Tamoxifen induces endometrial and vaginal cancer in rats in the absence of endometrial hyperplasia

Tamoxifen was administered orally to neonatal rats on days 2–5 after birth and the subsequent effects on the uterus were characterized, morphometrically, over the following 12 months. Tamoxifen inhibited development of the uterus and glands in the endometrium, indicating a classical oestrogen antago...

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Veröffentlicht in:	Carcinogenesis (New York) 2000-04, Vol.21 (4), p.793-797
Hauptverfasser:	Carthew, Philip, Edwards, Richard E., Nolan, Barbara M., Martin, Elizabeth A., Heydon, Robert T., White, Ian N.H., Tucker, Mary J.
Format:	Artikel
Sprache:	eng
Schlagworte:	10% neutral buffered formalin Animals Animals, Newborn Antineoplastic Agents, Hormonal - toxicity Biological and medical sciences Body Weight - drug effects DES diethylstilbestrol DNA Adducts - analysis Drug toxicity and drugs side effects treatment Endometrial Hyperplasia - chemically induced Endometrial Neoplasms - chemically induced Female Female genital diseases Gynecology. Andrology. Obstetrics Medical sciences NBF oestrogen receptor Organ Size - drug effects Pharmacology. Drug treatments Rats Rats, Wistar tamoxifen Tamoxifen - toxicity Toxicity: urogenital system Tumors Vaginal Neoplasms - chemically induced
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