ; Toxicity ; Toxins ; Trichothecenes - chemistry ; Trichothecenes - radiation effects ; Zearalenone ; Zearalenone - chemistry ; Zearalenone - radiation effects</subject><ispartof>Journal of applied toxicology, 2013-05, Vol.33 (5), p.357-363</ispartof><rights>Copyright © 2011 John Wiley & Sons, Ltd.</rights><rights>Copyright © 2013 John Wiley & Sons, Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4869-7f4dc25c575572f159beb9cf555e8bc1b5c94c174e874f671fa60cea22e22fbc3</citedby><cites>FETCH-LOGICAL-c4869-7f4dc25c575572f159beb9cf555e8bc1b5c94c174e874f671fa60cea22e22fbc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjat.1749$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjat.1749$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22025267$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Moreau, Morgane</creatorcontrib><creatorcontrib>Lescure, Geoffroy</creatorcontrib><creatorcontrib>Agoulon, Adrien</creatorcontrib><creatorcontrib>Svinareff, Pascal</creatorcontrib><creatorcontrib>Orange, Nicole</creatorcontrib><creatorcontrib>Feuilloley, Marc</creatorcontrib><title>Application of the pulsed light technology to mycotoxin degradation and inactivation</title><title>Journal of applied toxicology</title><addtitle>J. Appl. Toxicol</addtitle><description>ABSTRACT
The persistence of mycotoxins and their metabolites in agricultural products is a major safety concern because of their high resistance to all kinds of decontamination techniques. In this study, we evaluated the effectiveness of the pulsed light technology for the degradation of mycotoxins. We report that eight flashes of pulsed light destroyed of 84.5 ± 1.9, 72.5 ± 1.1, 92.7 ± 0.8 and 98.1 ± 0.2% of zearalenone, deoxynivalenol, aflatoxin B1 and ochratoxin in solution. The degradation of the molecules was monitored by HPLC and LC‐MS/MS analysis. We estimated the potential toxicity of zearalenone and deoxynivelenol after exposure to a pulsed light treatment using the Caenorhabditis elegans survival tests. The genotoxicity of aflatoxin B1 was also investigated using a complete Ames test. The results show that the treatment of zearalenone and deoxynivelenol by single or multiple flashes of pulsed light is associated with a stagnation or marginal decrease of the toxicity of the mycotoxins and that treatment of aflatoxin B1 by pulsed light can completely eliminate the mutagenic potential of this mycotoxin. This work provides the first demonstration of a nonthermal technology allowing mycotoxin destruction and inactivation of their mutagenic activity. Copyright © 2011 John Wiley & Sons, Ltd.
Pulsed light technology is an efficient tool for mycotoxin inactivation. This paper shows that the fragmentation of four mycotoxins is rapidly observed after a short number of pulses of light and that the toxicity of some mycotoxins can be inhibited. Moreover the mutagenic potential of aflatoxin B1 seems to be abolished by this technique.</description><subject>Aflatoxin B1 - chemistry</subject><subject>Aflatoxin B1 - radiation effects</subject><subject>Aflatoxins</subject><subject>Biodegradation</subject><subject>Caenorhabditis elegans</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Chromatography, Liquid</subject><subject>cytotoxicity</subject><subject>Degradation</subject><subject>Inactivation</subject><subject>Metabolites</subject><subject>mutagenicity</subject><subject>Mycotoxins</subject><subject>Ochratoxins - chemistry</subject><subject>Ochratoxins - radiation effects</subject><subject>pulsed light</subject><subject>Reproduction</subject><subject>Tandem Mass Spectrometry</subject><subject>Technology</subject><subject>Toxicity</subject><subject>Toxins</subject><subject>Trichothecenes - chemistry</subject><subject>Trichothecenes - radiation effects</subject><subject>Zearalenone</subject><subject>Zearalenone - chemistry</subject><subject>Zearalenone - radiation effects</subject><issn>0260-437X</issn><issn>1099-1263</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkVFrFDEQx4Mo9loFP4EEfPFlazKbbDaPR9FqWyvKiX0L2Wxyl3Nvs26ytvftzXlnC4I4LwMzv_nB8EfoBSWnlBB4s9bplAomH6EZJVIWFKryMZoRqEjBSnFzhI5jXBOSd1A_RUcABDhUYoYW82HovNHJhx4Hh9PK4mHqom1x55erhJM1qz50YbnFKeDN1oQU7nyPW7scdbu_032Lfa9N8j9_D56hJ05nx_NDP0Ff371dnL0vrj6dfzibXxWG1ZUshGOtAW644FyAo1w2tpHGcc5t3RjacCOZyX_ZWjBXCep0RYzVABbANaY8Qa_33mEMPyYbk9r4aGzX6d6GKSoqeMlLUVH4P8pKCbmkzOirv9B1mMY-P7KjWF3XUrAHoRlDjKN1ahj9Ro9bRYnahaJyKGoXSkZfHoRTs7HtPfgnhQwUe-DWd3b7T5G6mC8OwgPvY7J397wev6tsE1x9uz5X9Q18hi-XHxUtfwHPYKSc</recordid><startdate>201305</startdate><enddate>201305</enddate><creator>Moreau, Morgane</creator><creator>Lescure, Geoffroy</creator><creator>Agoulon, Adrien</creator><creator>Svinareff, Pascal</creator><creator>Orange, Nicole</creator><creator>Feuilloley, Marc</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7ST</scope><scope>7TK</scope><scope>7U7</scope><scope>C1K</scope><scope>K9.</scope><scope>SOI</scope><scope>8FD</scope><scope>FR3</scope><scope>KR7</scope></search><sort><creationdate>201305</creationdate><title>Application of the pulsed light technology to mycotoxin degradation and inactivation</title><author>Moreau, Morgane ; Lescure, Geoffroy ; Agoulon, Adrien ; Svinareff, Pascal ; Orange, Nicole ; Feuilloley, Marc</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4869-7f4dc25c575572f159beb9cf555e8bc1b5c94c174e874f671fa60cea22e22fbc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Aflatoxin B1 - chemistry</topic><topic>Aflatoxin B1 - radiation effects</topic><topic>Aflatoxins</topic><topic>Biodegradation</topic><topic>Caenorhabditis elegans</topic><topic>Chromatography, High Pressure Liquid</topic><topic>Chromatography, Liquid</topic><topic>cytotoxicity</topic><topic>Degradation</topic><topic>Inactivation</topic><topic>Metabolites</topic><topic>mutagenicity</topic><topic>Mycotoxins</topic><topic>Ochratoxins - chemistry</topic><topic>Ochratoxins - radiation effects</topic><topic>pulsed light</topic><topic>Reproduction</topic><topic>Tandem Mass Spectrometry</topic><topic>Technology</topic><topic>Toxicity</topic><topic>Toxins</topic><topic>Trichothecenes - chemistry</topic><topic>Trichothecenes - radiation effects</topic><topic>Zearalenone</topic><topic>Zearalenone - chemistry</topic><topic>Zearalenone - radiation effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Moreau, Morgane</creatorcontrib><creatorcontrib>Lescure, Geoffroy</creatorcontrib><creatorcontrib>Agoulon, Adrien</creatorcontrib><creatorcontrib>Svinareff, Pascal</creatorcontrib><creatorcontrib>Orange, Nicole</creatorcontrib><creatorcontrib>Feuilloley, Marc</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Environment Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Environment Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Civil Engineering Abstracts</collection><jtitle>Journal of applied toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Moreau, Morgane</au><au>Lescure, Geoffroy</au><au>Agoulon, Adrien</au><au>Svinareff, Pascal</au><au>Orange, Nicole</au><au>Feuilloley, Marc</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Application of the pulsed light technology to mycotoxin degradation and inactivation</atitle><jtitle>Journal of applied toxicology</jtitle><addtitle>J. Appl. Toxicol</addtitle><date>2013-05</date><risdate>2013</risdate><volume>33</volume><issue>5</issue><spage>357</spage><epage>363</epage><pages>357-363</pages><issn>0260-437X</issn><eissn>1099-1263</eissn><abstract>ABSTRACT
The persistence of mycotoxins and their metabolites in agricultural products is a major safety concern because of their high resistance to all kinds of decontamination techniques. In this study, we evaluated the effectiveness of the pulsed light technology for the degradation of mycotoxins. We report that eight flashes of pulsed light destroyed of 84.5 ± 1.9, 72.5 ± 1.1, 92.7 ± 0.8 and 98.1 ± 0.2% of zearalenone, deoxynivalenol, aflatoxin B1 and ochratoxin in solution. The degradation of the molecules was monitored by HPLC and LC‐MS/MS analysis. We estimated the potential toxicity of zearalenone and deoxynivelenol after exposure to a pulsed light treatment using the Caenorhabditis elegans survival tests. The genotoxicity of aflatoxin B1 was also investigated using a complete Ames test. The results show that the treatment of zearalenone and deoxynivelenol by single or multiple flashes of pulsed light is associated with a stagnation or marginal decrease of the toxicity of the mycotoxins and that treatment of aflatoxin B1 by pulsed light can completely eliminate the mutagenic potential of this mycotoxin. This work provides the first demonstration of a nonthermal technology allowing mycotoxin destruction and inactivation of their mutagenic activity. Copyright © 2011 John Wiley & Sons, Ltd.
Pulsed light technology is an efficient tool for mycotoxin inactivation. This paper shows that the fragmentation of four mycotoxins is rapidly observed after a short number of pulses of light and that the toxicity of some mycotoxins can be inhibited. Moreover the mutagenic potential of aflatoxin B1 seems to be abolished by this technique.</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>22025267</pmid><doi>10.1002/jat.1749</doi><tpages>7</tpages></addata></record> |
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| ispartof | Journal of applied toxicology, 2013-05, Vol.33 (5), p.357-363 |
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| subjects | Aflatoxin B1 - chemistry Aflatoxin B1 - radiation effects Aflatoxins Biodegradation Caenorhabditis elegans Chromatography, High Pressure Liquid Chromatography, Liquid cytotoxicity Degradation Inactivation Metabolites mutagenicity Mycotoxins Ochratoxins - chemistry Ochratoxins - radiation effects pulsed light Reproduction Tandem Mass Spectrometry Technology Toxicity Toxins Trichothecenes - chemistry Trichothecenes - radiation effects Zearalenone Zearalenone - chemistry Zearalenone - radiation effects |
| title | Application of the pulsed light technology to mycotoxin degradation and inactivation |
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