Amphiphilic chitosan derivative-based core–shell micelles: Synthesis, characterisation and properties for sustained release of Vitamin D3
•A novel amphiphilic chitosan derivative (DCMCs) with hydrophilic carboxyl and hydrophobic hexadecyl groups was synthesised.•DCMCs can form core–shell micelles by self-assemble in water solution with low critical micelle concentration.•Vitamin D3 was initially applied to load into DCMCs core–shell m...
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| Veröffentlicht in: | Food chemistry 2014-06, Vol.152, p.307-315 |
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| creator | Li, Wenjian Peng, Hailong Ning, Fangjian Yao, Lihua Luo, Mei Zhao, Qiang Zhu, Xuemei Xiong, Hua |
| description | •A novel amphiphilic chitosan derivative (DCMCs) with hydrophilic carboxyl and hydrophobic hexadecyl groups was synthesised.•DCMCs can form core–shell micelles by self-assemble in water solution with low critical micelle concentration.•Vitamin D3 was initially applied to load into DCMCs core–shell micelles.•The solubility and stability of Vitamin D3 were improved greatly.
Novel amphiphilic chitosan derivative of N,N-dimethylhexadecyl carboxymethyl chitosan (DCMCs) was synthesised. The physical properties of DCMCs were characterised by Fourier transform-infrared spectroscopy, nuclear magnetic resonance spectroscopy, X-ray diffraction and differential scanning calorimetry. DCMCs can form core–shell micelles with low critical micelle concentration (31mgL−1). The core–shell micelles exhibited spherical shape with positive charge (+50.7mV) and narrow size distribution (polydispersity index |
| doi_str_mv | 10.1016/j.foodchem.2013.11.147 |
| format | Article |
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Novel amphiphilic chitosan derivative of N,N-dimethylhexadecyl carboxymethyl chitosan (DCMCs) was synthesised. The physical properties of DCMCs were characterised by Fourier transform-infrared spectroscopy, nuclear magnetic resonance spectroscopy, X-ray diffraction and differential scanning calorimetry. DCMCs can form core–shell micelles with low critical micelle concentration (31mgL−1). The core–shell micelles exhibited spherical shape with positive charge (+50.7mV) and narrow size distribution (polydispersity index <0.5). Vitamin D3 (VD3) was initially used to load into the core–shell micelles, and the solubility of VD3 was improved with higher encapsulation efficiency (53.2%). The in vitro release processes of VD3 from the core–shell micelles were initially rapid and then followed by a sustained release. The Higuchi model was the most suitable for describing the entire release procedure. DCMCs core–shell micelles are promising carriers for VD3 and other hydrophobic bioactive food factors.</description><identifier>ISSN: 0308-8146</identifier><identifier>EISSN: 1873-7072</identifier><identifier>DOI: 10.1016/j.foodchem.2013.11.147</identifier><identifier>PMID: 24444942</identifier><identifier>CODEN: FOCHDJ</identifier><language>eng</language><publisher>Kidlington: Elsevier Ltd</publisher><subject>Biological and medical sciences ; Charge ; Chitosan ; Chitosan - chemical synthesis ; Chitosan - chemistry ; Cholecalciferol - chemistry ; Core–shell micelle ; Delayed-Action Preparations - chemistry ; Drug Carriers - chemical synthesis ; Drug Carriers - chemistry ; Drug Delivery Systems ; Food toxicology ; Foods ; Hydrophobic and Hydrophilic Interactions ; Kinetics ; Mathematical models ; Medical sciences ; Micelles ; N,N-Dimethylhexadecyl carboxymethyl chitosan ; Particle Size ; Self-assemble ; Solubility ; Spectroscopy ; Sustained release ; Toxicology ; Vitamin D3 ; Vitamins ; X-Ray Diffraction</subject><ispartof>Food chemistry, 2014-06, Vol.152, p.307-315</ispartof><rights>2013 Elsevier Ltd</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2013 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c379t-f443aa04654928278d5f385cfe53e2c53e1bcea37d0e933cdb7d12b4143deeb73</citedby><cites>FETCH-LOGICAL-c379t-f443aa04654928278d5f385cfe53e2c53e1bcea37d0e933cdb7d12b4143deeb73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.foodchem.2013.11.147$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27929,27930,46000</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28351926$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24444942$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Wenjian</creatorcontrib><creatorcontrib>Peng, Hailong</creatorcontrib><creatorcontrib>Ning, Fangjian</creatorcontrib><creatorcontrib>Yao, Lihua</creatorcontrib><creatorcontrib>Luo, Mei</creatorcontrib><creatorcontrib>Zhao, Qiang</creatorcontrib><creatorcontrib>Zhu, Xuemei</creatorcontrib><creatorcontrib>Xiong, Hua</creatorcontrib><title>Amphiphilic chitosan derivative-based core–shell micelles: Synthesis, characterisation and properties for sustained release of Vitamin D3</title><title>Food chemistry</title><addtitle>Food Chem</addtitle><description>•A novel amphiphilic chitosan derivative (DCMCs) with hydrophilic carboxyl and hydrophobic hexadecyl groups was synthesised.•DCMCs can form core–shell micelles by self-assemble in water solution with low critical micelle concentration.•Vitamin D3 was initially applied to load into DCMCs core–shell micelles.•The solubility and stability of Vitamin D3 were improved greatly.
Novel amphiphilic chitosan derivative of N,N-dimethylhexadecyl carboxymethyl chitosan (DCMCs) was synthesised. The physical properties of DCMCs were characterised by Fourier transform-infrared spectroscopy, nuclear magnetic resonance spectroscopy, X-ray diffraction and differential scanning calorimetry. DCMCs can form core–shell micelles with low critical micelle concentration (31mgL−1). The core–shell micelles exhibited spherical shape with positive charge (+50.7mV) and narrow size distribution (polydispersity index <0.5). Vitamin D3 (VD3) was initially used to load into the core–shell micelles, and the solubility of VD3 was improved with higher encapsulation efficiency (53.2%). The in vitro release processes of VD3 from the core–shell micelles were initially rapid and then followed by a sustained release. The Higuchi model was the most suitable for describing the entire release procedure. DCMCs core–shell micelles are promising carriers for VD3 and other hydrophobic bioactive food factors.</description><subject>Biological and medical sciences</subject><subject>Charge</subject><subject>Chitosan</subject><subject>Chitosan - chemical synthesis</subject><subject>Chitosan - chemistry</subject><subject>Cholecalciferol - chemistry</subject><subject>Core–shell micelle</subject><subject>Delayed-Action Preparations - chemistry</subject><subject>Drug Carriers - chemical synthesis</subject><subject>Drug Carriers - chemistry</subject><subject>Drug Delivery Systems</subject><subject>Food toxicology</subject><subject>Foods</subject><subject>Hydrophobic and Hydrophilic Interactions</subject><subject>Kinetics</subject><subject>Mathematical models</subject><subject>Medical sciences</subject><subject>Micelles</subject><subject>N,N-Dimethylhexadecyl carboxymethyl chitosan</subject><subject>Particle Size</subject><subject>Self-assemble</subject><subject>Solubility</subject><subject>Spectroscopy</subject><subject>Sustained release</subject><subject>Toxicology</subject><subject>Vitamin D3</subject><subject>Vitamins</subject><subject>X-Ray Diffraction</subject><issn>0308-8146</issn><issn>1873-7072</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkcuO1DAQRS0EYpqBXxh5g8RiEvxKO2HFaHhKI7HgsbUcu6K4lcSNy93S7Niz5A_5EtzqHlgOluXanFt1y5eQC85qzvj65aYeYvRuhLkWjMua85or_YCseKtlpZkWD8mKSdZWLVfrM_IEccMYK2z7mJwJVU6nxIr8vJq3Yyh3Co66MeSIdqEeUtjbHPZQ9RbBUxcT_P7xC0eYJjoHVwrgK_r5dskjYMDLorXJulyEWIRxoXbxdJviFlIOgHSIieIOsw1L6ZdggtKYxoF-C9nOYaFv5FPyaLATwrNTPSdf3739cv2huvn0_uP11U3lpO5yNSglrWVq3ahOtEK3vhlk27gBGgnClYf3DqzUnkEnpfO99lz0iivpAXotz8mLY99i7_sOMJs54GElu0DcoeG6kQ3nnfoPtJGs60Qn-P1ocbtueVmhoOsj6lJETDCYbQqzTbeGM3OI12zMXbzmEK_hvOgPdi5OM3b9DP6v7C7PAjw_ARadnYZkFxfwH9eWxYqNwr0-clD-eR8gGXQBFgc-JHDZ-Bju8_IHoPbJtQ</recordid><startdate>20140601</startdate><enddate>20140601</enddate><creator>Li, Wenjian</creator><creator>Peng, Hailong</creator><creator>Ning, Fangjian</creator><creator>Yao, Lihua</creator><creator>Luo, Mei</creator><creator>Zhao, Qiang</creator><creator>Zhu, Xuemei</creator><creator>Xiong, Hua</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QQ</scope><scope>7U5</scope><scope>8FD</scope><scope>F28</scope><scope>FR3</scope><scope>JG9</scope><scope>L7M</scope></search><sort><creationdate>20140601</creationdate><title>Amphiphilic chitosan derivative-based core–shell micelles: Synthesis, characterisation and properties for sustained release of Vitamin D3</title><author>Li, Wenjian ; Peng, Hailong ; Ning, Fangjian ; Yao, Lihua ; Luo, Mei ; Zhao, Qiang ; Zhu, Xuemei ; Xiong, Hua</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c379t-f443aa04654928278d5f385cfe53e2c53e1bcea37d0e933cdb7d12b4143deeb73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Biological and medical sciences</topic><topic>Charge</topic><topic>Chitosan</topic><topic>Chitosan - chemical synthesis</topic><topic>Chitosan - chemistry</topic><topic>Cholecalciferol - chemistry</topic><topic>Core–shell micelle</topic><topic>Delayed-Action Preparations - chemistry</topic><topic>Drug Carriers - chemical synthesis</topic><topic>Drug Carriers - chemistry</topic><topic>Drug Delivery Systems</topic><topic>Food toxicology</topic><topic>Foods</topic><topic>Hydrophobic and Hydrophilic Interactions</topic><topic>Kinetics</topic><topic>Mathematical models</topic><topic>Medical sciences</topic><topic>Micelles</topic><topic>N,N-Dimethylhexadecyl carboxymethyl chitosan</topic><topic>Particle Size</topic><topic>Self-assemble</topic><topic>Solubility</topic><topic>Spectroscopy</topic><topic>Sustained release</topic><topic>Toxicology</topic><topic>Vitamin D3</topic><topic>Vitamins</topic><topic>X-Ray Diffraction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Wenjian</creatorcontrib><creatorcontrib>Peng, Hailong</creatorcontrib><creatorcontrib>Ning, Fangjian</creatorcontrib><creatorcontrib>Yao, Lihua</creatorcontrib><creatorcontrib>Luo, Mei</creatorcontrib><creatorcontrib>Zhao, Qiang</creatorcontrib><creatorcontrib>Zhu, Xuemei</creatorcontrib><creatorcontrib>Xiong, Hua</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Ceramic Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Technology Research Database</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>Food chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Wenjian</au><au>Peng, Hailong</au><au>Ning, Fangjian</au><au>Yao, Lihua</au><au>Luo, Mei</au><au>Zhao, Qiang</au><au>Zhu, Xuemei</au><au>Xiong, Hua</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Amphiphilic chitosan derivative-based core–shell micelles: Synthesis, characterisation and properties for sustained release of Vitamin D3</atitle><jtitle>Food chemistry</jtitle><addtitle>Food Chem</addtitle><date>2014-06-01</date><risdate>2014</risdate><volume>152</volume><spage>307</spage><epage>315</epage><pages>307-315</pages><issn>0308-8146</issn><eissn>1873-7072</eissn><coden>FOCHDJ</coden><abstract>•A novel amphiphilic chitosan derivative (DCMCs) with hydrophilic carboxyl and hydrophobic hexadecyl groups was synthesised.•DCMCs can form core–shell micelles by self-assemble in water solution with low critical micelle concentration.•Vitamin D3 was initially applied to load into DCMCs core–shell micelles.•The solubility and stability of Vitamin D3 were improved greatly.
Novel amphiphilic chitosan derivative of N,N-dimethylhexadecyl carboxymethyl chitosan (DCMCs) was synthesised. The physical properties of DCMCs were characterised by Fourier transform-infrared spectroscopy, nuclear magnetic resonance spectroscopy, X-ray diffraction and differential scanning calorimetry. DCMCs can form core–shell micelles with low critical micelle concentration (31mgL−1). The core–shell micelles exhibited spherical shape with positive charge (+50.7mV) and narrow size distribution (polydispersity index <0.5). Vitamin D3 (VD3) was initially used to load into the core–shell micelles, and the solubility of VD3 was improved with higher encapsulation efficiency (53.2%). The in vitro release processes of VD3 from the core–shell micelles were initially rapid and then followed by a sustained release. The Higuchi model was the most suitable for describing the entire release procedure. DCMCs core–shell micelles are promising carriers for VD3 and other hydrophobic bioactive food factors.</abstract><cop>Kidlington</cop><pub>Elsevier Ltd</pub><pmid>24444942</pmid><doi>10.1016/j.foodchem.2013.11.147</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0308-8146 |
| ispartof | Food chemistry, 2014-06, Vol.152, p.307-315 |
| issn | 0308-8146 1873-7072 |
| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Biological and medical sciences Charge Chitosan Chitosan - chemical synthesis Chitosan - chemistry Cholecalciferol - chemistry Core–shell micelle Delayed-Action Preparations - chemistry Drug Carriers - chemical synthesis Drug Carriers - chemistry Drug Delivery Systems Food toxicology Foods Hydrophobic and Hydrophilic Interactions Kinetics Mathematical models Medical sciences Micelles N,N-Dimethylhexadecyl carboxymethyl chitosan Particle Size Self-assemble Solubility Spectroscopy Sustained release Toxicology Vitamin D3 Vitamins X-Ray Diffraction |
| title | Amphiphilic chitosan derivative-based core–shell micelles: Synthesis, characterisation and properties for sustained release of Vitamin D3 |
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