Neuroprotective effect of water extract of Panax ginseng on corticosterone-induced apoptosis in PC12 cells and its underlying molecule mechanisms

The root of Panax ginseng C.A. Meyer (Family Araliaceae) is an important medicinal plant which has been employed as a panacea for more than 2,000 years in China. It has the actions of invigorating primordial qi, recovering pulse and desertion, engendering liquid, and calming spirit. The water extrac...

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Veröffentlicht in:	Journal of ethnopharmacology 2015-01, Vol.159, p.102-112
Hauptverfasser:	Jiang, Yumao, Li, Zongyang, Liu, Yamin, Liu, Xinmin, Chang, Qi, Liao, Yonghong, Pan, Ruile
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - drug effects Apoptosis Regulatory Proteins - metabolism Araliaceae Calcium - metabolism Caspase 3 - metabolism Caspase 9 - metabolism Corticosterone - pharmacology Cytochromes c - metabolism Endoplasmic reticulum stress Endoplasmic Reticulum Stress - drug effects Glucocorticoid receptor Heat shock protein 90 Histone Deacetylase 6 Histone Deacetylases - metabolism Histone deactylase 6 HSP90 Heat-Shock Proteins - metabolism L-Lactate Dehydrogenase - metabolism Membrane Potential, Mitochondrial - drug effects Mitochondria stress Mitochondrial Membrane Transport Proteins - metabolism Neuroprotective Agents - pharmacology Panax Panax ginseng Panax ginseng C.A. Meyer PC12 Cells Plant Extracts - pharmacology Plant Roots Rats Reactive Oxygen Species - metabolism Receptors, Glucocorticoid - metabolism Solvents - chemistry Water - chemistry
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