Rapid and sensitive detection of melamine in milk with gold nanoparticles by Surface Enhanced Raman Scattering
•We present a rapid and sensitive method to detect melamine in milk based on SERS.•Interaction of melamine with AuNPs enhances melamine Raman signal in the analysis.•Different size AuNPs were tested to achieve the highest SERS enhancement.•Melamine detection in milk is in accordance with the Europea...
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| Veröffentlicht in: | Food chemistry 2014-09, Vol.159, p.250-256 |
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| creator | Giovannozzi, Andrea Mario Rolle, Francesca Sega, Michela Abete, Maria Cesarina Marchis, Daniela Rossi, Andrea Mario |
| description | •We present a rapid and sensitive method to detect melamine in milk based on SERS.•Interaction of melamine with AuNPs enhances melamine Raman signal in the analysis.•Different size AuNPs were tested to achieve the highest SERS enhancement.•Melamine detection in milk is in accordance with the European law limits.•SERS analysis is validated for sensitivity, linearity, recovery and repeatability.
A rapid and sensitive method to detect melamine in liquid milk based on Surface Enhanced Raman Scattering (SERS) spectroscopy is presented, exploiting the selective binding of gold nanoparticles (AuNPs) with this analyte. This interaction promotes the aggregation of the AuNPs inducing a huge enhancement of the melamine signals in the Raman spectrum due to the formation of SERS “hot spots”. An external standard calibration method was employed for quantitative analysis and the method was validated for linearity, sensitivity, repeatability and recovery. A good linearity (R2=0.99) was found in the concentration range of 0.31–5.0mgl−1 in milk with a limit of detection of 0.17mgl−1. This method does not require a long extraction procedure (total analysis time can be lower than 30min) and can be reliably used for melamine detection in milk matrix in accordance with the European law limits. |
| doi_str_mv | 10.1016/j.foodchem.2014.03.013 |
| format | Article |
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A rapid and sensitive method to detect melamine in liquid milk based on Surface Enhanced Raman Scattering (SERS) spectroscopy is presented, exploiting the selective binding of gold nanoparticles (AuNPs) with this analyte. This interaction promotes the aggregation of the AuNPs inducing a huge enhancement of the melamine signals in the Raman spectrum due to the formation of SERS “hot spots”. An external standard calibration method was employed for quantitative analysis and the method was validated for linearity, sensitivity, repeatability and recovery. A good linearity (R2=0.99) was found in the concentration range of 0.31–5.0mgl−1 in milk with a limit of detection of 0.17mgl−1. This method does not require a long extraction procedure (total analysis time can be lower than 30min) and can be reliably used for melamine detection in milk matrix in accordance with the European law limits.</description><identifier>ISSN: 0308-8146</identifier><identifier>EISSN: 1873-7072</identifier><identifier>DOI: 10.1016/j.foodchem.2014.03.013</identifier><identifier>PMID: 24767052</identifier><identifier>CODEN: FOCHDJ</identifier><language>eng</language><publisher>Kidlington: Elsevier Ltd</publisher><subject>Adsorption ; Analytical chemistry ; Animals ; Biological and medical sciences ; Chemical and industrial products toxicology. Toxic occupational diseases ; Food Contamination - analysis ; Food toxicology ; Gold ; Gold - chemistry ; Gold nanoparticles ; Linearity ; Medical sciences ; Melamine ; Metal Nanoparticles - chemistry ; Metals and various inorganic compounds ; Milk ; Milk - chemistry ; Nanoparticles ; Quantitative analysis ; Raman scattering ; Raman spectroscopy ; Sensitivity and Specificity ; SERS ; Spectrum Analysis, Raman - instrumentation ; Spectrum Analysis, Raman - methods ; Toxicology ; Triazines - analysis</subject><ispartof>Food chemistry, 2014-09, Vol.159, p.250-256</ispartof><rights>2014 Elsevier Ltd</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2014 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c464t-8e6df439f7aee5e6a173d515d412e8bc0710f652bd9adcc6467fb6aa3358aad43</citedby><cites>FETCH-LOGICAL-c464t-8e6df439f7aee5e6a173d515d412e8bc0710f652bd9adcc6467fb6aa3358aad43</cites><orcidid>0000-0003-2575-0337</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0308814614003987$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28417409$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24767052$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Giovannozzi, Andrea Mario</creatorcontrib><creatorcontrib>Rolle, Francesca</creatorcontrib><creatorcontrib>Sega, Michela</creatorcontrib><creatorcontrib>Abete, Maria Cesarina</creatorcontrib><creatorcontrib>Marchis, Daniela</creatorcontrib><creatorcontrib>Rossi, Andrea Mario</creatorcontrib><title>Rapid and sensitive detection of melamine in milk with gold nanoparticles by Surface Enhanced Raman Scattering</title><title>Food chemistry</title><addtitle>Food Chem</addtitle><description>•We present a rapid and sensitive method to detect melamine in milk based on SERS.•Interaction of melamine with AuNPs enhances melamine Raman signal in the analysis.•Different size AuNPs were tested to achieve the highest SERS enhancement.•Melamine detection in milk is in accordance with the European law limits.•SERS analysis is validated for sensitivity, linearity, recovery and repeatability.
A rapid and sensitive method to detect melamine in liquid milk based on Surface Enhanced Raman Scattering (SERS) spectroscopy is presented, exploiting the selective binding of gold nanoparticles (AuNPs) with this analyte. This interaction promotes the aggregation of the AuNPs inducing a huge enhancement of the melamine signals in the Raman spectrum due to the formation of SERS “hot spots”. An external standard calibration method was employed for quantitative analysis and the method was validated for linearity, sensitivity, repeatability and recovery. A good linearity (R2=0.99) was found in the concentration range of 0.31–5.0mgl−1 in milk with a limit of detection of 0.17mgl−1. This method does not require a long extraction procedure (total analysis time can be lower than 30min) and can be reliably used for melamine detection in milk matrix in accordance with the European law limits.</description><subject>Adsorption</subject><subject>Analytical chemistry</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Chemical and industrial products toxicology. Toxic occupational diseases</subject><subject>Food Contamination - analysis</subject><subject>Food toxicology</subject><subject>Gold</subject><subject>Gold - chemistry</subject><subject>Gold nanoparticles</subject><subject>Linearity</subject><subject>Medical sciences</subject><subject>Melamine</subject><subject>Metal Nanoparticles - chemistry</subject><subject>Metals and various inorganic compounds</subject><subject>Milk</subject><subject>Milk - chemistry</subject><subject>Nanoparticles</subject><subject>Quantitative analysis</subject><subject>Raman scattering</subject><subject>Raman spectroscopy</subject><subject>Sensitivity and Specificity</subject><subject>SERS</subject><subject>Spectrum Analysis, Raman - instrumentation</subject><subject>Spectrum Analysis, Raman - methods</subject><subject>Toxicology</subject><subject>Triazines - analysis</subject><issn>0308-8146</issn><issn>1873-7072</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqN0ctu1DAUgOEIgehQeIXKGyQ2CXZ8nR2oKhepElILa-vEPu54SJzBzhT17fFoprAsK2--Yx_5b5oLRjtGmXq_7cI8e7fBqespEx3lHWX8WbNiRvNWU90_b1aUU9MaJtRZ86qULaW0WvOyOeuFVprKftWkG9hFTyB5UjCVuMR7JB4XdEucE5kDmXCEKSYkMZEpjj_J77hsyN08epIgzTvIS3QjFjI8kNt9DuCQXKUNJIee3MAEidw6WBbMMd29bl4EGAu-OZ3nzY9PV98vv7TX3z5_vfx43TqhxNIaVD4Ivg4aECUqYJp7yaQXrEczOKoZDUr2g1-Dd04JpcOgADiXBsALft68O967y_OvPZbFTrE4HEdIOO-LZVpyyYwS_GkqJaNSC0n_g7K1EUysTaXqSF2eS8kY7C7HCfKDZdQeCtqtfSxoDwUt5bYWrIMXpzf2w4T-79hjsgrengAUB2PI9adj-efqAlrQdXUfjg7rP99HzLa4iIcqMde61s_xqV3-APaSvVk</recordid><startdate>20140915</startdate><enddate>20140915</enddate><creator>Giovannozzi, Andrea Mario</creator><creator>Rolle, Francesca</creator><creator>Sega, Michela</creator><creator>Abete, Maria Cesarina</creator><creator>Marchis, Daniela</creator><creator>Rossi, Andrea Mario</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7U7</scope><scope>C1K</scope><scope>7QQ</scope><scope>7U5</scope><scope>8FD</scope><scope>F28</scope><scope>FR3</scope><scope>JG9</scope><scope>L7M</scope><orcidid>https://orcid.org/0000-0003-2575-0337</orcidid></search><sort><creationdate>20140915</creationdate><title>Rapid and sensitive detection of melamine in milk with gold nanoparticles by Surface Enhanced Raman Scattering</title><author>Giovannozzi, Andrea Mario ; Rolle, Francesca ; Sega, Michela ; Abete, Maria Cesarina ; Marchis, Daniela ; Rossi, Andrea Mario</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c464t-8e6df439f7aee5e6a173d515d412e8bc0710f652bd9adcc6467fb6aa3358aad43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adsorption</topic><topic>Analytical chemistry</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Chemical and industrial products toxicology. Toxic occupational diseases</topic><topic>Food Contamination - analysis</topic><topic>Food toxicology</topic><topic>Gold</topic><topic>Gold - chemistry</topic><topic>Gold nanoparticles</topic><topic>Linearity</topic><topic>Medical sciences</topic><topic>Melamine</topic><topic>Metal Nanoparticles - chemistry</topic><topic>Metals and various inorganic compounds</topic><topic>Milk</topic><topic>Milk - chemistry</topic><topic>Nanoparticles</topic><topic>Quantitative analysis</topic><topic>Raman scattering</topic><topic>Raman spectroscopy</topic><topic>Sensitivity and Specificity</topic><topic>SERS</topic><topic>Spectrum Analysis, Raman - instrumentation</topic><topic>Spectrum Analysis, Raman - methods</topic><topic>Toxicology</topic><topic>Triazines - analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Giovannozzi, Andrea Mario</creatorcontrib><creatorcontrib>Rolle, Francesca</creatorcontrib><creatorcontrib>Sega, Michela</creatorcontrib><creatorcontrib>Abete, Maria Cesarina</creatorcontrib><creatorcontrib>Marchis, Daniela</creatorcontrib><creatorcontrib>Rossi, Andrea Mario</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Ceramic Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Technology Research Database</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>Food chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Giovannozzi, Andrea Mario</au><au>Rolle, Francesca</au><au>Sega, Michela</au><au>Abete, Maria Cesarina</au><au>Marchis, Daniela</au><au>Rossi, Andrea Mario</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Rapid and sensitive detection of melamine in milk with gold nanoparticles by Surface Enhanced Raman Scattering</atitle><jtitle>Food chemistry</jtitle><addtitle>Food Chem</addtitle><date>2014-09-15</date><risdate>2014</risdate><volume>159</volume><spage>250</spage><epage>256</epage><pages>250-256</pages><issn>0308-8146</issn><eissn>1873-7072</eissn><coden>FOCHDJ</coden><abstract>•We present a rapid and sensitive method to detect melamine in milk based on SERS.•Interaction of melamine with AuNPs enhances melamine Raman signal in the analysis.•Different size AuNPs were tested to achieve the highest SERS enhancement.•Melamine detection in milk is in accordance with the European law limits.•SERS analysis is validated for sensitivity, linearity, recovery and repeatability.
A rapid and sensitive method to detect melamine in liquid milk based on Surface Enhanced Raman Scattering (SERS) spectroscopy is presented, exploiting the selective binding of gold nanoparticles (AuNPs) with this analyte. This interaction promotes the aggregation of the AuNPs inducing a huge enhancement of the melamine signals in the Raman spectrum due to the formation of SERS “hot spots”. An external standard calibration method was employed for quantitative analysis and the method was validated for linearity, sensitivity, repeatability and recovery. A good linearity (R2=0.99) was found in the concentration range of 0.31–5.0mgl−1 in milk with a limit of detection of 0.17mgl−1. This method does not require a long extraction procedure (total analysis time can be lower than 30min) and can be reliably used for melamine detection in milk matrix in accordance with the European law limits.</abstract><cop>Kidlington</cop><pub>Elsevier Ltd</pub><pmid>24767052</pmid><doi>10.1016/j.foodchem.2014.03.013</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0003-2575-0337</orcidid></addata></record> |
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| subjects | Adsorption Analytical chemistry Animals Biological and medical sciences Chemical and industrial products toxicology. Toxic occupational diseases Food Contamination - analysis Food toxicology Gold Gold - chemistry Gold nanoparticles Linearity Medical sciences Melamine Metal Nanoparticles - chemistry Metals and various inorganic compounds Milk Milk - chemistry Nanoparticles Quantitative analysis Raman scattering Raman spectroscopy Sensitivity and Specificity SERS Spectrum Analysis, Raman - instrumentation Spectrum Analysis, Raman - methods Toxicology Triazines - analysis |
| title | Rapid and sensitive detection of melamine in milk with gold nanoparticles by Surface Enhanced Raman Scattering |
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