Design of Digital Response in Enzyme-Based Bioanalytical Systems for Information Processing Applications
We investigate performance and optimization of the “digital” bioanalytical response. Specifically, we consider the recently introduced approach of a partial input conversion into inactive compounds, resulting in the “branch point effect” similar to that encountered in biological systems. This corres...
Gespeichert in:
| Veröffentlicht in: | The journal of physical chemistry. B 2012-11, Vol.116 (46), p.13690-13695 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 13695 |
|---|---|
| container_issue | 46 |
| container_start_page | 13690 |
| container_title | The journal of physical chemistry. B |
| container_volume | 116 |
| creator | Domanskyi, Sergii Privman, Vladimir |
| description | We investigate performance and optimization of the “digital” bioanalytical response. Specifically, we consider the recently introduced approach of a partial input conversion into inactive compounds, resulting in the “branch point effect” similar to that encountered in biological systems. This corresponds to an “intensity filter,” which can yield a binary-type sigmoid-response output signal of interest in information and signal processing and in biosensing applications. We define measures for optimizing the response for information processing applications based on the kinetic modeling of the enzymatic reactions involved, and apply the developed approach to the recently published data for glucose detection. |
| doi_str_mv | 10.1021/jp309001j |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1753528762</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1220365441</sourcerecordid><originalsourceid>FETCH-LOGICAL-a383t-add247e9ec93b222bd59803a01d85721a06917ef16dd4eed9c19711445677dba3</originalsourceid><addsrcrecordid>eNqF0btOwzAUBmALgWgpDLwA8oIEQ8B2Lk7G3oBKlUBc5siNT4qrxA456VCeHlctnZAYbB9Zn_7hP4RccnbHmeD3qyZkGWN8dUT6PBYs8Ece7-eEs6RHzhBXjIlYpMkp6QnvUyGiPvmcAJqlpa6kE7M0naroK2DjLAI1lk7t96aGYKQQNB0Zp6yqNp0pPHvbYAc10tK1dGb9XavOOEtfWlcAorFLOmyaytvtN56Tk1JVCBf7d0A-Hqbv46dg_vw4Gw_ngQrTsAuU1iKSkEGRhQshxELHWcpCxbhOYym4YknGJZQ80ToC0FnBM8l5FMWJlHqhwgG52eU2rftaA3Z5bbCAqlIW3BpzLuPQtyAT8T8VgoVJHEXc09sdLVqH2EKZN62pVbvJOcu3O8gPO_D2ah-7XtSgD_K3dA-ud0AVmK_cuvWl4h9BP0E-jXE</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1220365441</pqid></control><display><type>article</type><title>Design of Digital Response in Enzyme-Based Bioanalytical Systems for Information Processing Applications</title><source>MEDLINE</source><source>ACS Publications</source><creator>Domanskyi, Sergii ; Privman, Vladimir</creator><creatorcontrib>Domanskyi, Sergii ; Privman, Vladimir</creatorcontrib><description>We investigate performance and optimization of the “digital” bioanalytical response. Specifically, we consider the recently introduced approach of a partial input conversion into inactive compounds, resulting in the “branch point effect” similar to that encountered in biological systems. This corresponds to an “intensity filter,” which can yield a binary-type sigmoid-response output signal of interest in information and signal processing and in biosensing applications. We define measures for optimizing the response for information processing applications based on the kinetic modeling of the enzymatic reactions involved, and apply the developed approach to the recently published data for glucose detection.</description><identifier>ISSN: 1520-6106</identifier><identifier>EISSN: 1520-5207</identifier><identifier>DOI: 10.1021/jp309001j</identifier><identifier>PMID: 23098224</identifier><language>eng</language><publisher>United States: American Chemical Society</publisher><subject>Automatic Data Processing ; Biosensing Techniques - instrumentation ; Conversion ; Data processing ; Design engineering ; Digital ; Glucose ; Optimization ; Physical chemistry ; Signal processing ; Signal Processing, Computer-Assisted</subject><ispartof>The journal of physical chemistry. B, 2012-11, Vol.116 (46), p.13690-13695</ispartof><rights>Copyright © 2012 American Chemical Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a383t-add247e9ec93b222bd59803a01d85721a06917ef16dd4eed9c19711445677dba3</citedby><cites>FETCH-LOGICAL-a383t-add247e9ec93b222bd59803a01d85721a06917ef16dd4eed9c19711445677dba3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/jp309001j$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/jp309001j$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,780,784,2765,27076,27924,27925,56738,56788</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23098224$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Domanskyi, Sergii</creatorcontrib><creatorcontrib>Privman, Vladimir</creatorcontrib><title>Design of Digital Response in Enzyme-Based Bioanalytical Systems for Information Processing Applications</title><title>The journal of physical chemistry. B</title><addtitle>J. Phys. Chem. B</addtitle><description>We investigate performance and optimization of the “digital” bioanalytical response. Specifically, we consider the recently introduced approach of a partial input conversion into inactive compounds, resulting in the “branch point effect” similar to that encountered in biological systems. This corresponds to an “intensity filter,” which can yield a binary-type sigmoid-response output signal of interest in information and signal processing and in biosensing applications. We define measures for optimizing the response for information processing applications based on the kinetic modeling of the enzymatic reactions involved, and apply the developed approach to the recently published data for glucose detection.</description><subject>Automatic Data Processing</subject><subject>Biosensing Techniques - instrumentation</subject><subject>Conversion</subject><subject>Data processing</subject><subject>Design engineering</subject><subject>Digital</subject><subject>Glucose</subject><subject>Optimization</subject><subject>Physical chemistry</subject><subject>Signal processing</subject><subject>Signal Processing, Computer-Assisted</subject><issn>1520-6106</issn><issn>1520-5207</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0btOwzAUBmALgWgpDLwA8oIEQ8B2Lk7G3oBKlUBc5siNT4qrxA456VCeHlctnZAYbB9Zn_7hP4RccnbHmeD3qyZkGWN8dUT6PBYs8Ece7-eEs6RHzhBXjIlYpMkp6QnvUyGiPvmcAJqlpa6kE7M0naroK2DjLAI1lk7t96aGYKQQNB0Zp6yqNp0pPHvbYAc10tK1dGb9XavOOEtfWlcAorFLOmyaytvtN56Tk1JVCBf7d0A-Hqbv46dg_vw4Gw_ngQrTsAuU1iKSkEGRhQshxELHWcpCxbhOYym4YknGJZQ80ToC0FnBM8l5FMWJlHqhwgG52eU2rftaA3Z5bbCAqlIW3BpzLuPQtyAT8T8VgoVJHEXc09sdLVqH2EKZN62pVbvJOcu3O8gPO_D2ah-7XtSgD_K3dA-ud0AVmK_cuvWl4h9BP0E-jXE</recordid><startdate>20121126</startdate><enddate>20121126</enddate><creator>Domanskyi, Sergii</creator><creator>Privman, Vladimir</creator><general>American Chemical Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>L7M</scope></search><sort><creationdate>20121126</creationdate><title>Design of Digital Response in Enzyme-Based Bioanalytical Systems for Information Processing Applications</title><author>Domanskyi, Sergii ; Privman, Vladimir</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a383t-add247e9ec93b222bd59803a01d85721a06917ef16dd4eed9c19711445677dba3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Automatic Data Processing</topic><topic>Biosensing Techniques - instrumentation</topic><topic>Conversion</topic><topic>Data processing</topic><topic>Design engineering</topic><topic>Digital</topic><topic>Glucose</topic><topic>Optimization</topic><topic>Physical chemistry</topic><topic>Signal processing</topic><topic>Signal Processing, Computer-Assisted</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Domanskyi, Sergii</creatorcontrib><creatorcontrib>Privman, Vladimir</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>The journal of physical chemistry. B</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Domanskyi, Sergii</au><au>Privman, Vladimir</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Design of Digital Response in Enzyme-Based Bioanalytical Systems for Information Processing Applications</atitle><jtitle>The journal of physical chemistry. B</jtitle><addtitle>J. Phys. Chem. B</addtitle><date>2012-11-26</date><risdate>2012</risdate><volume>116</volume><issue>46</issue><spage>13690</spage><epage>13695</epage><pages>13690-13695</pages><issn>1520-6106</issn><eissn>1520-5207</eissn><abstract>We investigate performance and optimization of the “digital” bioanalytical response. Specifically, we consider the recently introduced approach of a partial input conversion into inactive compounds, resulting in the “branch point effect” similar to that encountered in biological systems. This corresponds to an “intensity filter,” which can yield a binary-type sigmoid-response output signal of interest in information and signal processing and in biosensing applications. We define measures for optimizing the response for information processing applications based on the kinetic modeling of the enzymatic reactions involved, and apply the developed approach to the recently published data for glucose detection.</abstract><cop>United States</cop><pub>American Chemical Society</pub><pmid>23098224</pmid><doi>10.1021/jp309001j</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1520-6106 |
| ispartof | The journal of physical chemistry. B, 2012-11, Vol.116 (46), p.13690-13695 |
| issn | 1520-6106 1520-5207 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1753528762 |
| source | MEDLINE; ACS Publications |
| subjects | Automatic Data Processing Biosensing Techniques - instrumentation Conversion Data processing Design engineering Digital Glucose Optimization Physical chemistry Signal processing Signal Processing, Computer-Assisted |
| title | Design of Digital Response in Enzyme-Based Bioanalytical Systems for Information Processing Applications |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-04T12%3A24%3A12IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Design%20of%20Digital%20Response%20in%20Enzyme-Based%20Bioanalytical%20Systems%20for%20Information%20Processing%20Applications&rft.jtitle=The%20journal%20of%20physical%20chemistry.%20B&rft.au=Domanskyi,%20Sergii&rft.date=2012-11-26&rft.volume=116&rft.issue=46&rft.spage=13690&rft.epage=13695&rft.pages=13690-13695&rft.issn=1520-6106&rft.eissn=1520-5207&rft_id=info:doi/10.1021/jp309001j&rft_dat=%3Cproquest_cross%3E1220365441%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1220365441&rft_id=info:pmid/23098224&rfr_iscdi=true |