Structure of AAV-DJ, a Retargeted Gene Therapy Vector: Cryo-Electron Microscopy at 4.5 Aa Resolution

AAV-DJ, a leading candidate vector for liver gene therapy, was created through random homologous recombination followed by directed evolution, selecting for in vivo liver tropism and resistance to in vitro immune neutralization. Here, the 4.5 Aa resolution cryo-EM structure is determined for the eng...

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Veröffentlicht in:	Structure (London) 2012-08, Vol.20 (8), p.1310-1320
Hauptverfasser:	Lerch, Thomas F, O'Donnell, Jason K, Meyer, Nancy L, Xie, Qing, Taylor, Kenneth A, Stagg, Scott M, Chapman, Michael S
Format:	Artikel
Sprache:	eng
Schlagworte:	Adeno-associated virus Binding Gene therapy Liver Mathematical analysis Reconstruction Sulfates Tropism Vectors (mathematics)
Online-Zugang:	Volltext
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