The differential effect of apoferritin-PbS nanocomposites on cell cycle progression in normal and cancerous cells
We report the effects induced by near-infrared apoferritin-PbS (AFt-PbS) nanocomposites on cell cycle progression in non-tumorigenic and cancerous human cells. By using flow cytometry and Annexin V assay, we show that the cell cycle of non-tumorigenic cells is not altered by exposure to AFt-PbS nano...
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| Veröffentlicht in: | Journal of materials chemistry 2012-01, Vol.22 (2), p.660-665 |
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| container_end_page | 665 |
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| container_title | Journal of materials chemistry |
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| creator | Turyanska, Lyudmila Bradshaw, Tracey D Li, Mei Bardelang, Philip Drewe, William C Fay, Michael W Mann, Stephen Patane, Amalia Thomas, Neil R |
| description | We report the effects induced by near-infrared apoferritin-PbS (AFt-PbS) nanocomposites on cell cycle progression in non-tumorigenic and cancerous human cells. By using flow cytometry and Annexin V assay, we show that the cell cycle of non-tumorigenic cells is not altered by exposure to AFt-PbS nanoparticles at concentrations up to 1 mg mL super(-1). In contrast, exposure of human-derived breast cancer cell lines to AFt-PbS at concentrations > 0.2 mg mL super(-1) triggers apoptotic cell death. The selective death of cancerous cells and the near-infrared fluorescence properties of AFt-PbS could be exploited in both nanomedicine and in vivoimaging studies. |
| doi_str_mv | 10.1039/C1JM13563E |
| format | Article |
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By using flow cytometry and Annexin V assay, we show that the cell cycle of non-tumorigenic cells is not altered by exposure to AFt-PbS nanoparticles at concentrations up to 1 mg mL super(-1). In contrast, exposure of human-derived breast cancer cell lines to AFt-PbS at concentrations > 0.2 mg mL super(-1) triggers apoptotic cell death. 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By using flow cytometry and Annexin V assay, we show that the cell cycle of non-tumorigenic cells is not altered by exposure to AFt-PbS nanoparticles at concentrations up to 1 mg mL super(-1). In contrast, exposure of human-derived breast cancer cell lines to AFt-PbS at concentrations > 0.2 mg mL super(-1) triggers apoptotic cell death. 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| identifier | ISSN: 0959-9428 |
| ispartof | Journal of materials chemistry, 2012-01, Vol.22 (2), p.660-665 |
| issn | 0959-9428 1364-5501 |
| language | eng |
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| source | Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| subjects | Breast Cell death Flow cytometry Human Imaging Nanocomposites Nanomaterials Nanoparticles Nanostructure Progressions Surgical implants |
| title | The differential effect of apoferritin-PbS nanocomposites on cell cycle progression in normal and cancerous cells |
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