Moderate effects of apple juice consumption on obesity-related markers in obese men: impact of diet–gene interaction on body fat content
Purpose The effect of polyphenol-rich cloudy apple juice (CloA) consumption on plasma parameters related to the obesity phenotype and potential effects of interactions between CloA and allelic variants in obesity candidate genes were assessed in obese men. Methods In this controlled, randomized, and...
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| Veröffentlicht in: | European journal of nutrition 2012-10, Vol.51 (7), p.841-850 |
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| creator | Barth, Stephan W. Koch, Tatiana C. L. Watzl, Bernhard Dietrich, Helmut Will, Frank Bub, Achim |
| description | Purpose
The effect of polyphenol-rich cloudy apple juice (CloA) consumption on plasma parameters related to the obesity phenotype and potential effects of interactions between CloA and allelic variants in obesity candidate genes were assessed in obese men.
Methods
In this controlled, randomized, and parallel study,
n
= 68, non-smoking, non-diabetic men with a BMI ≥27 kg/m
2
received 750 mL/day CloA (802.5 mg polyphenols) or 750 mL/day control beverage (CB, isocaloric equivalent to CloA) for 4 weeks. Further, study participants were genotyped for single-nucleotide polymorphisms in PPARγ (rs1801282), UCP3 (rs1800849), IL-6 (rs1800795), FABP2 (rs1799883), INSIG2 (rs7566605), and PGC1 (rs8192678) genes. At the beginning and at the end of intervention plasma lipids, distinct adipokines and cytokines as well as anthropometric parameters were determined.
Results
CloA compared to CB had no significant effect on plasma lipids, plasma adipokine and cytokine levels, BMI, and waist circumference. However, CloA consumption significantly reduced percent body fat compared to CB (∆ % body fat: CloA: −1.0 ± 1.3 vs. CB: −0.2 ± 0.9,
p
|
| doi_str_mv | 10.1007/s00394-011-0264-6 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1753522906</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1753522906</sourcerecordid><originalsourceid>FETCH-LOGICAL-c435t-83a735cec798b1bdd67370318049267932a4176637fe766bc6269687ceba6cbe3</originalsourceid><addsrcrecordid>eNqFkc-K1TAUxoMozjj6AG4kIMJsOuZPe9K6GwZHhRE3ui5pejrk2iY1SRd359qtb-iTTErvjMOACIETOL_zfSf5CHnJ2RlnTL2NjMmmLBjnBRNQFvCIHPNSQgGCV4_v7kwdkWcx7hhjQgJ_So6EYLIuoTwmvz77HoNOSHEY0KRI_UD1PI9Id4s1SI13cZnmZL2j6-kw2rQvAo55qKeTDt8xRGq3FtIJ3Ttqp1mbtEr1FtOfn7-v0WFmUrYyt1Kd7_d00Gm1SOjSc_Jk0GPEF4d6Qr5dvv968bG4-vLh08X5VWFKWaWillrJyqBRTd3xru9BScUkr1nZCFCNFLrkCkCqAXPpDAhooFYGOw2mQ3lCTjfdOfgfC8bUTjYaHEft0C-x5aqSlRANg_-jrGbAK8HrjL5-gO78Elx-SKagkTmquskU3ygTfIwBh3YONv_hPkPtmmm7ZdrmTNs103Zd4tVBeekm7O8mbkPMwJsDoKPR4xC0Mzb-5SA7s1JkTmxczC13jeH-iv9yvwGYtrm8</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1069300389</pqid></control><display><type>article</type><title>Moderate effects of apple juice consumption on obesity-related markers in obese men: impact of diet–gene interaction on body fat content</title><source>MEDLINE</source><source>SpringerNature Journals</source><creator>Barth, Stephan W. ; Koch, Tatiana C. L. ; Watzl, Bernhard ; Dietrich, Helmut ; Will, Frank ; Bub, Achim</creator><creatorcontrib>Barth, Stephan W. ; Koch, Tatiana C. L. ; Watzl, Bernhard ; Dietrich, Helmut ; Will, Frank ; Bub, Achim</creatorcontrib><description>Purpose
The effect of polyphenol-rich cloudy apple juice (CloA) consumption on plasma parameters related to the obesity phenotype and potential effects of interactions between CloA and allelic variants in obesity candidate genes were assessed in obese men.
Methods
In this controlled, randomized, and parallel study,
n
= 68, non-smoking, non-diabetic men with a BMI ≥27 kg/m
2
received 750 mL/day CloA (802.5 mg polyphenols) or 750 mL/day control beverage (CB, isocaloric equivalent to CloA) for 4 weeks. Further, study participants were genotyped for single-nucleotide polymorphisms in PPARγ (rs1801282), UCP3 (rs1800849), IL-6 (rs1800795), FABP2 (rs1799883), INSIG2 (rs7566605), and PGC1 (rs8192678) genes. At the beginning and at the end of intervention plasma lipids, distinct adipokines and cytokines as well as anthropometric parameters were determined.
Results
CloA compared to CB had no significant effect on plasma lipids, plasma adipokine and cytokine levels, BMI, and waist circumference. However, CloA consumption significantly reduced percent body fat compared to CB (∆ % body fat: CloA: −1.0 ± 1.3 vs. CB: −0.2 ± 0.9,
p
< 0.05). The IL-6-174 G/C polymorphism showed an interaction with body fat reduction induced by CloA. Solely in C/C, but not in G/C or G/G variants, a significant reduction in body fat after 4 weeks of CloA intervention was detectable.
Conclusion
The observed diet–gene interaction might be a first indication for the impact of individual genetic background on CloA-mediated bioactivity on obesity-associated comorbidities.</description><identifier>ISSN: 1436-6207</identifier><identifier>EISSN: 1436-6215</identifier><identifier>DOI: 10.1007/s00394-011-0264-6</identifier><identifier>PMID: 22038464</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Adipokines - blood ; Adipose Tissue - metabolism ; Adult ; Aged ; Alleles ; Beverages ; Biological and medical sciences ; Body Composition ; Body fat ; Body Mass Index ; Chemistry ; Chemistry and Materials Science ; Diet ; Fatty Acid-Binding Proteins - genetics ; Fatty Acid-Binding Proteins - metabolism ; Feeding. Feeding behavior ; Fundamental and applied biological sciences. Psychology ; Gene-Environment Interaction ; Genetic Markers ; Genotype ; Humans ; Interleukin-6 - blood ; Interleukin-6 - genetics ; Intracellular Signaling Peptides and Proteins - genetics ; Intracellular Signaling Peptides and Proteins - metabolism ; Ion Channels - genetics ; Ion Channels - metabolism ; Lipids - blood ; Male ; Malus ; Malus - chemistry ; Medical sciences ; Membrane Proteins - genetics ; Membrane Proteins - metabolism ; Metabolic diseases ; Middle Aged ; Mitochondrial Proteins - genetics ; Mitochondrial Proteins - metabolism ; Nutrition ; Obesity ; Obesity - genetics ; Obesity - physiopathology ; Original Contribution ; Polymorphism, Single Nucleotide ; PPAR gamma - genetics ; PPAR gamma - metabolism ; Sequence Analysis, DNA ; Uncoupling Protein 3 ; Vertebrates: anatomy and physiology, studies on body, several organs or systems ; Waist Circumference ; Young Adult</subject><ispartof>European journal of nutrition, 2012-10, Vol.51 (7), p.841-850</ispartof><rights>Springer-Verlag 2011</rights><rights>2015 INIST-CNRS</rights><rights>Springer-Verlag Berlin Heidelberg 2012</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c435t-83a735cec798b1bdd67370318049267932a4176637fe766bc6269687ceba6cbe3</citedby><cites>FETCH-LOGICAL-c435t-83a735cec798b1bdd67370318049267932a4176637fe766bc6269687ceba6cbe3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00394-011-0264-6$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00394-011-0264-6$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26389042$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22038464$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Barth, Stephan W.</creatorcontrib><creatorcontrib>Koch, Tatiana C. L.</creatorcontrib><creatorcontrib>Watzl, Bernhard</creatorcontrib><creatorcontrib>Dietrich, Helmut</creatorcontrib><creatorcontrib>Will, Frank</creatorcontrib><creatorcontrib>Bub, Achim</creatorcontrib><title>Moderate effects of apple juice consumption on obesity-related markers in obese men: impact of diet–gene interaction on body fat content</title><title>European journal of nutrition</title><addtitle>Eur J Nutr</addtitle><addtitle>Eur J Nutr</addtitle><description>Purpose
The effect of polyphenol-rich cloudy apple juice (CloA) consumption on plasma parameters related to the obesity phenotype and potential effects of interactions between CloA and allelic variants in obesity candidate genes were assessed in obese men.
Methods
In this controlled, randomized, and parallel study,
n
= 68, non-smoking, non-diabetic men with a BMI ≥27 kg/m
2
received 750 mL/day CloA (802.5 mg polyphenols) or 750 mL/day control beverage (CB, isocaloric equivalent to CloA) for 4 weeks. Further, study participants were genotyped for single-nucleotide polymorphisms in PPARγ (rs1801282), UCP3 (rs1800849), IL-6 (rs1800795), FABP2 (rs1799883), INSIG2 (rs7566605), and PGC1 (rs8192678) genes. At the beginning and at the end of intervention plasma lipids, distinct adipokines and cytokines as well as anthropometric parameters were determined.
Results
CloA compared to CB had no significant effect on plasma lipids, plasma adipokine and cytokine levels, BMI, and waist circumference. However, CloA consumption significantly reduced percent body fat compared to CB (∆ % body fat: CloA: −1.0 ± 1.3 vs. CB: −0.2 ± 0.9,
p
< 0.05). The IL-6-174 G/C polymorphism showed an interaction with body fat reduction induced by CloA. Solely in C/C, but not in G/C or G/G variants, a significant reduction in body fat after 4 weeks of CloA intervention was detectable.
Conclusion
The observed diet–gene interaction might be a first indication for the impact of individual genetic background on CloA-mediated bioactivity on obesity-associated comorbidities.</description><subject>Adipokines - blood</subject><subject>Adipose Tissue - metabolism</subject><subject>Adult</subject><subject>Aged</subject><subject>Alleles</subject><subject>Beverages</subject><subject>Biological and medical sciences</subject><subject>Body Composition</subject><subject>Body fat</subject><subject>Body Mass Index</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Diet</subject><subject>Fatty Acid-Binding Proteins - genetics</subject><subject>Fatty Acid-Binding Proteins - metabolism</subject><subject>Feeding. Feeding behavior</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene-Environment Interaction</subject><subject>Genetic Markers</subject><subject>Genotype</subject><subject>Humans</subject><subject>Interleukin-6 - blood</subject><subject>Interleukin-6 - genetics</subject><subject>Intracellular Signaling Peptides and Proteins - genetics</subject><subject>Intracellular Signaling Peptides and Proteins - metabolism</subject><subject>Ion Channels - genetics</subject><subject>Ion Channels - metabolism</subject><subject>Lipids - blood</subject><subject>Male</subject><subject>Malus</subject><subject>Malus - chemistry</subject><subject>Medical sciences</subject><subject>Membrane Proteins - genetics</subject><subject>Membrane Proteins - metabolism</subject><subject>Metabolic diseases</subject><subject>Middle Aged</subject><subject>Mitochondrial Proteins - genetics</subject><subject>Mitochondrial Proteins - metabolism</subject><subject>Nutrition</subject><subject>Obesity</subject><subject>Obesity - genetics</subject><subject>Obesity - physiopathology</subject><subject>Original Contribution</subject><subject>Polymorphism, Single Nucleotide</subject><subject>PPAR gamma - genetics</subject><subject>PPAR gamma - metabolism</subject><subject>Sequence Analysis, DNA</subject><subject>Uncoupling Protein 3</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><subject>Waist Circumference</subject><subject>Young Adult</subject><issn>1436-6207</issn><issn>1436-6215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNqFkc-K1TAUxoMozjj6AG4kIMJsOuZPe9K6GwZHhRE3ui5pejrk2iY1SRd359qtb-iTTErvjMOACIETOL_zfSf5CHnJ2RlnTL2NjMmmLBjnBRNQFvCIHPNSQgGCV4_v7kwdkWcx7hhjQgJ_So6EYLIuoTwmvz77HoNOSHEY0KRI_UD1PI9Id4s1SI13cZnmZL2j6-kw2rQvAo55qKeTDt8xRGq3FtIJ3Ttqp1mbtEr1FtOfn7-v0WFmUrYyt1Kd7_d00Gm1SOjSc_Jk0GPEF4d6Qr5dvv968bG4-vLh08X5VWFKWaWillrJyqBRTd3xru9BScUkr1nZCFCNFLrkCkCqAXPpDAhooFYGOw2mQ3lCTjfdOfgfC8bUTjYaHEft0C-x5aqSlRANg_-jrGbAK8HrjL5-gO78Elx-SKagkTmquskU3ygTfIwBh3YONv_hPkPtmmm7ZdrmTNs103Zd4tVBeekm7O8mbkPMwJsDoKPR4xC0Mzb-5SA7s1JkTmxczC13jeH-iv9yvwGYtrm8</recordid><startdate>20121001</startdate><enddate>20121001</enddate><creator>Barth, Stephan W.</creator><creator>Koch, Tatiana C. L.</creator><creator>Watzl, Bernhard</creator><creator>Dietrich, Helmut</creator><creator>Will, Frank</creator><creator>Bub, Achim</creator><general>Springer-Verlag</general><general>Springer</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RQ</scope><scope>7RV</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope></search><sort><creationdate>20121001</creationdate><title>Moderate effects of apple juice consumption on obesity-related markers in obese men: impact of diet–gene interaction on body fat content</title><author>Barth, Stephan W. ; Koch, Tatiana C. L. ; Watzl, Bernhard ; Dietrich, Helmut ; Will, Frank ; Bub, Achim</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c435t-83a735cec798b1bdd67370318049267932a4176637fe766bc6269687ceba6cbe3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adipokines - blood</topic><topic>Adipose Tissue - metabolism</topic><topic>Adult</topic><topic>Aged</topic><topic>Alleles</topic><topic>Beverages</topic><topic>Biological and medical sciences</topic><topic>Body Composition</topic><topic>Body fat</topic><topic>Body Mass Index</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Diet</topic><topic>Fatty Acid-Binding Proteins - genetics</topic><topic>Fatty Acid-Binding Proteins - metabolism</topic><topic>Feeding. Feeding behavior</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene-Environment Interaction</topic><topic>Genetic Markers</topic><topic>Genotype</topic><topic>Humans</topic><topic>Interleukin-6 - blood</topic><topic>Interleukin-6 - genetics</topic><topic>Intracellular Signaling Peptides and Proteins - genetics</topic><topic>Intracellular Signaling Peptides and Proteins - metabolism</topic><topic>Ion Channels - genetics</topic><topic>Ion Channels - metabolism</topic><topic>Lipids - blood</topic><topic>Male</topic><topic>Malus</topic><topic>Malus - chemistry</topic><topic>Medical sciences</topic><topic>Membrane Proteins - genetics</topic><topic>Membrane Proteins - metabolism</topic><topic>Metabolic diseases</topic><topic>Middle Aged</topic><topic>Mitochondrial Proteins - genetics</topic><topic>Mitochondrial Proteins - metabolism</topic><topic>Nutrition</topic><topic>Obesity</topic><topic>Obesity - genetics</topic><topic>Obesity - physiopathology</topic><topic>Original Contribution</topic><topic>Polymorphism, Single Nucleotide</topic><topic>PPAR gamma - genetics</topic><topic>PPAR gamma - metabolism</topic><topic>Sequence Analysis, DNA</topic><topic>Uncoupling Protein 3</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><topic>Waist Circumference</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Barth, Stephan W.</creatorcontrib><creatorcontrib>Koch, Tatiana C. L.</creatorcontrib><creatorcontrib>Watzl, Bernhard</creatorcontrib><creatorcontrib>Dietrich, Helmut</creatorcontrib><creatorcontrib>Will, Frank</creatorcontrib><creatorcontrib>Bub, Achim</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Career & Technical Education Database</collection><collection>Nursing & Allied Health Database</collection><collection>Physical Education Index</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><jtitle>European journal of nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Barth, Stephan W.</au><au>Koch, Tatiana C. L.</au><au>Watzl, Bernhard</au><au>Dietrich, Helmut</au><au>Will, Frank</au><au>Bub, Achim</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Moderate effects of apple juice consumption on obesity-related markers in obese men: impact of diet–gene interaction on body fat content</atitle><jtitle>European journal of nutrition</jtitle><stitle>Eur J Nutr</stitle><addtitle>Eur J Nutr</addtitle><date>2012-10-01</date><risdate>2012</risdate><volume>51</volume><issue>7</issue><spage>841</spage><epage>850</epage><pages>841-850</pages><issn>1436-6207</issn><eissn>1436-6215</eissn><abstract>Purpose
The effect of polyphenol-rich cloudy apple juice (CloA) consumption on plasma parameters related to the obesity phenotype and potential effects of interactions between CloA and allelic variants in obesity candidate genes were assessed in obese men.
Methods
In this controlled, randomized, and parallel study,
n
= 68, non-smoking, non-diabetic men with a BMI ≥27 kg/m
2
received 750 mL/day CloA (802.5 mg polyphenols) or 750 mL/day control beverage (CB, isocaloric equivalent to CloA) for 4 weeks. Further, study participants were genotyped for single-nucleotide polymorphisms in PPARγ (rs1801282), UCP3 (rs1800849), IL-6 (rs1800795), FABP2 (rs1799883), INSIG2 (rs7566605), and PGC1 (rs8192678) genes. At the beginning and at the end of intervention plasma lipids, distinct adipokines and cytokines as well as anthropometric parameters were determined.
Results
CloA compared to CB had no significant effect on plasma lipids, plasma adipokine and cytokine levels, BMI, and waist circumference. However, CloA consumption significantly reduced percent body fat compared to CB (∆ % body fat: CloA: −1.0 ± 1.3 vs. CB: −0.2 ± 0.9,
p
< 0.05). The IL-6-174 G/C polymorphism showed an interaction with body fat reduction induced by CloA. Solely in C/C, but not in G/C or G/G variants, a significant reduction in body fat after 4 weeks of CloA intervention was detectable.
Conclusion
The observed diet–gene interaction might be a first indication for the impact of individual genetic background on CloA-mediated bioactivity on obesity-associated comorbidities.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>22038464</pmid><doi>10.1007/s00394-011-0264-6</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | European journal of nutrition, 2012-10, Vol.51 (7), p.841-850 |
| issn | 1436-6207 1436-6215 |
| language | eng |
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| source | MEDLINE; SpringerNature Journals |
| subjects | Adipokines - blood Adipose Tissue - metabolism Adult Aged Alleles Beverages Biological and medical sciences Body Composition Body fat Body Mass Index Chemistry Chemistry and Materials Science Diet Fatty Acid-Binding Proteins - genetics Fatty Acid-Binding Proteins - metabolism Feeding. Feeding behavior Fundamental and applied biological sciences. Psychology Gene-Environment Interaction Genetic Markers Genotype Humans Interleukin-6 - blood Interleukin-6 - genetics Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - metabolism Ion Channels - genetics Ion Channels - metabolism Lipids - blood Male Malus Malus - chemistry Medical sciences Membrane Proteins - genetics Membrane Proteins - metabolism Metabolic diseases Middle Aged Mitochondrial Proteins - genetics Mitochondrial Proteins - metabolism Nutrition Obesity Obesity - genetics Obesity - physiopathology Original Contribution Polymorphism, Single Nucleotide PPAR gamma - genetics PPAR gamma - metabolism Sequence Analysis, DNA Uncoupling Protein 3 Vertebrates: anatomy and physiology, studies on body, several organs or systems Waist Circumference Young Adult |
| title | Moderate effects of apple juice consumption on obesity-related markers in obese men: impact of diet–gene interaction on body fat content |
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