GABAergic neurotransmission and retinal ganglion cell function
Ganglion cells are the output retinal neurons that convey visual information to the brain. There are ~20 different types of ganglion cells, each encoding a specific aspect of the visual scene as spatial and temporal contrast, orientation, direction of movement, presence of looming stimuli; etc. Gang...
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| Veröffentlicht in: | Journal of Comparative Physiology 2015-03, Vol.201 (3), p.261-283 |
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| description | Ganglion cells are the output retinal neurons that convey visual information to the brain. There are ~20 different types of ganglion cells, each encoding a specific aspect of the visual scene as spatial and temporal contrast, orientation, direction of movement, presence of looming stimuli; etc. Ganglion cell functioning depends on the intrinsic properties of ganglion cell’s membrane as well as on the excitatory and inhibitory inputs that these cells receive from other retinal neurons. GABA is one of the most abundant inhibitory neurotransmitters in the retina. How it modulates the activity of different types of ganglion cells and what is its significance in extracting the basic features from visual scene are questions with fundamental importance in visual neuroscience. The present review summarizes current data concerning the types of membrane receptors that mediate GABA action in proximal retina; the effects of GABA and its antagonists on the ganglion cell light-evoked postsynaptic potentials and spike discharges; the action of GABAergic agents on centre-surround organization of the receptive fields and feature related ganglion cell activity. Special emphasis is put on the GABA action regarding the ON–OFF and sustained–transient ganglion cell dichotomy in both nonmammalian and mammalian retina. |
| doi_str_mv | 10.1007/s00359-015-0981-z |
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There are ~20 different types of ganglion cells, each encoding a specific aspect of the visual scene as spatial and temporal contrast, orientation, direction of movement, presence of looming stimuli; etc. Ganglion cell functioning depends on the intrinsic properties of ganglion cell’s membrane as well as on the excitatory and inhibitory inputs that these cells receive from other retinal neurons. GABA is one of the most abundant inhibitory neurotransmitters in the retina. How it modulates the activity of different types of ganglion cells and what is its significance in extracting the basic features from visual scene are questions with fundamental importance in visual neuroscience. The present review summarizes current data concerning the types of membrane receptors that mediate GABA action in proximal retina; the effects of GABA and its antagonists on the ganglion cell light-evoked postsynaptic potentials and spike discharges; the action of GABAergic agents on centre-surround organization of the receptive fields and feature related ganglion cell activity. 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There are ~20 different types of ganglion cells, each encoding a specific aspect of the visual scene as spatial and temporal contrast, orientation, direction of movement, presence of looming stimuli; etc. Ganglion cell functioning depends on the intrinsic properties of ganglion cell’s membrane as well as on the excitatory and inhibitory inputs that these cells receive from other retinal neurons. GABA is one of the most abundant inhibitory neurotransmitters in the retina. How it modulates the activity of different types of ganglion cells and what is its significance in extracting the basic features from visual scene are questions with fundamental importance in visual neuroscience. The present review summarizes current data concerning the types of membrane receptors that mediate GABA action in proximal retina; the effects of GABA and its antagonists on the ganglion cell light-evoked postsynaptic potentials and spike discharges; the action of GABAergic agents on centre-surround organization of the receptive fields and feature related ganglion cell activity. Special emphasis is put on the GABA action regarding the ON–OFF and sustained–transient ganglion cell dichotomy in both nonmammalian and mammalian retina.</description><subject>Animal Physiology</subject><subject>Animals</subject><subject>antagonists</subject><subject>Biomedical and Life Sciences</subject><subject>brain</subject><subject>GABA Antagonists - pharmacology</subject><subject>GABAergic Neurons - drug effects</subject><subject>GABAergic Neurons - metabolism</subject><subject>gamma-aminobutyric acid</subject><subject>gamma-Aminobutyric Acid - metabolism</subject><subject>ganglia</subject><subject>Humans</subject><subject>Life Sciences</subject><subject>Light</subject><subject>Light Signal Transduction</subject><subject>mammals</subject><subject>neurons</subject><subject>Neurosciences</subject><subject>neurotransmitters</subject><subject>Photic Stimulation</subject><subject>physiology</subject><subject>receptors</subject><subject>Receptors, GABA - metabolism</subject><subject>retina</subject><subject>Retinal Ganglion Cells - drug effects</subject><subject>Retinal Ganglion Cells - metabolism</subject><subject>Review</subject><subject>Synaptic Potentials</subject><subject>Synaptic Transmission - drug effects</subject><subject>Zoology</subject><issn>0340-7594</issn><issn>1432-1351</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNkUtPxCAUhYnR6Pj4AW60iRs31XuhFNiYjBNfiYkLdU2YljY1HarQLvTXS60a48K4IAT4zuHAIWQf4QQBxGkAYFylgDwFJTF9WyMzzBhNkXFcJzNgGaSCq2yLbIfwBAAUKW6SLcpznkuEGTm7mp_Pra-bInF28F3vjQurJoSmc4lxZeJt3zjTJrVxdTtuFrZtk2pwRR9Xu2SjMm2we5_zDnm8vHhYXKe3d1c3i_ltWmRK9WnGRCWsyAzmRWUQGaWiNMWyxJJVlFHBpZI5Q8oliiVWgllbsiWV1BpeWsl2yPHk--y7l8GGXseMYxLjbDcEjYIzDkrxf6A5FwwlCBbRo1_oUzf4-NoPKh_TZCpSOFGF70LwttLPvlkZ_6oR9NiDnnrQsQc99qDfoubg03lYrmz5rfj6-AjQCQjxyNXW_7j6D9fDSVSZTpvaN0E_3tMIQBwyV4K9A7uumpY</recordid><startdate>20150301</startdate><enddate>20150301</enddate><creator>Popova, E</creator><general>Springer-Verlag</general><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7QR</scope><scope>7SS</scope><scope>7TK</scope><scope>7U7</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20150301</creationdate><title>GABAergic neurotransmission and retinal ganglion cell function</title><author>Popova, E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c499t-437f7e74a16cfa113227dacbd1d3f2327589863125817b1f73eed3b282ea5de83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Animal Physiology</topic><topic>Animals</topic><topic>antagonists</topic><topic>Biomedical and Life Sciences</topic><topic>brain</topic><topic>GABA Antagonists - pharmacology</topic><topic>GABAergic Neurons - drug effects</topic><topic>GABAergic Neurons - metabolism</topic><topic>gamma-aminobutyric acid</topic><topic>gamma-Aminobutyric Acid - metabolism</topic><topic>ganglia</topic><topic>Humans</topic><topic>Life Sciences</topic><topic>Light</topic><topic>Light Signal Transduction</topic><topic>mammals</topic><topic>neurons</topic><topic>Neurosciences</topic><topic>neurotransmitters</topic><topic>Photic Stimulation</topic><topic>physiology</topic><topic>receptors</topic><topic>Receptors, GABA - metabolism</topic><topic>retina</topic><topic>Retinal Ganglion Cells - drug effects</topic><topic>Retinal Ganglion Cells - metabolism</topic><topic>Review</topic><topic>Synaptic Potentials</topic><topic>Synaptic Transmission - drug effects</topic><topic>Zoology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Popova, E</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - 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There are ~20 different types of ganglion cells, each encoding a specific aspect of the visual scene as spatial and temporal contrast, orientation, direction of movement, presence of looming stimuli; etc. Ganglion cell functioning depends on the intrinsic properties of ganglion cell’s membrane as well as on the excitatory and inhibitory inputs that these cells receive from other retinal neurons. GABA is one of the most abundant inhibitory neurotransmitters in the retina. How it modulates the activity of different types of ganglion cells and what is its significance in extracting the basic features from visual scene are questions with fundamental importance in visual neuroscience. The present review summarizes current data concerning the types of membrane receptors that mediate GABA action in proximal retina; the effects of GABA and its antagonists on the ganglion cell light-evoked postsynaptic potentials and spike discharges; the action of GABAergic agents on centre-surround organization of the receptive fields and feature related ganglion cell activity. Special emphasis is put on the GABA action regarding the ON–OFF and sustained–transient ganglion cell dichotomy in both nonmammalian and mammalian retina.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>25656810</pmid><doi>10.1007/s00359-015-0981-z</doi><tpages>23</tpages></addata></record> |
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| subjects | Animal Physiology Animals antagonists Biomedical and Life Sciences brain GABA Antagonists - pharmacology GABAergic Neurons - drug effects GABAergic Neurons - metabolism gamma-aminobutyric acid gamma-Aminobutyric Acid - metabolism ganglia Humans Life Sciences Light Light Signal Transduction mammals neurons Neurosciences neurotransmitters Photic Stimulation physiology receptors Receptors, GABA - metabolism retina Retinal Ganglion Cells - drug effects Retinal Ganglion Cells - metabolism Review Synaptic Potentials Synaptic Transmission - drug effects Zoology |
| title | GABAergic neurotransmission and retinal ganglion cell function |
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