Acute toxic effects and gender-related biokinetics of silver nanoparticles following an intravenous injection in mice

ABSTRACT This study evaluated the acute toxicity and biokinetics of intravenously administered silver nanoparticles (AgNPs) in mice. Mice were exposed to different dosages of AgNPs (7.5, 30 or 120 mg kg−1). Toxic effects were assessed via general behavior, serum biochemical parameters and histopatho...

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Veröffentlicht in:	Journal of applied toxicology 2012-11, Vol.32 (11), p.890-899
Hauptverfasser:	Xue, Yuying, Zhang, Shanshan, Huang, Yanmei, Zhang, Ting, Liu, Xiaorun, Hu, Yuanyuan, Zhang, Zhiyong, Tang, Meng
Format:	Artikel
Sprache:	eng
Schlagworte:	acute toxic effects Animals Biological and medical sciences Chemical and industrial products toxicology. Toxic occupational diseases Dose-Response Relationship, Drug Female gender-related biokinetics Injections, Intravenous Kinetics Liver Male Mass Spectrometry Medical sciences Metal Nanoparticles - administration & dosage Metal Nanoparticles - toxicity Metals and various inorganic compounds Mice Mice, Inbred ICR Nanoparticles Nanoparticles - administration & dosage Nanoparticles - toxicity Rodents Sex Factors Silver Silver - administration & dosage Silver - metabolism Silver - toxicity silver nanoparticles Spleen Tissue Distribution Toxic Toxicity Toxicology
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