Normal aging in rats and pathological aging in human Alzheimer’s disease decrease FAAH activity: Modulation by cannabinoid agonists

Anandamide is an endocannabinoid involved in several physiological functions including neuroprotection. Anandamide is synthesized on demand and its endogenous level is regulated through its degradation, where fatty acid amide hydrolase plays a major role. The aim of this study was to characterize an...

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Veröffentlicht in:	Experimental gerontology 2014-12, Vol.60, p.92-99
Hauptverfasser:	Pascual, A.C., Martín-Moreno, A.M., Giusto, N.M., de Ceballos, M.L., Pasquaré, S.J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Aging Aging - metabolism Alzheimer Disease - drug therapy Alzheimer Disease - metabolism Alzheimer's disease Amidohydrolases - antagonists & inhibitors Amidohydrolases - metabolism Amyloid beta-Peptides - metabolism Anandamide Animals Arachidonic Acids - metabolism Benzamides - pharmacology Benzoxazines - pharmacology Cannabinoid Receptor Agonists - pharmacology Cannabinoid receptors Cannabinoids - pharmacology Carbamates - pharmacology Case-Control Studies Central nervous system Cerebral Cortex - drug effects Cerebral Cortex - metabolism Endocannabinoids - metabolism Enzyme Inhibitors - pharmacology Fatty acid amide hydrolase Female Frontal Lobe - drug effects Frontal Lobe - metabolism Humans In Vitro Techniques Male Middle Aged Morpholines - pharmacology Naphthalenes - pharmacology Polyunsaturated Alkamides - metabolism Rats Rats, Wistar Synaptosomes - drug effects Synaptosomes - metabolism
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