Maternal iNOS genetic polymorphisms and hypertensive disorders of pregnancy
Increased expression and activity of inducible nitric oxide synthase (iNOS) may contribute to the pathogenesis of pre-eclampsia (PE) and gestational hypertension (GH). However, no previous study has examined whether genetic polymorphisms in the iNOS gene are associated with PE or GH. We examined whe...
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| Veröffentlicht in: | Journal of human hypertension 2012-09, Vol.26 (9), p.547-552 |
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| creator | Amaral, L M Palei, A C T Sandrim, V C Luizon, M R Cavalli, R C Duarte, G Tanus-Santos, J E |
| description | Increased expression and activity of inducible nitric oxide synthase (iNOS) may contribute to the pathogenesis of pre-eclampsia (PE) and gestational hypertension (GH). However, no previous study has examined whether genetic polymorphisms in the
iNOS
gene are associated with PE or GH. We examined whether two functional, clinically relevant iNOS genetic polymorphisms (the C
−1026
A polymorphism, rs2779249, in the promoter region, and the G2087A polymorphism, rs2297518, in exon 16) are associated with GH or with PE. We studied 565 pregnant women: 212 healthy pregnant (HP), 166 pregnant with GH and 187 pregnant with PE. Genotypes were determined by real-time PCR, using the Taqman allele discrimination assay. The PHASE 2.1 program was used to estimate haplotype distributions in the three study groups. We found no significant association between the C
−1026
A polymorphism and PE or GH (
P
>0.05). However, we found the GA genotype and the A allele for the G2087A polymorphism at higher frequency in PE, but not in GH, compared with HP (
P
0.05). These findings suggest that iNOS genetic variants may affect the susceptibility to PE, but not to GH. |
| doi_str_mv | 10.1038/jhh.2011.65 |
| format | Article |
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iNOS
gene are associated with PE or GH. We examined whether two functional, clinically relevant iNOS genetic polymorphisms (the C
−1026
A polymorphism, rs2779249, in the promoter region, and the G2087A polymorphism, rs2297518, in exon 16) are associated with GH or with PE. We studied 565 pregnant women: 212 healthy pregnant (HP), 166 pregnant with GH and 187 pregnant with PE. Genotypes were determined by real-time PCR, using the Taqman allele discrimination assay. The PHASE 2.1 program was used to estimate haplotype distributions in the three study groups. We found no significant association between the C
−1026
A polymorphism and PE or GH (
P
>0.05). However, we found the GA genotype and the A allele for the G2087A polymorphism at higher frequency in PE, but not in GH, compared with HP (
P
<0.05). The haplotype analysis showed no significant intergroup differences (
P
>0.05). These findings suggest that iNOS genetic variants may affect the susceptibility to PE, but not to GH.</description><identifier>ISSN: 0950-9240</identifier><identifier>EISSN: 1476-5527</identifier><identifier>DOI: 10.1038/jhh.2011.65</identifier><identifier>PMID: 21716319</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/208/726/649 ; 631/208/727/2000 ; 692/699/75/243/793 ; Adult ; Alleles ; Arterial hypertension. Arterial hypotension ; Biological and medical sciences ; Blood and lymphatic vessels ; Cardiology. Vascular system ; Care and treatment ; Clinical manifestations. Epidemiology. Investigative techniques. Etiology ; Diagnosis ; Epidemiology ; Exons ; Female ; Gene Frequency ; Gene polymorphism ; Genetic aspects ; Genetic Association Studies ; Genetic diversity ; Genetic polymorphisms ; Genetic Predisposition to Disease ; Genotype ; Haplotypes ; Health Administration ; Humans ; Hypertension in pregnancy ; Hypertension, Pregnancy-Induced - genetics ; Identification and classification ; Medical sciences ; Medicine ; Medicine & Public Health ; Nitric oxide ; Nitric Oxide Synthase Type II - genetics ; Nitric-oxide synthase ; original-article ; Polymorphism ; Polymorphism, Genetic ; Pre-eclampsia ; Pre-Eclampsia - genetics ; Preeclampsia ; Pregnancy ; Public Health ; Young Adult</subject><ispartof>Journal of human hypertension, 2012-09, Vol.26 (9), p.547-552</ispartof><rights>Macmillan Publishers Limited 2012</rights><rights>2015 INIST-CNRS</rights><rights>COPYRIGHT 2012 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Sep 2012</rights><rights>Macmillan Publishers Limited 2012.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c567t-e1f16e754e9837bcf56ba02b67ff78cedbd30b5a226745539a6adc5b1d044f583</citedby><cites>FETCH-LOGICAL-c567t-e1f16e754e9837bcf56ba02b67ff78cedbd30b5a226745539a6adc5b1d044f583</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27926,27927</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26250098$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21716319$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Amaral, L M</creatorcontrib><creatorcontrib>Palei, A C T</creatorcontrib><creatorcontrib>Sandrim, V C</creatorcontrib><creatorcontrib>Luizon, M R</creatorcontrib><creatorcontrib>Cavalli, R C</creatorcontrib><creatorcontrib>Duarte, G</creatorcontrib><creatorcontrib>Tanus-Santos, J E</creatorcontrib><title>Maternal iNOS genetic polymorphisms and hypertensive disorders of pregnancy</title><title>Journal of human hypertension</title><addtitle>J Hum Hypertens</addtitle><addtitle>J Hum Hypertens</addtitle><description>Increased expression and activity of inducible nitric oxide synthase (iNOS) may contribute to the pathogenesis of pre-eclampsia (PE) and gestational hypertension (GH). However, no previous study has examined whether genetic polymorphisms in the
iNOS
gene are associated with PE or GH. We examined whether two functional, clinically relevant iNOS genetic polymorphisms (the C
−1026
A polymorphism, rs2779249, in the promoter region, and the G2087A polymorphism, rs2297518, in exon 16) are associated with GH or with PE. We studied 565 pregnant women: 212 healthy pregnant (HP), 166 pregnant with GH and 187 pregnant with PE. Genotypes were determined by real-time PCR, using the Taqman allele discrimination assay. The PHASE 2.1 program was used to estimate haplotype distributions in the three study groups. We found no significant association between the C
−1026
A polymorphism and PE or GH (
P
>0.05). However, we found the GA genotype and the A allele for the G2087A polymorphism at higher frequency in PE, but not in GH, compared with HP (
P
<0.05). The haplotype analysis showed no significant intergroup differences (
P
>0.05). These findings suggest that iNOS genetic variants may affect the susceptibility to PE, but not to GH.</description><subject>631/208/726/649</subject><subject>631/208/727/2000</subject><subject>692/699/75/243/793</subject><subject>Adult</subject><subject>Alleles</subject><subject>Arterial hypertension. Arterial hypotension</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Cardiology. Vascular system</subject><subject>Care and treatment</subject><subject>Clinical manifestations. Epidemiology. Investigative techniques. Etiology</subject><subject>Diagnosis</subject><subject>Epidemiology</subject><subject>Exons</subject><subject>Female</subject><subject>Gene Frequency</subject><subject>Gene polymorphism</subject><subject>Genetic aspects</subject><subject>Genetic Association Studies</subject><subject>Genetic diversity</subject><subject>Genetic polymorphisms</subject><subject>Genetic Predisposition to Disease</subject><subject>Genotype</subject><subject>Haplotypes</subject><subject>Health Administration</subject><subject>Humans</subject><subject>Hypertension in pregnancy</subject><subject>Hypertension, Pregnancy-Induced - genetics</subject><subject>Identification and classification</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Nitric oxide</subject><subject>Nitric Oxide Synthase Type II - genetics</subject><subject>Nitric-oxide synthase</subject><subject>original-article</subject><subject>Polymorphism</subject><subject>Polymorphism, Genetic</subject><subject>Pre-eclampsia</subject><subject>Pre-Eclampsia - genetics</subject><subject>Preeclampsia</subject><subject>Pregnancy</subject><subject>Public Health</subject><subject>Young Adult</subject><issn>0950-9240</issn><issn>1476-5527</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqF0s2L1DAUAPAiijuunrxrQRRBO-Y77XFZ1g9c3YN6Lmn6Ms3QJt2kFea_35QZ90MWJYdA8svLy8vLsucYrTGi5Ydt160Jwngt-INshZkUBedEPsxWqOKoqAhDR9mTGLcILZvl4-yIYIkFxdUq-_pNTRCc6nP7_eJHvgEHk9X56Pvd4MPY2TjEXLk273YjhAlctL8hb230oYUQc2_yMcDGKad3T7NHRvURnh3m4-zXx7Ofp5-L84tPX05PzgvNhZwKwAYLkJxBVVLZaMNFoxBphDRGlhrapqWo4YoQIRnntFJCtZo3uEWMGV7S4-ztPu4Y_OUMcaoHGzX0vXLg51hjyWkqgED4_xRRRhCiYqGv_qJbPy-ViTURDAmBK87-pVIsyjmTmN-ojeqhts74KSi9XF2fUIQ5F0jIpNb3qDRaGKz2DoxN63cOvLl1oAPVT130_TxZ7-Jd-G4PdfAxBjD1GOygwi4lueRZ1qlp6qVparFk--LwprkZoL22f7okgdcHoKJWvQnpt228cYJwhKrlY97vXUxbbgPhdnHuu_flnjs1zQGu4yWzkCSuAAZe3p4</recordid><startdate>20120901</startdate><enddate>20120901</enddate><creator>Amaral, L M</creator><creator>Palei, A C T</creator><creator>Sandrim, V C</creator><creator>Luizon, M R</creator><creator>Cavalli, R C</creator><creator>Duarte, G</creator><creator>Tanus-Santos, J E</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope></search><sort><creationdate>20120901</creationdate><title>Maternal iNOS genetic polymorphisms and hypertensive disorders of pregnancy</title><author>Amaral, L M ; Palei, A C T ; Sandrim, V C ; Luizon, M R ; Cavalli, R C ; Duarte, G ; Tanus-Santos, J E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c567t-e1f16e754e9837bcf56ba02b67ff78cedbd30b5a226745539a6adc5b1d044f583</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>631/208/726/649</topic><topic>631/208/727/2000</topic><topic>692/699/75/243/793</topic><topic>Adult</topic><topic>Alleles</topic><topic>Arterial hypertension. Arterial hypotension</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Cardiology. Vascular system</topic><topic>Care and treatment</topic><topic>Clinical manifestations. Epidemiology. Investigative techniques. Etiology</topic><topic>Diagnosis</topic><topic>Epidemiology</topic><topic>Exons</topic><topic>Female</topic><topic>Gene Frequency</topic><topic>Gene polymorphism</topic><topic>Genetic aspects</topic><topic>Genetic Association Studies</topic><topic>Genetic diversity</topic><topic>Genetic polymorphisms</topic><topic>Genetic Predisposition to Disease</topic><topic>Genotype</topic><topic>Haplotypes</topic><topic>Health Administration</topic><topic>Humans</topic><topic>Hypertension in pregnancy</topic><topic>Hypertension, Pregnancy-Induced - genetics</topic><topic>Identification and classification</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Nitric oxide</topic><topic>Nitric Oxide Synthase Type II - genetics</topic><topic>Nitric-oxide synthase</topic><topic>original-article</topic><topic>Polymorphism</topic><topic>Polymorphism, Genetic</topic><topic>Pre-eclampsia</topic><topic>Pre-Eclampsia - genetics</topic><topic>Preeclampsia</topic><topic>Pregnancy</topic><topic>Public Health</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Amaral, L M</creatorcontrib><creatorcontrib>Palei, A C T</creatorcontrib><creatorcontrib>Sandrim, V C</creatorcontrib><creatorcontrib>Luizon, M R</creatorcontrib><creatorcontrib>Cavalli, R C</creatorcontrib><creatorcontrib>Duarte, G</creatorcontrib><creatorcontrib>Tanus-Santos, J E</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><jtitle>Journal of human hypertension</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Amaral, L M</au><au>Palei, A C T</au><au>Sandrim, V C</au><au>Luizon, M R</au><au>Cavalli, R C</au><au>Duarte, G</au><au>Tanus-Santos, J E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Maternal iNOS genetic polymorphisms and hypertensive disorders of pregnancy</atitle><jtitle>Journal of human hypertension</jtitle><stitle>J Hum Hypertens</stitle><addtitle>J Hum Hypertens</addtitle><date>2012-09-01</date><risdate>2012</risdate><volume>26</volume><issue>9</issue><spage>547</spage><epage>552</epage><pages>547-552</pages><issn>0950-9240</issn><eissn>1476-5527</eissn><abstract>Increased expression and activity of inducible nitric oxide synthase (iNOS) may contribute to the pathogenesis of pre-eclampsia (PE) and gestational hypertension (GH). However, no previous study has examined whether genetic polymorphisms in the
iNOS
gene are associated with PE or GH. We examined whether two functional, clinically relevant iNOS genetic polymorphisms (the C
−1026
A polymorphism, rs2779249, in the promoter region, and the G2087A polymorphism, rs2297518, in exon 16) are associated with GH or with PE. We studied 565 pregnant women: 212 healthy pregnant (HP), 166 pregnant with GH and 187 pregnant with PE. Genotypes were determined by real-time PCR, using the Taqman allele discrimination assay. The PHASE 2.1 program was used to estimate haplotype distributions in the three study groups. We found no significant association between the C
−1026
A polymorphism and PE or GH (
P
>0.05). However, we found the GA genotype and the A allele for the G2087A polymorphism at higher frequency in PE, but not in GH, compared with HP (
P
<0.05). The haplotype analysis showed no significant intergroup differences (
P
>0.05). These findings suggest that iNOS genetic variants may affect the susceptibility to PE, but not to GH.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>21716319</pmid><doi>10.1038/jhh.2011.65</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
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| ispartof | Journal of human hypertension, 2012-09, Vol.26 (9), p.547-552 |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | 631/208/726/649 631/208/727/2000 692/699/75/243/793 Adult Alleles Arterial hypertension. Arterial hypotension Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Care and treatment Clinical manifestations. Epidemiology. Investigative techniques. Etiology Diagnosis Epidemiology Exons Female Gene Frequency Gene polymorphism Genetic aspects Genetic Association Studies Genetic diversity Genetic polymorphisms Genetic Predisposition to Disease Genotype Haplotypes Health Administration Humans Hypertension in pregnancy Hypertension, Pregnancy-Induced - genetics Identification and classification Medical sciences Medicine Medicine & Public Health Nitric oxide Nitric Oxide Synthase Type II - genetics Nitric-oxide synthase original-article Polymorphism Polymorphism, Genetic Pre-eclampsia Pre-Eclampsia - genetics Preeclampsia Pregnancy Public Health Young Adult |
| title | Maternal iNOS genetic polymorphisms and hypertensive disorders of pregnancy |
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