Effect of intense pulsed light on the expression of aquaporin 3 in rat skin
Intense pulsed light (IPL) technology has been popularly employed in clinical treatments for dermatological and cosmetic purposes in recent years; yet, the underlying mechanisms of its functions are not fully elucidated. On the other hand, aquaporin (AQP) 3, a member of a subgroup of the aquaporin f...
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| Veröffentlicht in: | Lasers in medical science 2015-09, Vol.30 (7), p.1959-1965 |
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| creator | Wu, Cheng-Jung Chen, Chien-Chung Shih, Hsiang-Shun Chang, Li-Ren Liu, Chih-Hsin Liu, Yi-Tien Lin, Pin-Hsuan Huang, Wen-Shyan Jeng, Seng-Feng Feng, Guan-Ming |
| description | Intense pulsed light (IPL) technology has been popularly employed in clinical treatments for dermatological and cosmetic purposes in recent years; yet, the underlying mechanisms of its functions are not fully elucidated. On the other hand, aquaporin (AQP) 3, a member of a subgroup of the aquaporin family that transports both water and small solutes, such as glycerol, has been documented to play an important role in the skin homeostasis. We thus examined the possible involvement of AQP3 in the functional mechanisms of IPL irradiation. Rat dorsal skin areas were irradiated one to three times with IPL at doses of 15, 25, and 35 J/cm2. Skin specimens were collected 7 days after the final irradiation and analyzed for changes in histology, skin hydration, mRNA, and protein expressions of AQP3. IPL induced no significant variations in the mRNA expression levels. Twice or thrice irradiation at the dose of 25 or 35 J/cm2 significantly enhanced AQP3 protein expression. Immunofluorescence study revealed that AQP3 was mainly localized to keratinocyte membranes in the basal layer of epidermis, and the localization was unaltered by IPL. In addition, the pattern of IPL-induced changes in skin hydration was generally coincided with the expression profile of AQP3. These results suggest the possibility that one of the functional mechanisms of IPL might be related to the regulation of AQP3 protein expression. |
| doi_str_mv | 10.1007/s10103-015-1788-4 |
| format | Article |
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On the other hand, aquaporin (AQP) 3, a member of a subgroup of the aquaporin family that transports both water and small solutes, such as glycerol, has been documented to play an important role in the skin homeostasis. We thus examined the possible involvement of AQP3 in the functional mechanisms of IPL irradiation. Rat dorsal skin areas were irradiated one to three times with IPL at doses of 15, 25, and 35 J/cm2. Skin specimens were collected 7 days after the final irradiation and analyzed for changes in histology, skin hydration, mRNA, and protein expressions of AQP3. IPL induced no significant variations in the mRNA expression levels. Twice or thrice irradiation at the dose of 25 or 35 J/cm2 significantly enhanced AQP3 protein expression. Immunofluorescence study revealed that AQP3 was mainly localized to keratinocyte membranes in the basal layer of epidermis, and the localization was unaltered by IPL. In addition, the pattern of IPL-induced changes in skin hydration was generally coincided with the expression profile of AQP3. These results suggest the possibility that one of the functional mechanisms of IPL might be related to the regulation of AQP3 protein expression.</description><identifier>ISSN: 0268-8921</identifier><identifier>EISSN: 1435-604X</identifier><identifier>DOI: 10.1007/s10103-015-1788-4</identifier><identifier>PMID: 26231231</identifier><identifier>CODEN: LMSCEZ</identifier><language>eng</language><publisher>London: Springer London</publisher><subject>Animals ; Aquaporin 3 - genetics ; Aquaporin 3 - metabolism ; Cosmetics ; Dentistry ; Dermatology ; Gene expression ; Gene Expression - radiation effects ; Hydration ; Intense Pulsed Light Therapy ; Irradiation ; Keratinocytes - metabolism ; Keratinocytes - radiation effects ; Lasers ; Male ; Medical science ; Medical services ; Medicine ; Medicine & Public Health ; Optical Devices ; Optics ; Original Article ; Photonics ; Position (location) ; Protein expression ; Proteins ; Quantum Optics ; Rats ; Rats, Sprague-Dawley ; RNA, Messenger - metabolism ; Rodents ; Skin ; Skin - cytology ; Skin - metabolism ; Skin - radiation effects</subject><ispartof>Lasers in medical science, 2015-09, Vol.30 (7), p.1959-1965</ispartof><rights>Springer-Verlag London 2015</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c508t-7a122678089837ac1a8fc0dc1449708ef101bd7a7a973168b69690054fd7c85d3</citedby><cites>FETCH-LOGICAL-c508t-7a122678089837ac1a8fc0dc1449708ef101bd7a7a973168b69690054fd7c85d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10103-015-1788-4$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10103-015-1788-4$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>315,781,785,27926,27927,41490,42559,51321</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26231231$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wu, Cheng-Jung</creatorcontrib><creatorcontrib>Chen, Chien-Chung</creatorcontrib><creatorcontrib>Shih, Hsiang-Shun</creatorcontrib><creatorcontrib>Chang, Li-Ren</creatorcontrib><creatorcontrib>Liu, Chih-Hsin</creatorcontrib><creatorcontrib>Liu, Yi-Tien</creatorcontrib><creatorcontrib>Lin, Pin-Hsuan</creatorcontrib><creatorcontrib>Huang, Wen-Shyan</creatorcontrib><creatorcontrib>Jeng, Seng-Feng</creatorcontrib><creatorcontrib>Feng, Guan-Ming</creatorcontrib><title>Effect of intense pulsed light on the expression of aquaporin 3 in rat skin</title><title>Lasers in medical science</title><addtitle>Lasers Med Sci</addtitle><addtitle>Lasers Med Sci</addtitle><description>Intense pulsed light (IPL) technology has been popularly employed in clinical treatments for dermatological and cosmetic purposes in recent years; yet, the underlying mechanisms of its functions are not fully elucidated. On the other hand, aquaporin (AQP) 3, a member of a subgroup of the aquaporin family that transports both water and small solutes, such as glycerol, has been documented to play an important role in the skin homeostasis. We thus examined the possible involvement of AQP3 in the functional mechanisms of IPL irradiation. Rat dorsal skin areas were irradiated one to three times with IPL at doses of 15, 25, and 35 J/cm2. Skin specimens were collected 7 days after the final irradiation and analyzed for changes in histology, skin hydration, mRNA, and protein expressions of AQP3. IPL induced no significant variations in the mRNA expression levels. Twice or thrice irradiation at the dose of 25 or 35 J/cm2 significantly enhanced AQP3 protein expression. Immunofluorescence study revealed that AQP3 was mainly localized to keratinocyte membranes in the basal layer of epidermis, and the localization was unaltered by IPL. In addition, the pattern of IPL-induced changes in skin hydration was generally coincided with the expression profile of AQP3. These results suggest the possibility that one of the functional mechanisms of IPL might be related to the regulation of AQP3 protein expression.</description><subject>Animals</subject><subject>Aquaporin 3 - genetics</subject><subject>Aquaporin 3 - metabolism</subject><subject>Cosmetics</subject><subject>Dentistry</subject><subject>Dermatology</subject><subject>Gene expression</subject><subject>Gene Expression - radiation effects</subject><subject>Hydration</subject><subject>Intense Pulsed Light Therapy</subject><subject>Irradiation</subject><subject>Keratinocytes - metabolism</subject><subject>Keratinocytes - radiation effects</subject><subject>Lasers</subject><subject>Male</subject><subject>Medical science</subject><subject>Medical services</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Optical Devices</subject><subject>Optics</subject><subject>Original Article</subject><subject>Photonics</subject><subject>Position (location)</subject><subject>Protein expression</subject><subject>Proteins</subject><subject>Quantum Optics</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>RNA, Messenger - metabolism</subject><subject>Rodents</subject><subject>Skin</subject><subject>Skin - cytology</subject><subject>Skin - metabolism</subject><subject>Skin - radiation effects</subject><issn>0268-8921</issn><issn>1435-604X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNkUtLxDAUhYMoOj5-gBsJuHFTvTdpk3Qp4gsFNwruQqZNnY4zbU1a0H_v1aqIIAqBkOQ753JyGNtFOEQAfRQREGQCmCWojUnSFTbBVGaJgvR-lU1AKJOYXOAG24xxDoBaoVxnG0IJibQm7Oq0qnzR87biddP7JnreDYvoS76oH2Z03_B-5rl_7oKPsaYjke5pcF0b6oZLUvHgeh4f62abrVWOtDsf-xa7Ozu9PblIrm_OL0-Or5MiA9Mn2qEQShswuZHaFehMVUBZYJrmGoyvKNW01E67XEtUZqpylQNkaVXqwmSl3GIHo28X2qfBx94u61j4xcI1vh2iRZ3JDFNDCf9GhaCvy0T-DxQhN-QMhO7_QOftEBrK_E7RaGEUUThSRWhjDL6yXaiXLrxYBPvWnx37s9SffevPpqTZ-3Aepktffik-CyNAjECkp-bBh2-jf3V9BbcvoZM</recordid><startdate>20150901</startdate><enddate>20150901</enddate><creator>Wu, Cheng-Jung</creator><creator>Chen, Chien-Chung</creator><creator>Shih, Hsiang-Shun</creator><creator>Chang, Li-Ren</creator><creator>Liu, Chih-Hsin</creator><creator>Liu, Yi-Tien</creator><creator>Lin, Pin-Hsuan</creator><creator>Huang, Wen-Shyan</creator><creator>Jeng, Seng-Feng</creator><creator>Feng, Guan-Ming</creator><general>Springer London</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7RV</scope><scope>7SP</scope><scope>7U5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H8D</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>L7M</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>20150901</creationdate><title>Effect of intense pulsed light on the expression of aquaporin 3 in rat skin</title><author>Wu, Cheng-Jung ; Chen, Chien-Chung ; Shih, Hsiang-Shun ; Chang, Li-Ren ; Liu, Chih-Hsin ; Liu, Yi-Tien ; Lin, Pin-Hsuan ; Huang, Wen-Shyan ; Jeng, Seng-Feng ; Feng, Guan-Ming</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c508t-7a122678089837ac1a8fc0dc1449708ef101bd7a7a973168b69690054fd7c85d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Animals</topic><topic>Aquaporin 3 - 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Academic</collection><jtitle>Lasers in medical science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wu, Cheng-Jung</au><au>Chen, Chien-Chung</au><au>Shih, Hsiang-Shun</au><au>Chang, Li-Ren</au><au>Liu, Chih-Hsin</au><au>Liu, Yi-Tien</au><au>Lin, Pin-Hsuan</au><au>Huang, Wen-Shyan</au><au>Jeng, Seng-Feng</au><au>Feng, Guan-Ming</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of intense pulsed light on the expression of aquaporin 3 in rat skin</atitle><jtitle>Lasers in medical science</jtitle><stitle>Lasers Med Sci</stitle><addtitle>Lasers Med Sci</addtitle><date>2015-09-01</date><risdate>2015</risdate><volume>30</volume><issue>7</issue><spage>1959</spage><epage>1965</epage><pages>1959-1965</pages><issn>0268-8921</issn><eissn>1435-604X</eissn><coden>LMSCEZ</coden><abstract>Intense pulsed light (IPL) technology has been popularly employed in clinical treatments for dermatological and cosmetic purposes in recent years; yet, the underlying mechanisms of its functions are not fully elucidated. On the other hand, aquaporin (AQP) 3, a member of a subgroup of the aquaporin family that transports both water and small solutes, such as glycerol, has been documented to play an important role in the skin homeostasis. We thus examined the possible involvement of AQP3 in the functional mechanisms of IPL irradiation. Rat dorsal skin areas were irradiated one to three times with IPL at doses of 15, 25, and 35 J/cm2. Skin specimens were collected 7 days after the final irradiation and analyzed for changes in histology, skin hydration, mRNA, and protein expressions of AQP3. IPL induced no significant variations in the mRNA expression levels. Twice or thrice irradiation at the dose of 25 or 35 J/cm2 significantly enhanced AQP3 protein expression. Immunofluorescence study revealed that AQP3 was mainly localized to keratinocyte membranes in the basal layer of epidermis, and the localization was unaltered by IPL. In addition, the pattern of IPL-induced changes in skin hydration was generally coincided with the expression profile of AQP3. These results suggest the possibility that one of the functional mechanisms of IPL might be related to the regulation of AQP3 protein expression.</abstract><cop>London</cop><pub>Springer London</pub><pmid>26231231</pmid><doi>10.1007/s10103-015-1788-4</doi><tpages>7</tpages></addata></record> |
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| subjects | Animals Aquaporin 3 - genetics Aquaporin 3 - metabolism Cosmetics Dentistry Dermatology Gene expression Gene Expression - radiation effects Hydration Intense Pulsed Light Therapy Irradiation Keratinocytes - metabolism Keratinocytes - radiation effects Lasers Male Medical science Medical services Medicine Medicine & Public Health Optical Devices Optics Original Article Photonics Position (location) Protein expression Proteins Quantum Optics Rats Rats, Sprague-Dawley RNA, Messenger - metabolism Rodents Skin Skin - cytology Skin - metabolism Skin - radiation effects |
| title | Effect of intense pulsed light on the expression of aquaporin 3 in rat skin |
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