Polyphosphate: A Morphogenetically Active Implant Material Serving as Metabolic Fuel for Bone Regeneration

The initial mineralization centers during human bone formation onto osteoblasts are composed of CaCO3. Those bioseeds are enzymatically formed via carbonic anhydrase(s) in close association with the cell surface of the osteoblasts. Subsequently, the bicarbonate/carbonate anions are exchanged non‐enz...

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Veröffentlicht in:	Macromolecular bioscience 2015-09, Vol.15 (9), p.1182-1197
Hauptverfasser:	Müller, Werner E. G., Tolba, Emad, Schröder, Heinz C., Wang, Xiaohong
Format:	Artikel
Sprache:	eng
Schlagworte:	Absorbable Implants Animals bone Bone Regeneration - drug effects Bone Regeneration - physiology Bones Calcification, Physiologic Calcium carbonate Humans Metabolism Mineralization morphogenetic activity Osteoblasts Osteoblasts - physiology Phosphates polyphosphate Polyphosphates Polyphosphates - metabolism Polyphosphates - therapeutic use regenerative medicine Scaffolds Surgical implants tissue engineering Tissue Scaffolds
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