Increase in wild-type p53 stability and transactivational activity by the chemopreventive agent apigenin in keratinocytes

Apigenin, a naturally occurring, non-mutagenic flavonoid, has been shown to inhibit UV-induced skin tumorigenesis in mice when topically applied. In this report we have used the mouse keratinocyte 308 cell line, which contains a wild-type p53 gene, to study the effect of apigenin treatment on p53 pr...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Carcinogenesis (New York) 2000-04, Vol.21 (4), p.633-639
Hauptverfasser:	McVean, Maralee, Xiao, Hengyi, Isobe, Ken-ichi, Pelling, Jill C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anticarcinogenic Agents - pharmacology Apigenin Biological and medical sciences Carcinogenesis, carcinogens and anticarcinogens casein kinase II Cdk Cell Cycle - drug effects Cell Line CKII cyclin-dependent kinase dimethyl sulfoxide DMSO DNA - metabolism Flavonoids - pharmacology Foods and miscellaneous JNK1 jun-amino-terminal kinase Keratinocytes - drug effects Keratinocytes - metabolism Medical sciences Mice Mice, Inbred BALB C p21 protein Phosphorylation PKC protein kinase C RNA, Messenger - analysis TLB Trans-Activators - physiology Tris lysis buffer Tumor Suppressor Protein p53 - chemistry Tumor Suppressor Protein p53 - physiology Tumors waf1 gene
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!