Nephrotoxicity of hexachloro-1:3-butadiene in the male Hanover Wistar rat; correlation of minimal histopathological changes with biomarkers of renal injury

ABSTRACT Hexachloro‐1:3‐butadiene (HCBD) causes damage specifically to the renal proximal tubule in rats. In the present study, injury to the nephron of male Hanover Wistar rats was characterized at 24 h following dosing with HCBD in the range 5–90 mg kg−1 to determine the most sensitive biomarkers...

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Veröffentlicht in:	Journal of applied toxicology 2012-06, Vol.32 (6), p.417-428
Hauptverfasser:	Swain, Aubrey, Turton, John, Scudamore, Cheryl, Maguire, David, Pereira, Ines, Freitas, Sofia, Smyth, Rosemary, Munday, Michael, Stamp, Clare, Gandhi, Mitul, Sondh, Surjit, Ashall, Holly, Francis, Ian, Woodfine, Jennifer, Bowles, John, York, Malcolm
Format:	Artikel
Sprache:	eng
Schlagworte:	Albumins Albuminuria - blood Albuminuria - diagnosis Albuminuria - urine Animals Apoptosis - drug effects Biological and medical sciences Biomarkers Biomarkers - blood Biomarkers - urine Butadienes - toxicity Cell Adhesion Molecules - blood Cell Adhesion Molecules - genetics Cell Adhesion Molecules - urine Damage Dose-Response Relationship, Drug Fungicides, Industrial - toxicity Gene expression Gene Expression - drug effects Glutathione Transferase - blood Glutathione Transferase - urine hexachloro-1:3-butadiene Injections, Intraperitoneal Injuries Isoenzymes - blood Isoenzymes - urine Kidney - drug effects Kidney - metabolism Kidney - pathology Kidney Diseases - chemically induced Kidney Diseases - metabolism Kidney Diseases - pathology Kidney Tubules, Proximal - drug effects Kidney Tubules, Proximal - ultrastructure Kidneys Liver - drug effects Liver - pathology Male Males Medical sciences Organ Size - drug effects Oxidative Stress - drug effects Oxidative Stress - genetics rat Rats Rats, Wistar Real-Time Polymerase Chain Reaction renal injury toxicity toxicogenomics Toxicology urinary biomarkers
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